Protein: IF6
Eukaryotic translation initiation factor 6 (eIF-6)

Gene: IF6, TIF6
Organism: Saccharomyces cerevisiae S288C
Interactions: 191
UniProt ID: Q12522

Gene Ontology (top 5):
GO:0000054 - ribosomal subunit export from nucleus
GO:0000460 - maturation of 5.8S rRNA
GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000470 - maturation of LSU-rRNA

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1039669

NOG1
Nucleolar GTP-binding protein 1

7

2

Small-scale

0.960

High

1060838

RLP24
Ribosome biogenesis protein RLP24

5

3

Small-scale

0.902

High

513434

RL23B
Large ribosomal subunit protein uL14B

4

0

Small-scale

0.828

High

1085029

IF6
Eukaryotic translation initiation factor 6

3

0

Small-scale

0.791

High

570195

RL3
Large ribosomal subunit protein uL3

2

2

Small-scale

0.789

High

917710

LSG1
Large subunit GTPase 1

13

5

Small-scale

0.761

High

1044243

ARX1
Probable metalloprotease ARX1

15

1

Small-scale

0.760

High

804694

SSF1
Ribosome biogenesis protein SSF1

11

1

Small-scale

0.754

High

677265

SPB1
27S pre-rRNA

2

1

Small-scale

0.754

High

923232

NOG2
Nucleolar GTP-binding protein 2

10

5

Small-scale

0.752

High

750178

MRT4
Ribosome assembly factor MRT4

7

2

Small-scale

0.743

High

782504

RPF2
Ribosome biogenesis protein RPF2

7

1

Small-scale

0.742

High

1046546

PUF6
Pumilio homology domain family member 6

6

1

Small-scale

0.736

High

917588

NSA1
Ribosome biogenesis protein NSA1

6

1

Small-scale

0.733

High

806188

NMD3
60S ribosomal export protein NMD3

6

1

Small-scale

0.727

High

919059

PESC
Pescadillo homolog

13

0

Small-scale

0.727

High

806682

RIX1
Pre-rRNA-processing protein RIX1

9

0

Small-scale

0.721

High

1047310

ERB1
Ribosome biogenesis protein ERB1

5

1

Small-scale

0.718

High

805117

RPF1
Ribosome production factor 1

5

1

Small-scale

0.714

High

1043322

HAS1
ATP-dependent RNA helicase HAS1

5

5

Small-scale

0.714

High

1084866

DBP10
ATP-dependent RNA helicase DBP10

5

2

Small-scale

0.714

High

601159

RL8A
Large ribosomal subunit protein eL8A

5

2

Small-scale

0.702

High

818301

NSA2
Ribosome biogenesis protein NSA2

6

0

Small-scale

0.699

High

850046

LOC1
60S ribosomal subunit assembly/export protein LOC1

6

0

Small-scale

0.699

High

1062799

BRX1
Ribosome biogenesis protein BRX1

4

8

Small-scale

0.696

High

746698

DRS1
ATP-dependent RNA helicase DRS1

4

3

Small-scale

0.694

High

827651

RLP7
Ribosome biogenesis protein RLP7

4

3

Small-scale

0.694

High

924876

NOP15
Ribosome biogenesis protein 15

4

1

High-throughput

0.694

High

1060757

NOC3
Nucleolar complex-associated protein 3

4

1

Small-scale

0.694

High

1084132

YTM1
Ribosome biogenesis protein YTM1

4

2

Small-scale

0.694

High

830222

NOP2
25S rRNA

4

2

Small-scale

0.691

High

633210

MAK11
Protein MAK11

4

1

Small-scale

0.686

High

816938

NUG1
Nuclear GTP-binding protein NUG1

4

5

Small-scale

0.686

High

919572

SDA1
Protein SDA1

3

1

High-throughput

0.667

High

924266

IPI3
Pre-rRNA-processing protein IPI3

3

2

High-throughput

0.667

High

1061412

BUD20
Bud site selection protein 20

4

0

Small-scale

0.664

High

1036140

PVH1
Tyrosine-protein phosphatase YVH1

3

1

Small-scale

0.658

High

814423

NOC2
Nucleolar complex protein 2

4

0

Small-scale

0.657

High

803974

CIC1
Proteasome-interacting protein CIC1

3

1

Small-scale

0.656

High

645019

RPA2
DNA-directed RNA polymerase I subunit RPA135

3

1

High-throughput

0.650

High

673601

NLE1
Ribosome assembly protein 4

4

0

Small-scale

0.648

High

682435

SPB4
ATP-dependent rRNA helicase SPB4

3

3

High-throughput

0.640

High

763145

RRP1
Ribosomal RNA-processing protein 1

3

2

Small-scale

0.640

High

684892

RL5
Large ribosomal subunit protein uL18

3

0

Small-scale

0.638

High

816816

NOP16
