Protein: PSA
Puromycin-sensitive aminopeptidase (PSA) (EC 3.4.11.14) (Cytosol alanyl aminopeptidase) (AAP-S)

Gene: PSA, NPEPPS
Organism: Homo sapiens
Interactions: 156
UniProt ID: P55786

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0004177 - aminopeptidase activity
GO:0005615 - extracellular space
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

563488

CFTR
Cystic fibrosis transmembrane conductance regulator

3

3

High-throughput

0.650

High

938574

LRC8E
Volume-regulated anion channel subunit LRRC8E

2

4

High-throughput

0.628

High

938544

PSA
Puromycin-sensitive aminopeptidase

1

7

High-throughput

0.618

High

938563

CUL3
Cullin-3

2

2

High-throughput

0.611

High

529438

TAU
Microtubule-associated protein tau

2

2

Small-scale

0.585

High

241218

PRKN
E3 ubiquitin-protein ligase parkin

2

2

High-throughput

0.584

High

536837

HSP7C
Heat shock cognate 71 kDa protein

2

1

High-throughput

0.584

High

861958

YAP1
Transcriptional coactivator YAP1

2

1

High-throughput

0.584

High

938554

CAV1
Caveolin-1

2

2

High-throughput

0.571

High

585778

PHKG2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

1

1

High-throughput

0.536

High

749882

KINH
Kinesin-1 heavy chain

1

1

High-throughput

0.536

High

938551

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

1

High-throughput

0.536

High

938553

OTUD4
OTU domain-containing protein 4

1

1

High-throughput

0.536

High

938555

KLC1
Kinesin light chain 1

1

1

High-throughput

0.536

High

938556

DMWD
Dystrophia myotonica WD repeat-containing protein

1

1

High-throughput

0.536

High

938558

KIF5A
Kinesin heavy chain isoform 5A

1

1

High-throughput

0.536

High

938577

LRC8B
Volume-regulated anion channel subunit LRRC8B

1

4

High-throughput

0.536

High

938581

LRC8D
Volume-regulated anion channel subunit LRRC8D

1

4

High-throughput

0.536

High

938585

LRC8A
Volume-regulated anion channel subunit LRRC8A

1

4

High-throughput

0.536

High

938599

LRC8C
Volume-regulated anion channel subunit LRRC8C

1

4

High-throughput

0.536

High

938641

SAR1B
Small COPII coat GTPase SAR1B

1

4

High-throughput

0.536

High

329830

SNX4
Sorting nexin-4

1

0

High-throughput

0.513

High

938560

CLN3
Battenin

1

0

High-throughput

0.513

High

938568

MYLK
Myosin light chain kinase, smooth muscle

1

0

High-throughput

0.513

High

938584

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

938587

TCAL8
Transcription elongation factor A protein-like 8

1

0

High-throughput

0.513

High

938597

RIN3
Ras and Rab interactor 3

1

0

High-throughput

0.513

High

938616

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

0

High-throughput

0.513

High

938625

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

High-throughput

0.513

High

353155

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.493

High

830426

CCNF
Cyclin-F

1

0

High-throughput

0.493

High

938545

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.493

High

938567

P2RY6
P2Y purinoceptor 6

1

7

High-throughput

0.489

High

142917

NFIB
Nuclear factor 1 B-type

1

2

High-throughput

0.479

High

189483

STX7
Syntaxin-7

1

2

High-throughput

0.479

High

293435

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.479

High

370175

CYTN
Cystatin-SN

1

1

Small-scale

0.479

High

371579

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

379968

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

3

High-throughput

0.479

High

400550

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

3

High-throughput

0.479

High

469040

SRPRA
Signal recognition particle receptor subunit alpha

1

1

High-throughput

0.479

High

473887

NFIC
Nuclear factor 1 C-type

1

2

High-throughput

0.479

High

588322

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

606509

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

609973

VGFR1
Vascular endothelial growth factor receptor 1

1

2

High-throughput

0.479

High

615688

RL17
Large ribosomal subunit protein uL22

1

2

High-throughput

0.479

High

695049

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

699666

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

2

High-throughput

0.479

High

761199

RYK
Tyrosine-protein kinase RYK

1

4

Small-scale

0.479

High

766354

PHB1
Prohibitin 1

1

4

High-throughput

0.479

High

798906

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.479

High

876794

KC1A
Casein kinase I isoform alpha

1

1

High-throughput

0.479

High

883191

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

2

High-throughput

0.479

High

891405

GSK3B
Glycogen synthase kinase-3 beta

1

3

High-throughput

0.479

High

907350

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

1

High-throughput

0.479

High

929858

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

1

High-throughput

0.479

High

934334

TERA
Transitional endoplasmic reticulum ATPase

1

3

High-throughput

0.479

High

938546

CTBP2
C-terminal-binding protein 2

1

1

High-throughput

0.479

High

938548

WDR5
WD repeat-containing protein 5

1

1

High-throughput

0.479

High

938550

ARF6
ADP-ribosylation factor 6

1

2

High-throughput

0.479

High

938552

VIGLN
Vigilin

1

2

High-throughput

0.479

High

938559

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

1

High-throughput

0.479

High

938564

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

1

High-throughput

0.479

High

938565

NFIX
Nuclear factor 1 X-type

1

2

High-throughput

0.479

High

938566

CUL7
Cullin-7

1

1

High-throughput

0.479

High

938575

ZN746
Zinc finger protein 746

1

1

High-throughput

0.479

High

938578

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

938588

CDK20
Cyclin-dependent kinase 20

1

1

Small-scale

0.479

High

938592

EMC1
ER membrane protein complex subunit 1

1

1

High-throughput

0.479

High

938601

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

938602

TP4A1
Protein tyrosine phosphatase type IVA 1

1

1

High-throughput

0.479

High

938610

SNX27
Sorting nexin-27

1

1

High-throughput

0.479

High

938612

RUFY1
RUN and FYVE domain-containing protein 1

1

3

High-throughput

0.479

High

938613

DUS23
Dual specificity protein phosphatase 23

1

1

High-throughput

0.479

