Protein: RQC2
Ribosome quality control complex subunit 2 (Translation-associated element 2)

Gene: RQC2
Organism: Saccharomyces cerevisiae S288C
Interactions: 124
UniProt ID: Q12532

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0003729 - mRNA binding
GO:0005737 - cytoplasm
GO:0010494 - cytoplasmic stress granule
GO:0022626 - cytosolic ribosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1048431

LTN1
E3 ubiquitin-protein ligase listerin

3

0

Small-scale

0.628

High

1051128

RQC1
Ribosome quality control complex subunit 1

3

0

Small-scale

0.628

High

427494

RLA0
Large ribosomal subunit protein uL10

3

0

Small-scale

0.622

High

150028

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.586

High

680195

CDC48
Cell division control protein 48

2

0

Small-scale

0.585

High

580311

HSC82
ATP-dependent molecular chaperone HSC82

2

1

High-throughput

0.584

High

751525

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

2

0

High-throughput

0.576

High

689171

RL16A
Large ribosomal subunit protein uL13A

2

0

High-throughput

0.559

High

1046334

VMS1
tRNA endonuclease VMS1

2

0

Small-scale

0.559

High

525675

HSP71
Heat shock protein SSA1

2

1

High-throughput

0.552

High

546894

SSB1
Ribosome-associated molecular chaperone SSB1

2

1

High-throughput

0.552

High

820221

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.536

High

1030620

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

1

High-throughput

0.536

High

433919

RL26A
Large ribosomal subunit protein uL24A

2

1

High-throughput

0.533

High

514387

RL12B
Large ribosomal subunit protein uL11B

1

0

High-throughput

0.517

High

722390

XPO1
Exportin-1

1

0

High-throughput

0.513

High

754458

NPL4
Nuclear protein localization protein 4

1

0

Small-scale

0.513

High

792328

GBLP
Small ribosomal subunit protein RACK1

1

0

Small-scale

0.513

High

916760

UFD1
Ubiquitin fusion degradation protein 1

1

0

Small-scale

0.513

High

814319

RV167
Reduced viability upon starvation protein 167

1

1

High-throughput

0.501

High

393586

HSP82
ATP-dependent molecular chaperone HSP82

1

1

High-throughput

0.479

High

409807

RL24A
Large ribosomal subunit protein eL24A

1

1

High-throughput

0.479

High

433320

RL17A
Large ribosomal subunit protein uL22A

1

1

High-throughput

0.479

High

509778

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

1

Small-scale

0.479

High

663737

RL24B
Large ribosomal subunit protein eL24B

1

1

High-throughput

0.479

High

684893

RL5
Large ribosomal subunit protein uL18

1

1

High-throughput

0.479

High

835921

RL10
Large ribosomal subunit protein uL16

1

1

High-throughput

0.479

High

917711

LSG1
Large subunit GTPase 1

1

1

High-throughput

0.479

High

1043323

HAS1
ATP-dependent RNA helicase HAS1

1

1

High-throughput

0.470

High

724312

ZIP1
Synaptonemal complex protein ZIP1

1

0

High-throughput

0.460

High

745925

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

0

Small-scale

0.460

High

1055784

NDE1
Nuclear distribution protein nudE homolog 1

1

0

High-throughput

0.460

High

432746

RL7A
Large ribosomal subunit protein uL30A

1

0

High-throughput

0.458

High

435458

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

436247

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

442189

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.458

High

514905

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

515349

RL35A
Large ribosomal subunit protein uL29A

1

0

High-throughput

0.458

High

569888

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.458

High

570196

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.458

High

674912

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

747659

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.458

High

778607

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

790303

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

0

High-throughput

0.458

High

802463

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

814064

IF2P
Eukaryotic translation initiation factor 5B

1

0

High-throughput

0.458

High

874609

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

919060

PESC
Pescadillo homolog

1

0

High-throughput

0.458

High

924085

JJJ1
J protein JJJ1

1

0

High-throughput

0.458

High

1033648

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

1042285

TOM1
E3 ubiquitin-protein ligase TOM1

1

0

High-throughput

0.458

High

1044612

HMO1
High mobility group protein 1

1

0

High-throughput

0.458

High

1064309

SGO1
Shugoshin

1

0

High-throughput

0.458

High

1084584

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

528123

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.445

High

758174

CASP
Protein CASP

1

1

High-throughput

0.439

High

383211

RLA4
Large ribosomal subunit protein P2B

1

1

High-throughput

0.437

High

419534

H2A1
Histone H2A.1

1

1

High-throughput

0.437

High

419922

H2A2
Histone H2A.2

1

1

High-throughput

0.437

High

427623

RLA1
Large ribosomal subunit protein P1A

1

1

High-throughput

0.437

High

