HitPredict

Interactor 1: RPB3 (P19387)
DNA-directed RNA polymerase II subunit RPB3 (RNA polymerase II subunit 3) (RNA polymerase II subunit B3) (DNA-directed RNA polymerase II 33 kDa polypeptide) (RPB33) (DNA-directed RNA polymerase II subunit C) (RPB31)
Gene: POLR2C

Interactor 2: RPB7 (P62487)
DNA-directed RNA polymerase II subunit RPB7 (RNA polymerase II subunit B7) (DNA-directed RNA polymerase II subunit G) (RNA polymerase II 19 kDa subunit) (RPB19)
Gene: POLR2G

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	0.60	0.737

Property	Details
Experiments	26496610, 28514442, 9201987, 33961781, 35271311, 24981860
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005665 - RNA polymerase II, core complex GO:0006366 - transcription by RNA polymerase II
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 275 Hs			1 172
+	Hs
		583639 RPB3_HUMAN (1-275): 6.89e-138: 391: 100.00		RPC8_HUMAN (1-172): 5.28e-54: 171: 18.72
+	Hs
		169827 RPAC1_HUMAN (3-269): 1.2e-110: 325: 25.90		RPB7_HUMAN (1-172): 1.48e-76: 227: 100.00
+	Sc
		557982 RPB3_YEAST (4-271): 9.52e-107: 313: 45.06		RPB7_YEAST (1-171): 4.45e-63: 193: 42.78
+	Sp
		145813 RPB3_SCHPO (9-275): 1.43e-99: 295: 43.89		RPB7_SCHPO (2-171): 1.24e-67: 205: 49.42
+	Hs
		169999 RPAC1_HUMAN (3-269): 1.2e-110: 325: 25.90		RPC8_HUMAN (1-172): 5.28e-54: 171: 18.72
+	Sc
		557993 RPB3_YEAST (4-271): 9.52e-107: 313: 45.06		RPC8_YEAST (1-158): 1.07e-49: 160: 19.39
+	Sc
		429676 RPAC1_YEAST (3-261): 1.36e-96: 288: 25.42		RPC8_YEAST (1-158): 1.07e-49: 160: 19.39