HitPredict

Interactor 1: GNAZ (P19086)
Guanine nucleotide-binding protein G(z) subunit alpha (G(x) alpha chain) (Gz-alpha)
Gene: GNAZ

Interactor 2: P2RY8 (Q86VZ1)
P2Y purinoceptor 8 (P2Y8)
Gene: P2RY8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	7tm_1~G-alpha
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 355 Hs			1 359
+	Hs
		391305 GNAI2_HUMAN (1-354): 2.1e-177: 497: 66.38		ADRB2_HUMAN (4-332): 2.82e-71: 229: 15.88
+	Hs
		670446 GNA11_HUMAN (1-354): 4.25e-164: 464: 46.76		CXCR4_HUMAN (23-308): 3.55e-84: 261: 25.26
+	Hs
		429011 GNAI1_HUMAN (1-354): 9.58e-177: 495: 67.23		ADRB2_HUMAN (4-332): 2.82e-71: 229: 15.88
+	Hs
		428884 GNAI3_HUMAN (1-354): 5.24e-174: 489: 67.23		ADRB2_HUMAN (4-332): 2.82e-71: 229: 15.88
+	Hs
		837623 GNAQ_HUMAN (1-354): 1.59e-167: 472: 47.89		P2RY8_HUMAN (1-359): 1.75e-78: 246: 100.00
+	Hs
		926680 GNAI1_HUMAN (1-354): 9.58e-177: 495: 67.23		MTR1L_HUMAN (13-340): 7.16e-65: 218: 19.16
+	Hs
		450979 GNAO_HUMAN (1-354): 2.98e-175: 492: 60.45		OPRM_HUMAN (12-356): 5.97e-67: 218: 22.51
+	Hs
		391347 GNAI2_HUMAN (1-354): 2.1e-177: 497: 66.38		OPRD_HUMAN (5-338): 7.14e-65: 211: 24.05
+	Hs
		895622 GNA13_HUMAN (2-354): 1.24e-156: 446: 39.17		CXCR4_HUMAN (23-308): 3.55e-84: 261: 25.26
+	Hs
		450984 GNAO_HUMAN (1-354): 2.98e-175: 492: 60.45		OPRD_HUMAN (5-338): 7.14e-65: 211: 24.05
+	Hs
		429010 GNAS2_HUMAN (1-354): 2.36e-167: 473: 37.22		ADRB2_HUMAN (4-332): 2.82e-71: 229: 15.88
+	Hs
		428911 GNAT2_HUMAN (1-354): 3.65e-167: 471: 57.06		ADRB2_HUMAN (4-332): 2.82e-71: 229: 15.88
+	Hs
		391334 GNAI2_HUMAN (1-354): 2.1e-177: 497: 66.38		PAR1_HUMAN (22-311): 2.6e-56: 191: 36.64
+	Hs
		674835 GNAQ_HUMAN (1-354): 1.59e-167: 472: 47.89		AGTR1_HUMAN (18-345): 2.09e-66: 215: 23.08
+	Hs
		686617 GNAQ_HUMAN (1-354): 1.59e-167: 472: 47.89		CCR1_HUMAN (23-346): 1.52e-66: 215: 21.82
+	Hs
		626831 GNAQ_HUMAN (1-354): 1.59e-167: 472: 47.89		PAR1_HUMAN (22-311): 2.6e-56: 191: 36.64
+	Hs
		686657 GNA13_HUMAN (2-354): 1.24e-156: 446: 39.17		CCR1_HUMAN (23-346): 1.52e-66: 215: 21.82
+	Hs
		626836 GNA13_HUMAN (2-354): 1.24e-156: 446: 39.17		PAR1_HUMAN (22-311): 2.6e-56: 191: 36.64
+	Hs
		670432 GNA11_HUMAN (1-354): 4.25e-164: 464: 46.76		P2RY1_HUMAN (26-304): 3.46e-38: 142: 29.97
+	Hs
		926646 GNAS2_HUMAN (1-354): 2.36e-167: 473: 37.22		CLTR2_HUMAN (26-308): 3.37e-28: 114: 28.57