HitPredict

Interactor 1: CADH2 (P19022)
Cadherin-2 (CDw325) (Neural cadherin) (N-cadherin) (CD antigen CD325)
Gene: CDH2

Interactor 2: PTN22 (Q9Y2R2)
Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP) (PEST-domain phosphatase) (PEP)
Gene: PTPN22

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	19167335
Identification Methods	phosphatase assay
Interaction Type	dephosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 906 Hs			1 807
+	Hs
		580226 CADH2_HUMAN (1-906): 0: 998: 100.00		PTN12_HUMAN (1-696): 0: 723: 36.81
+	Hs
		580204 CADH2_HUMAN (1-906): 0: 998: 100.00		PTN6_HUMAN (2-344): 6.3e-137: 420: 32.30
+	Hs
		580200 CADH2_HUMAN (1-906): 0: 998: 100.00		PTPRB_HUMAN (18-314): 2.09e-117: 393: 31.19
+	Hs
		576981 CADH2_HUMAN (1-906): 0: 998: 100.00		PTPRA_HUMAN (29-290): 2.44e-104: 341: 36.33
+	Rn
		1145482 CADH2_RAT (1-906): 0: 989: 96.25		PTPRF_RAT (6-292): 2.94e-102: 349: 36.43
+	Gg
		140363 CADH2_CHICK (1-906): 0: 970: 85.20		PTN1_CHICK (22-288): 7.59e-118: 365: 34.88
+	Hs
		580235 CADH2_HUMAN (1-906): 0: 998: 100.00		PTPRK_HUMAN (20-292): 9.08e-61: 225: 30.96
+	Rn
		94056 CADH2_RAT (1-906): 0: 989: 96.25		F1LPJ1_RAT (20-293): 1.61e-61: 228: 29.08
+	Hs
		580201 CADH2_HUMAN (1-906): 0: 998: 100.00		PTPRG_HUMAN (30-294): 3.35e-51: 196: 25.54
+	Hs
		580229 CADH2_HUMAN (1-906): 0: 998: 100.00		PTPRJ_HUMAN (15-295): 2.81e-48: 187: 38.10
+	Hs
		580238 CADH2_HUMAN (1-906): 0: 998: 100.00		PTPRO_HUMAN (45-299): 3.56e-43: 171: 38.22
+	Hs
		521727 CADH1_HUMAN (26-906): 0: 764: 45.71		PTPRD_HUMAN (13-292): 2.14e-106: 361: 36.36
+	Hs
		521907 CADH1_HUMAN (26-906): 0: 764: 45.71		PTPRS_HUMAN (13-292): 1.12e-105: 359: 35.66
+	Hs
		489891 CADH1_HUMAN (26-906): 0: 764: 45.71		PTPRF_HUMAN (6-292): 1.61e-101: 347: 36.77
+	Hs
		441173 CADH2_HUMAN (1-906): 0: 998: 100.00		PTPRC_HUMAN (61-462): 5.14e-11: 68.6: 9.24
+	Hs
		616974 DSC3_HUMAN (5-899): 0: 700: 30.32		PTPRD_HUMAN (13-292): 2.14e-106: 361: 36.36
+	Hs
		521743 CADH1_HUMAN (26-906): 0: 764: 45.71		PTPRM_HUMAN (20-293): 3.03e-61: 227: 28.72
+	Mm
		454946 CADH1_MOUSE (2-906): 0: 743: 45.13		PTPRM_MOUSE (20-293): 1.23e-61: 228: 29.08
+	Hs
		521728 CADH1_HUMAN (26-906): 0: 764: 45.71		PTPRG_HUMAN (30-294): 3.35e-51: 196: 25.54
+	Hs
		521898 CADH1_HUMAN (26-906): 0: 764: 45.71		PTPRJ_HUMAN (15-295): 2.81e-48: 187: 38.10