Nucleolar protein 16

3

0

Small-scale

0.628

High

546889

SSB1
Ribosome-associated molecular chaperone SSB1

3

1

Small-scale

0.624

High

409806

RL24A
Large ribosomal subunit protein eL24A

1

3

Small-scale

0.618

High

712703

RL8B
Large ribosomal subunit protein eL8B

2

2

Small-scale

0.611

High

585419

FBRL
rRNA 2'-O-methyltransferase fibrillarin

2

0

High-throughput

0.602

High

752000

LHP1
La protein homolog

2

0

High-throughput

0.602

High

438510

EIF3B
Eukaryotic translation initiation factor 3 subunit B

2

1

High-throughput

0.601

High

738448

EIF3C
Eukaryotic translation initiation factor 3 subunit C

2

1

High-throughput

0.601

High

790525

CCL1
Cyclin CCL1

2

1

High-throughput

0.601

High

796648

EIF3A
Eukaryotic translation initiation factor 3 subunit A

2

1

High-throughput

0.601

High

434466

RL15A
Large ribosomal subunit protein eL15A

2

0

High-throughput

0.585

High

689170

RL16A
Large ribosomal subunit protein uL13A

2

0

High-throughput

0.585

High

798519

REI1
Cytoplasmic 60S subunit biogenesis factor REI1

2

2

Small-scale

0.584

High

1056596

REH1
Cytoplasmic 60S subunit biogenesis factor REH1

2

2

Small-scale

0.584

High

1084247

NOP53
Ribosome biogenesis protein NOP53

2

1

High-throughput

0.584

High

393583

HSP82
ATP-dependent molecular chaperone HSP82

2

2

Small-scale

0.571

High

395042

EF1A
Elongation factor 1-alpha

2

1

Small-scale

0.571

High

525668

HSP71
Heat shock protein SSA1

2

1

Small-scale

0.571

High

528117

HSP72
Heat shock protein SSA2

2

1

Small-scale

0.571

High

820216

SSB2
Ribosome-associated molecular chaperone SSB2

2

1

Small-scale

0.571

High

1046333

VMS1
tRNA endonuclease VMS1

2

3

Small-scale

0.571

High

815291

IF4F1
Eukaryotic initiation factor 4F subunit p150

2

0

Small-scale

0.559

High

826966

DSN1
Kinetochore-associated protein DSN1

2

0

High-throughput

0.559

High

864203

ALB1
Ribosome biogenesis protein ALB1

2

0

Small-scale

0.559

High

1044919

RRP17
Ribosomal RNA-processing protein 17

2

0

High-throughput

0.559

High

1055489

RRP15
Ribosomal RNA-processing protein 15

2

0

Small-scale

0.559

High

763270

SQT1
Ribosome assembly protein SQT1

1

1

High-throughput

0.541

High

511508

RL43B
Large ribosomal subunit protein eL43B

1

0

Small-scale

0.537

High

427493

RLA0
Large ribosomal subunit protein uL10

1

2

High-throughput

0.536

High

432745

RL7A
Large ribosomal subunit protein uL30A

1

3

High-throughput

0.536

High

586058

CSK21
Casein kinase II subunit alpha

1

4

High-throughput

0.536

High

743317

PP12
Serine/threonine-protein phosphatase PP1-2

1

2

High-throughput

0.536

High

885122

RL4B
Large ribosomal subunit protein uL4B

1

4

High-throughput

0.536

High

924360

NOP13
Nucleolar protein 13

1

2

High-throughput

0.536

High

1030619

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

1

High-throughput

0.536

High

1050220

RRP5
rRNA biogenesis protein RRP5

1

2

High-throughput

0.536

High

1084612

RL7B
Large ribosomal subunit protein uL30B

1

3

High-throughput

0.536

High

432935

RL9A
Large ribosomal subunit protein uL6A

1

0

High-throughput

0.513

High

448248

HAP2
Transcriptional activator HAP2

1

0

High-throughput

0.513

High

722387

XPO1
Exportin-1

1

0

High-throughput

0.513

High

820986

RL13B
Large ribosomal subunit protein eL13B

1

0

High-throughput

0.513

High

865297

LSM8
LSM2-LSM8 complex subunit LSM8

1

0

High-throughput

0.513

High

1027324

AP1M1
AP-1 complex subunit mu-1-I

1

0

High-throughput

0.513

High

1043997

TAF12
SAGA complex/transcription factor TFIID complex subunit TAF12

1

0

High-throughput

0.513

High

1050254

TAF9
SAGA complex/transcription factor TFIID complex subunit TAF9

1

0

High-throughput

0.513

High

1059622

NOP6
Nucleolar protein 6

1

0

High-throughput

