HitPredict

Interactor 1: K2C4 (P19013)
Keratin, type II cytoskeletal 4 (Cytokeratin-4) (CK-4) (Keratin-4) (K4) (Type-II keratin Kb4)
Gene: KRT4

Interactor 2: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	21145461
Identification Methods	tandem affinity purification
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 520 Hs			1 768
+	Hs
		380606 K2C1_HUMAN (102-468): 1.76e-159: 469: 69.21		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		409064 K2C8_HUMAN (109-484): 5.4e-161: 467: 62.50		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		729080 K22E_HUMAN (109-490): 3.71e-151: 448: 65.71		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1042014 K2C78_HUMAN (71-481): 5.46e-140: 415: 60.38		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1042632 KRT84_HUMAN (1-518): 2.44e-101: 318: 46.72		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		380607 K2C1_HUMAN (102-468): 1.76e-159: 469: 69.21		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		380608 K2C1_HUMAN (102-468): 1.76e-159: 469: 69.21		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		729081 K22E_HUMAN (109-490): 3.71e-151: 448: 65.71		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		729082 K22E_HUMAN (109-490): 3.71e-151: 448: 65.71		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		380604 K2C1_HUMAN (102-468): 1.76e-159: 469: 69.21		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		729078 K22E_HUMAN (109-490): 3.71e-151: 448: 65.71		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		380605 K2C1_HUMAN (102-468): 1.76e-159: 469: 69.21		CUL2_HUMAN (30-768): 0: 672: 26.17
+	Hs
		729079 K22E_HUMAN (109-490): 3.71e-151: 448: 65.71		CUL2_HUMAN (30-768): 0: 672: 26.17
+	Hs
		1041394 K2C78_HUMAN (71-481): 5.46e-140: 415: 60.38		CUL2_HUMAN (30-768): 0: 672: 26.17
+	Hs
		1192454 K2C1B_HUMAN (47-468): 4.52e-166: 484: 61.86		CUL5_HUMAN (25-768): 0: 597: 23.77
+	Hs
		517775 K2C3_HUMAN (109-492): 1.48e-160: 471: 72.24		CUL5_HUMAN (25-768): 0: 597: 23.77
+	Hs
		380662 K2C1_HUMAN (102-468): 1.76e-159: 469: 69.21		CUL5_HUMAN (25-768): 0: 597: 23.77
+	Hs
		729149 K22E_HUMAN (109-490): 3.71e-151: 448: 65.71		CUL5_HUMAN (25-768): 0: 597: 23.77
+	Hs
		318802 K2C75_HUMAN (2-464): 3.36e-94: 298: 64.29		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		318803 K2C75_HUMAN (2-464): 3.36e-94: 298: 64.29		CUL2_HUMAN (30-768): 0: 672: 26.17