High

938614

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

1

High-throughput

0.479

High

938615

YTHD1
YTH domain-containing family protein 1

1

1

High-throughput

0.479

High

938617

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

1

High-throughput

0.479

High

938621

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.479

High

938626

RHOF
Rho-related GTP-binding protein RhoF

1

11

High-throughput

0.479

High

938629

FBX6
F-box only protein 6

1

6

High-throughput

0.479

High

938632

WWOX
WW domain-containing oxidoreductase

1

1

High-throughput

0.479

High

938633

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

938636

HDAC5
Histone deacetylase 5

1

2

High-throughput

0.479

High

938639

TRAF6
TNF receptor-associated factor 6

1

2

High-throughput

0.479

High

938640

YTHD2
YTH domain-containing family protein 2

1

1

High-throughput

0.479

High

345571

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

349897

SNAI1
Zinc finger protein SNAI1

1

0

High-throughput

0.458

High

377194

SOMA
Somatotropin

1

0

High-throughput

0.458

High

413494

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

557990

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.458

High

590846

TIMP2
Metalloproteinase inhibitor 2

1

0

High-throughput

0.458

High

659417

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.458

High

667687

CDK2
Cyclin-dependent kinase 2

1

0

High-throughput

0.458

High

702086

ITPI2
Protein ITPRID2

1

0

High-throughput

0.458

High

718787

CCND2
G1/S-specific cyclin-D2

1

0

Small-scale

0.458

High

872118

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

919839

PLK1
Serine/threonine-protein kinase PLK1

1

0

High-throughput

0.458

High

938547

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

938549

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

938557

TFCP2
Alpha-globin transcription factor CP2

1

0

High-throughput

0.458

High

938561

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

938562

MTMR1
Phosphatidylinositol-3-phosphate phosphatase MTMR1

1

0

High-throughput

0.458

High

938569

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

938572

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.458

High

938582

CMKMT
Calmodulin-lysine N-methyltransferase

1

0

High-throughput

0.458

High

938589

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.458

High

938590

PLD6
Mitochondrial cardiolipin hydrolase

1

0

High-throughput

0.458

High

938593

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

938594

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

938596

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

938598

FBX25
F-box only protein 25

1

0

High-throughput

0.458

High

938600

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

938605

ARMC5
Armadillo repeat-containing protein 5

1

0

High-throughput

0.458

High

938606

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.458

High

938608

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

938611

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

938618

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.458

High

938619

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

938622

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

938623

ECT2
Protein ECT2

1

0

High-throughput

0.458

High

938628

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

0

High-throughput

0.458

High

938631

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

938634

TRI33
E3 ubiquitin-protein ligase TRIM33

1

0

High-throughput

0.458

High

938637

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

0

High-throughput

0.458

High

938638

LOXL2
Lysyl oxidase homolog 2

1

0

High-throughput

0.458

High

171425

S27A2
Long-chain fatty acid transport protein 2

1

3

High-throughput

0.445

High

429597

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

626135

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

3

High-throughput

0.445

High

652181

GTR5
Solute carrier family 2, facilitated glucose transporter member 5

1

3

High-throughput

0.445

High

938571

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.445

High

938573

A16L1
Autophagy-related protein 16-1

1

6

High-throughput

0.445

High

938576

S27A4
Long-chain fatty acid transport protein 4

1

3

High-throughput

0.445

High

938583

SPNS2
Sphingosine-1-phosphate transporter SPNS2

1

2

High-throughput

0.445

High

938591

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

1

High-throughput

0.445

High

938604

S67A1
Solute carrier family 67 member A1

1

1

High-throughput

0.445

High

938630

S22AB
Solute carrier family 22 member 11

1

5

High-throughput

0.445

High

938635

XCT
Cystine/glutamate transporter

1

2

High-throughput

0.445

High

105656

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

411661

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.437

High

767813

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

786992

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

1

High-throughput

0.437

High

938609

RHOV
Rho-related GTP-binding protein RhoV

1

10

High-throughput

0.437

High

938570

S45A4
Solute carrier family 45 member 4

1

0

High-throughput

0.426

High

938586

S35F3
Solute carrier family 35 member F3

1

0

High-throughput

0.426

High

886682

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

938580

S35D2
Nucleotide sugar transporter SLC35D2

1

1

High-throughput

0.407

High

938595

MOT11
Monocarboxylate transporter 11

1

2

High-throughput

0.407

High

938603

S35B4
Nucleotide sugar transporter SLC35B4

1

1

High-throughput

0.407

High

938620

S35B3
Adenosine 3'-phospho 5'-phosphosulfate transporter 2

1

2

High-throughput

0.407

High

938627

SO1B3
Solute carrier organic anion transporter family member 1B3

1

1

High-throughput

0.407

High

938607

FAF2
FAS-associated factor 2

2

0

High-throughput

0.318

High

276095

NIPS2
Protein NipSnap homolog 2

1

0

High-throughput

0.279

Low

938579

PAQR9
Membrane progestin receptor epsilon

1

0

Small-scale

0.249

Low

938624

F204A
Protein FAM204A

1

0

High-throughput

0.249

Low

990

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025