0.513

High

1063915

DNLI4
DNA ligase 4

1

0

High-throughput

0.513

High

1064371

DIA2
Protein DIA2

1

0

High-throughput

0.513

High

1064504

ULS1
ATP-dependent helicase ULS1

1

0

High-throughput

0.513

High

1064754

HRK1
Serine/threonine-protein kinase HRK1

1

0

High-throughput

0.513

High

925468

HDA1
Histone deacetylase HDA1

1

3

High-throughput

0.489

High

709498

HRR25
Casein kinase I homolog HRR25

1

0

Small-scale

0.480

High

403716

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

1

Small-scale

0.479

High

504490

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.479

High

504563

RL31B
Large ribosomal subunit protein eL31B

1

1

Small-scale

0.479

High

512730

RS6A
Small ribosomal subunit protein eS6A

1

1

High-throughput

0.479

High

513799

RL2A
Large ribosomal subunit protein uL2A

1

1

High-throughput

0.479

High

534167

MAK16
Protein MAK16

1

1

High-throughput

0.479

High

580307

HSC82
ATP-dependent molecular chaperone HSC82

1

2

Small-scale

0.479

High

626942

HSP60
Heat shock protein 60, mitochondrial

1

2

Small-scale

0.479

High

742763

HSP7F
Heat shock protein homolog SSE1

1

3

Small-scale

0.479

High

751524

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

1

High-throughput

0.479

High

780352

EBP2
rRNA-processing protein EBP2

1

2

High-throughput

0.479

High

792327

GBLP
Small ribosomal subunit protein RACK1

1

2

High-throughput

0.479

High

795617

ATG8
Autophagy-related protein 8

1

1

High-throughput

0.479

High

807184

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

3

High-throughput

0.479

High

817302

ARB1
ABC transporter ATP-binding protein ARB1

1

1

Small-scale

0.479

High

823068

ATAD2
ATPase histone chaperone YTA7

1

1

High-throughput

0.479

High

963817

H3
Histone H3

1

1

High-throughput

0.479

High

1042284

TOM1
E3 ubiquitin-protein ligase TOM1

1

2

High-throughput

0.479

High

1044524

RUVB1
RuvB-like protein 1

1

1

High-throughput

0.479

High

1046103

DHR1
Probable ATP-dependent RNA helicase DHR1

1

2

High-throughput

0.479

High

1046136

RRB1
Ribosome assembly protein RRB1

1

2

High-throughput

0.479

High

1054273

FKBP4
FK506-binding protein 4

1

3

High-throughput

0.479

High

1054379

JIP5
WD repeat-containing protein JIP5

1

2

High-throughput

0.479

High

1054419

DBP9
ATP-dependent RNA helicase DBP9

1

2

High-throughput

0.479

High

1055535

NOC4
Nucleolar complex protein 4

1

3

High-throughput

0.479

High

1064864

RRS1
Regulator of ribosome biosynthesis

1

1

High-throughput

0.479

High

1084542

MAK21
Ribosome biogenesis protein MAK21

1

3

Small-scale

0.479

High

1085030

SMC6
Structural maintenance of chromosomes protein 6

1

1

High-throughput

0.479

High

150027

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.458

High

383965

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.458

High

410412

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.458

High

433918

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.458

High

435457

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

436246

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

436557

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

0

High-throughput

0.458

High

442188

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.458

High

455334

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.458

High

503316

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.458

High

513297

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.458

High

514081

RL18B
Large ribosomal subunit protein eL18B

1

0

High-throughput

0.458

High

514904

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

515191

RL19B
Large ribosomal subunit protein eL19

1

0

High-throughput

0.458

High

671283

SIS1
Protein SIS1

1

0

High-throughput

0.458

