HitPredict

Interactor 1: ATF3 (P18847)
Cyclic AMP-dependent transcription factor ATF-3 (cAMP-dependent transcription factor ATF-3) (Activating transcription factor 3)
Gene: ATF3

Interactor 2: HDAC6 (Q9UBN7)
Histone deacetylase 6 (HD6) (EC 3.5.1.98) (Protein deacetylase HDAC6) (EC 3.5.1.-) (Tubulin-lysine deacetylase HDAC6) (EC 3.5.1.-)
Gene: HDAC6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.573

Property	Details
Experiments	22989952
Identification Methods	two hybrid, affinity chromatography technology, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 181 Hs			1 1215
+	Hs
		579204 ATF3_HUMAN (1-181): 6.23e-42: 140: 100.00		HDAC1_HUMAN (478-896): 4.05e-166: 503: 20.09
+	Mm
		936396 ATF3_MOUSE (1-181): 6.94e-41: 137: 95.03		HDAC2_MOUSE (78-489): 8.71e-157: 479: 21.02
+	Hs
		579186 ATF3_HUMAN (1-181): 6.23e-42: 140: 100.00		HDAC4_HUMAN (405-873): 1.97e-147: 474: 36.51
+	Hs
		579223 ATF3_HUMAN (1-181): 6.23e-42: 140: 100.00		HDA10_HUMAN (85-449): 8.19e-152: 473: 53.53
+	Mm
		140216 JUNB_MOUSE (10-155): 8.33e-28: 108: 18.37		HDAC1_MOUSE (80-482): 2.38e-166: 504: 20.94
+	Hs
		579236 ATF3_HUMAN (1-181): 6.23e-42: 140: 100.00		HDAC5_HUMAN (33-471): 3.29e-145: 469: 32.48
+	Hs
		401956 JUN_HUMAN (10-155): 1.25e-23: 96.9: 19.73		HDAC1_HUMAN (478-896): 4.05e-166: 503: 20.09
+	Dm
		599218 FOSLA_DROME (4-163): 3.4e-27: 108: 23.13		HDAC1_DROME (79-483): 6.2e-159: 486: 19.01
+	Hs
		177189 ATF3_HUMAN (1-181): 6.23e-42: 140: 100.00		HDAC3_HUMAN (479-890): 6.6e-146: 448: 18.29
+	Mm
		450547 JUNB_MOUSE (10-155): 8.33e-28: 108: 18.37		HDAC2_MOUSE (78-489): 8.71e-157: 479: 21.02
+	Sp
		857023 ATF1_SCHPO (7-171): 3.47e-26: 105: 20.48		CLR3_SCHPO (57-496): 1.51e-154: 480: 35.40
+	Hs
		345504 FOS_HUMAN (14-158): 2.36e-25: 102: 26.25		HDAC2_HUMAN (78-489): 1.04e-157: 481: 21.02
+	Hs
		402302 JUN_HUMAN (10-155): 1.25e-23: 96.9: 19.73		HDAC2_HUMAN (78-489): 1.04e-157: 481: 21.02
+	Hs
		547761 ATF2_HUMAN (17-162): 6.51e-25: 101: 21.92		HDAC4_HUMAN (405-873): 1.97e-147: 474: 36.51
+	Sp
		223487 ATF1_SCHPO (7-171): 3.47e-26: 105: 20.48		CLR6_SCHPO (478-878): 7.19e-149: 455: 20.48
+	Mm
		1141349 ATF3_MOUSE (1-181): 6.94e-41: 137: 95.03		Q9JM08_MOUSE (477-890): 2.06e-134: 418: 19.31
+	Ce
		105173 FOS1_CAEEL (11-160): 5.09e-22: 93.8: 18.00		HDA1_CAEEL (478-901): 1.62e-150: 461: 18.82
+	Hs
		177168 JUN_HUMAN (10-155): 1.25e-23: 96.9: 19.73		HDAC3_HUMAN (479-890): 6.6e-146: 448: 18.29
+	Hs
		402607 JUN_HUMAN (10-155): 1.25e-23: 96.9: 19.73		HDAC9_HUMAN (7-432): 5.62e-136: 441: 33.19
+	Mm
		404159 JUN_MOUSE (10-155): 1.94e-23: 96.5: 19.46		Q9JM08_MOUSE (477-890): 2.06e-134: 418: 19.31