HitPredict

Interactor 1: CDC42 (P19073)
Cell division control protein 42 (EC 3.6.5.2) (Suppressor of RHO3 protein 2)
Gene: CDC42

Interactor 2: SEC3 (P33332)
Exocyst complex component SEC3 (Protein PSL1)
Gene: SEC3

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	11595741, 18195105, 20823269
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Ras~Sec3-PIP2_bind
Common GO terms	GO:0000131 - incipient cellular bud site GO:0005886 - plasma membrane GO:0005934 - cellular bud tip GO:0005935 - cellular bud neck GO:0043332 - mating projection tip
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Sc			1 1336
+	Hs
		564633 RHOQ_HUMAN (4-179): 5.4e-85: 251: 66.48		MY18A_HUMAN (102-736): 1.57e-29: 130: 10.56
+	Hs
		925488 RAC1_HUMAN (1-191): 4.15e-83: 245: 68.75		MY18A_HUMAN (102-736): 1.57e-29: 130: 10.56
+	Hs
		894274 CDC42_HUMAN (1-191): 1.04e-80: 239: 80.11		MY18A_HUMAN (102-736): 1.57e-29: 130: 10.56
+	Hs
		254445 RHOQ_HUMAN (4-179): 5.4e-85: 251: 66.48		ROCK2_HUMAN (60-738): 1.7e-25: 117: 10.62
+	Hs
		254468 RAC1_HUMAN (1-191): 4.15e-83: 245: 68.75		ROCK2_HUMAN (60-738): 1.7e-25: 117: 10.62
+	Hs
		254472 RHOG_HUMAN (1-191): 1.71e-81: 241: 58.64		ROCK2_HUMAN (60-738): 1.7e-25: 117: 10.62
+	Hs
		564758 RHOQ_HUMAN (4-179): 5.4e-85: 251: 66.48		MRCKB_HUMAN (521-890): 5.67e-19: 96: 9.44
+	Hs
		564564 RHOQ_HUMAN (4-179): 5.4e-85: 251: 66.48		MRCKA_HUMAN (108-548): 6.4e-19: 95.6: 12.03
+	Mm
		823530 RAC1_MOUSE (1-191): 4.15e-83: 245: 68.75		CTRO_MOUSE (85-616): 1.26e-20: 101: 10.52
+	Hs
		876341 CDC42_HUMAN (1-191): 1.04e-80: 239: 80.11		AFAD_HUMAN (249-448): 1.84e-22: 107: 26.40
+	Hs
		925766 RAC1_HUMAN (1-191): 4.15e-83: 245: 68.75		MRCKB_HUMAN (521-890): 5.67e-19: 96: 9.44
+	Hs
		925344 RAC1_HUMAN (1-191): 4.15e-83: 245: 68.75		MRCKA_HUMAN (108-548): 6.4e-19: 95.6: 12.03
+	Mm
		823529 CDC42_MOUSE (1-191): 1.04e-80: 239: 80.11		CTRO_MOUSE (85-616): 1.26e-20: 101: 10.52
+	Hs
		951494 RHOG_HUMAN (1-191): 1.71e-81: 241: 58.64		MRCKB_HUMAN (521-890): 5.67e-19: 96: 9.44
+	Hs
		951069 RHOG_HUMAN (1-191): 1.71e-81: 241: 58.64		MRCKA_HUMAN (108-548): 6.4e-19: 95.6: 12.03
+	Hs
		551652 CDC42_HUMAN (1-191): 1.04e-80: 239: 80.11		DESP_HUMAN (265-829): 4.8e-19: 96.5: 9.43
+	Hs
		894628 CDC42_HUMAN (1-191): 1.04e-80: 239: 80.11		MRCKB_HUMAN (521-890): 5.67e-19: 96: 9.44
+	Hs
		894116 CDC42_HUMAN (1-191): 1.04e-80: 239: 80.11		MRCKA_HUMAN (108-548): 6.4e-19: 95.6: 12.03
+	Hs
		894047 CDC42_HUMAN (1-191): 1.04e-80: 239: 80.11		ITSN1_HUMAN (114-451): 8.93e-18: 92.1: 10.76
+	Hs
		148653 RAC1_HUMAN (1-191): 4.15e-83: 245: 68.75		CTRO_HUMAN (70-510): 3.56e-11: 70.2: 11.84