HitPredict

Interactor 1: ML12A (P19105)
Myosin regulatory light chain 12A (Epididymis secretory protein Li 24) (HEL-S-24) (MLC-2B) (Myosin RLC) (Myosin regulatory light chain 2, nonsarcomeric) (Myosin regulatory light chain MRLC3)
Gene: MYL12A

Interactor 2: MYL6 (P60660)
Myosin light polypeptide 6 (17 kDa myosin light chain) (LC17) (Myosin light chain 3) (MLC-3) (Myosin light chain alkali 3) (Myosin light chain A3) (Smooth muscle and nonmuscle myosin light chain alkali 6)
Gene: MYL6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005509 - calcium ion binding GO:0005829 - cytosol GO:0016459 - myosin complex GO:0070062 - extracellular exosome
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 171 Hs			1 151
+	Hs
		409446 ML12A_HUMAN (1-171): 2.06e-65: 199: 100.00		MYL1_HUMAN (3-150): 1.84e-56: 176: 74.32
+	Hs
		538637 ML12A_HUMAN (1-171): 2.06e-65: 199: 100.00		MYL6B_HUMAN (3-150): 2.63e-42: 141: 81.76
+	Hs
		159536 ML12B_HUMAN (13-171): 4.64e-65: 198: 99.37		MYL6B_HUMAN (3-150): 2.63e-42: 141: 81.76
+	Hs
		538639 MYL9_HUMAN (14-171): 2.29e-64: 196: 94.30		MYL6B_HUMAN (3-150): 2.63e-42: 141: 81.76
+	Hs
		159559 ML12B_HUMAN (13-171): 4.64e-65: 198: 99.37		MYL6_HUMAN (1-151): 9.61e-42: 137: 100.00
+	Hs
		624346 MYL9_HUMAN (14-171): 2.29e-64: 196: 94.30		MYL6_HUMAN (1-151): 9.61e-42: 137: 100.00
+	Ce
		585992 MLR1_CAEEL (23-169): 2.25e-39: 133: 49.32		MLE_CAEEL (12-151): 6.35e-36: 123: 46.43
+	Ce
		585996 MLR2_CAEEL (23-169): 1.93e-39: 133: 49.32		MLE_CAEEL (12-151): 6.35e-36: 123: 46.43
+	Hs
		409438 CALM1_HUMAN (16-92): 3.58e-09: 54.5: 24.69		MYL1_HUMAN (3-150): 1.84e-56: 176: 74.32
+	Hs
		483897 CALM1_HUMAN (16-92): 3.58e-09: 54.5: 24.69		MYL6B_HUMAN (3-150): 2.63e-42: 141: 81.76
+	Hs
		483970 CALM2_HUMAN (16-92): 3.58e-09: 54.5: 24.69		MYL6B_HUMAN (3-150): 2.63e-42: 141: 81.76
+	Hs
		483988 CALM2_HUMAN (16-92): 3.58e-09: 54.5: 24.69		MYL6_HUMAN (1-151): 9.61e-42: 137: 100.00
+	At
		886540 CALM6_ARATH (96-170): 1.06e-16: 74.1: 25.33		CALM7_ARATH (5-77): 2.96e-11: 59.4: 27.40
+	At
		989458 CDPK1_ARATH (38-171): 3.35e-14: 71.1: 17.99		CDPK1_ARATH (73-150): 1e-09: 57.5: 21.52
+	At
		1104924 CDPK4_ARATH (36-171): 9.35e-14: 69.9: 18.37		CDPK4_ARATH (73-150): 3.27e-09: 56: 22.79
+	At
		1105900 CDPKB_ARATH (95-171): 8.73e-13: 66.8: 24.68		CDPKB_ARATH (73-150): 4.48e-09: 55.6: 22.79
+	Hs
		483903 CALL3_HUMAN (31-92): 1.25e-10: 58.2: 27.27		CALM1_HUMAN (5-77): 1.13e-11: 60.6: 28.77
+	Hs
		483976 CALL3_HUMAN (31-92): 1.25e-10: 58.2: 27.27		CALM2_HUMAN (5-77): 1.13e-11: 60.6: 28.77