HitPredict

Interactor 1: CDC42 (P19073)
Cell division control protein 42 (EC 3.6.5.2) (Suppressor of RHO3 protein 2)
Gene: CDC42

Interactor 2: BOB1 (P38041)
Protein BOB1 (BEM1-binding protein) (Growth inhibitory protein 7)
Gene: BOI1

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.800

Property	Details
Experiments	8666672, 28751498
Identification Methods	two hybrid, protein complementation assay, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PH~Ras
Common GO terms	GO:0005886 - plasma membrane GO:0005935 - cellular bud neck GO:0007015 - actin filament organization GO:0007118 - budding cell apical bud growth GO:0043332 - mating projection tip
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 191 Sc			1 980
+	Sc
		580319 CDC42_YEAST (1-191): 2.07e-79: 236: 100.00		BOI2_YEAST (4-940): 5.86e-88: 306: 35.07
+	Sp
		251748 CDC42_SCHPO (1-191): 1.65e-80: 239: 84.90		POB1_SCHPO (19-936): 2.21e-41: 166: 20.99
+	Hs
		564587 RHOQ_HUMAN (4-179): 5.4e-85: 251: 66.48		MICA3_HUMAN (36-685): 3.96e-24: 112: 10.35
+	Hs
		925387 RAC1_HUMAN (1-191): 4.15e-83: 245: 68.75		MICA3_HUMAN (36-685): 3.96e-24: 112: 10.35
+	Hs
		1186089 RHOJ_HUMAN (2-189): 4.76e-79: 236: 59.04		MICA3_HUMAN (36-685): 3.96e-24: 112: 10.35
+	Ce
		136793 RAC1_CAEEL (1-191): 3.61e-84: 248: 66.49		UNC89_CAEEL (71-781): 3.7e-20: 99.3: 8.85
+	Hs
		892450 RAC3_HUMAN (1-177): 4.26e-77: 230: 71.19		MICA3_HUMAN (36-685): 3.96e-24: 112: 10.35
+	Ce
		104464 G5EBV3_CAEEL (2-191): 1.91e-80: 239: 57.90		UNC89_CAEEL (71-781): 3.7e-20: 99.3: 8.85
+	Hs
		297823 RAC1_HUMAN (1-191): 4.15e-83: 245: 68.75		K0754_HUMAN (458-935): 8.81e-18: 91.6: 10.04
+	Ce
		136794 CDC42_CAEEL (1-191): 8.21e-79: 235: 76.44		UNC89_CAEEL (71-781): 3.7e-20: 99.3: 8.85
+	Hs
		297827 RHOG_HUMAN (1-191): 1.71e-81: 241: 58.64		K0754_HUMAN (458-935): 8.81e-18: 91.6: 10.04
+	Hs
		297812 RAC2_HUMAN (1-191): 1.83e-79: 236: 67.71		K0754_HUMAN (458-935): 8.81e-18: 91.6: 10.04
+	Hs
		297840 RHOJ_HUMAN (2-189): 4.76e-79: 236: 59.04		K0754_HUMAN (458-935): 8.81e-18: 91.6: 10.04
+	Hs
		297820 RHOA_HUMAN (5-191): 9.78e-79: 234: 51.34		K0754_HUMAN (458-935): 8.81e-18: 91.6: 10.04
+	Ce
		136800 RHO1_CAEEL (5-191): 2.06e-74: 223: 53.48		UNC89_CAEEL (71-781): 3.7e-20: 99.3: 8.85
+	Hs
		297809 RHOC_HUMAN (5-191): 5.48e-77: 230: 51.34		K0754_HUMAN (458-935): 8.81e-18: 91.6: 10.04
+	Hs
		297819 RAC3_HUMAN (1-177): 4.26e-77: 230: 71.19		K0754_HUMAN (458-935): 8.81e-18: 91.6: 10.04