High

674911

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

677636

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.458

High

689738

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.458

High

708634

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

710058

BMH1
Protein BMH1

1

0

High-throughput

0.458

High

727433

HS104
Heat shock protein 104

1

0

High-throughput

0.458

High

735241

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

745114

AFG2
ATPase family gene 2 protein

1

0

High-throughput

0.458

High

747658

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.458

High

753667

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.458

High

778606

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

780729

RRP14
Ribosomal RNA-processing protein 14

1

0

High-throughput

0.458

High

795861

YBC8
UPF0642 protein YBL028C

1

0

High-throughput

0.458

High

798362

ENP1
Essential nuclear protein 1

1

0

High-throughput

0.458

High

802462

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

805026

IPI1
Pre-rRNA-processing protein IPI1

1

0

High-throughput

0.458

High

812797

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.458

High

813728

ECM1
Shuttling pre-60S factor ECM1

1

0

High-throughput

0.458

High

826122

ULP2
Ubiquitin-like-specific protease 2

1

0

High-throughput

0.458

High

835920

RL10
Large ribosomal subunit protein uL16

1

0

Small-scale

0.458

High

844676

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.458

High

874608

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

918035

VIR
Protein virilizer

1

0

High-throughput

0.458

High

923900

GIS2
Zinc finger protein GIS2

1

0

High-throughput

0.458

High

925168

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

932263

ORC1
Origin recognition complex subunit 1

1

0

High-throughput

0.458

High

1033647

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

1054026

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

1059446

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.458

High

1064308

SGO1
Shugoshin

1

0

High-throughput

0.458

High

1064685

TMA16
Translation machinery-associated protein 16

1

0

High-throughput

0.458

High

1064842

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.458

High

1065576

NIP7
60S ribosome subunit biogenesis protein NIP7

1

0

High-throughput

0.458

High

1084094

YO289
Uncharacterized protein YOR289W

1

0

Small-scale

0.458

High

1084121

MDN1
Midasin

1

0

High-throughput

0.458

High

1084998

NOP58
Nucleolar protein 58

1

0

High-throughput

0.458

High

531941

RL4A
Large ribosomal subunit protein uL4A

1

4

High-throughput

0.445

High

794024

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

3

High-throughput

0.445

High

924083

JJJ1
J protein JJJ1

1

2

High-throughput

0.445

High

801802

KPR3
Ribose-phosphate pyrophosphokinase 3

1

0

High-throughput

0.426

High

918054

CGR1
rRNA-processing protein CGR1

1

0

High-throughput

0.426

High

923164

BRE5
UBP3-associated protein BRE5

1

0

High-throughput

0.426

High

1036367

ADA2
SAGA complex subunit ADA2

1

0

High-throughput

0.426

High

444387

HIS7
Imidazoleglycerol-phosphate dehydratase

1

0

High-throughput

0.279

Low

1085022

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

1

0

High-throughput

0.279

Low

758360

MTC2
Maintenance of telomere capping protein 2

1

0

High-throughput

0.261

Low

739836

SPT16
FACT complex subunit SPT16

1

0

High-throughput

0.249

Low

795293

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

925410

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.249

Low

1084389

ATG9
Autophagy-related protein 9

1

0

High-throughput

0.249

Low

1085031

YO192
Uncharacterized protein YOR192C-C

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025