427766

RLA2
Large ribosomal subunit protein P2A

1

1

High-throughput

0.437

High

432936

RL9A
Large ribosomal subunit protein uL6A

1

1

High-throughput

0.437

High

433094

RL6B
Large ribosomal subunit protein eL6B

1

1

High-throughput

0.437

High

503867

RL27A
Large ribosomal subunit protein eL27A

1

1

High-throughput

0.437

High

503962

RL27B
Large ribosomal subunit protein eL27B

1

1

High-throughput

0.437

High

515192

RL19B
Large ribosomal subunit protein eL19

1

1

High-throughput

0.437

High

528884

RLA3
Large ribosomal subunit protein P1B

1

1

High-throughput

0.437

High

601160

RL8A
Large ribosomal subunit protein eL8A

1

1

High-throughput

0.437

High

682436

SPB4
ATP-dependent rRNA helicase SPB4

1

1

High-throughput

0.437

High

712704

RL8B
Large ribosomal subunit protein eL8B

1

1

High-throughput

0.437

High

825923

RL34B
Large ribosomal subunit protein eL34B

1

1

High-throughput

0.437

High

863899

RL17B
Large ribosomal subunit protein uL22B

1

1

High-throughput

0.437

High

902688

RL9B
Large ribosomal subunit protein uL6B

1

1

High-throughput

0.437

High

918352

RL26B
Large ribosomal subunit protein uL24B

1

1

High-throughput

0.437

High

1018168

RL34A
Large ribosomal subunit protein eL34A

1

1

High-throughput

0.437

High

1036316

RL6A
Large ribosomal subunit protein eL6A

1

1

High-throughput

0.437

High

1085038

RL11B
Large ribosomal subunit protein uL5B

1

1

High-throughput

0.437

High

752929

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.426

High

863804

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.426

High

1025206

SEN1
Helicase SEN1

1

0

Small-scale

0.426

High

1084776

HSP42
Heat shock protein 42

1

0

High-throughput

0.426

High

779597

LHS1
Heat shock protein 70 homolog LHS1

1

2

High-throughput

0.407

High

410413

RL25
Large ribosomal subunit protein uL23

2

0

High-throughput

0.305

High

513800

RL2A
Large ribosomal subunit protein uL2A

2

0

High-throughput

0.305

High

830223

NOP2
25S rRNA

1

0

High-throughput

0.279

Low

916626

TAF6
SAGA complex/transcription factor TFIID complex subunit TAF6

1

0

High-throughput

0.279

Low

1042414

GCN5
Histone acetyltransferase GCN5

1

0

High-throughput

0.279

Low

1025076

NUM1
Nuclear migration protein NUM1

1

0

High-throughput

0.251

Low

154244

RL36B
Large ribosomal subunit protein eL36B

1

0

High-throughput

0.249

Low

382433

H4
Histone H4

1

0

High-throughput

0.249

Low

383966

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

434104

RL33A
Large ribosomal subunit protein eL33A

1

0

High-throughput

0.249

Low

434467

RL15A
Large ribosomal subunit protein eL15A

1

0

High-throughput

0.249

Low

434668

RL22A
Large ribosomal subunit protein eL22A

1

0

High-throughput

0.249

Low

455335

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

503317

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

504491

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.249

Low

511322

RL20B
Large ribosomal subunit protein eL20B

1

0

High-throughput

0.249

Low

511509

RL43B
Large ribosomal subunit protein eL43B

1

0

High-throughput

0.249

Low

512731

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.249

Low

513298

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

531942

RL4A
Large ribosomal subunit protein uL4A

1

0

High-throughput

0.249

Low

594657

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.249

Low

677637

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.249

Low

689739

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.249

Low

708636

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

748594

SC61A
Protein transport protein SEC61

1

0

High-throughput

0.249

Low

753668

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

781284

RL14A
Large ribosomal subunit protein eL14A

1

0

High-throughput

0.249

Low

807865

SSN2
Mediator of RNA polymerase II transcription subunit 13

1

0

Small-scale

0.249

Low

812798

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

820987

RL13B
Large ribosomal subunit protein eL13B

1

0

High-throughput

0.249

Low

844677

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.249

Low

879860

RL37A
Large ribosomal subunit protein eL37A

1

0

High-throughput

0.249

Low

1038419

RL21A
Large ribosomal subunit protein eL21A

1

0

High-throughput

0.249

Low

1044866

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low

1046104

DHR1
Probable ATP-dependent RNA helicase DHR1

1

0

High-throughput

0.249

Low

1054027

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

1064843

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.249

Low

793022

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.238

Low

811444

CAJ1
Protein CAJ1

1

0

High-throughput

0.232

Low

823307

JEM1
DnaJ-like chaperone JEM1

1

0

High-throughput

0.232

Low

893359

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

0

High-throughput

0.232

Low

1050255

TAF9
SAGA complex/transcription factor TFIID complex subunit TAF9

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025