Protein: DEST
Destrin (Actin-depolymerizing factor) (ADF)

Gene: DEST, DSTN
Organism: Homo sapiens
Interactions: 102
UniProt ID: P60981

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0008154 - actin polymerization or depolymerization
GO:0015629 - actin cytoskeleton
GO:0030042 - actin filament depolymerization
GO:0030043 - actin filament fragmentation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

952697

ACTB
Actin, cytoplasmic 1

9

20

High-throughput

0.976

High

955818

ACTG
Actin, cytoplasmic 2

6

20

High-throughput

0.952

High

955868

COF2
Cofilin-2

3

12

High-throughput

0.839

High

660018

COF1
Cofilin-1

1

12

High-throughput

0.691

High

563517

CFTR
Cystic fibrosis transmembrane conductance regulator

4

5

High-throughput

0.691

High

955842

TAXB1
Tax1-binding protein 1

3

14

High-throughput

0.675

High

955836

Q549N0
Cofilin 2

1

12

High-throughput

0.665

High

440012

LCK
Tyrosine-protein kinase Lck

1

2

High-throughput

0.618

High

955817

ACTA
Actin, aortic smooth muscle

1

20

High-throughput

0.618

High

955819

ACTS
Actin, alpha skeletal muscle

1

20

High-throughput

0.618

High

955834

Q1KLZ0
HCG15971, isoform CRA_a

1

20

High-throughput

0.594

High

241254

PRKN
E3 ubiquitin-protein ligase parkin

2

8

High-throughput

0.584

High

277910

SH3L1
Adapter SH3BGRL

2

3

High-throughput

0.571

High

259705

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.553

High

123648

MYO1C
Unconventional myosin-Ic

1

11

High-throughput

0.536

High

336384

SVIL
Supervillin

1

1

High-throughput

0.536

High

361192

SODC
Superoxide dismutase [Cu-Zn]

1

1

High-throughput

0.536

High

529470

TAU
Microtubule-associated protein tau

1

7

High-throughput

0.536

High

608242

EGLN
Endoglin

1

1

High-throughput

0.536

High

728570

AKT2
RAC-beta serine/threonine-protein kinase

1

3

High-throughput

0.536

High

772706

MYH9
Myosin-9

1

4

High-throughput

0.536

High

920417

DAPK1
Death-associated protein kinase 1

1

6

High-throughput

0.536

High

955815

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

4

High-throughput

0.536

High

955827

SCRB2
Lysosome membrane protein 2

1

2

High-throughput

0.536

High

955849

MY18A
Unconventional myosin-XVIIIa

1

8

High-throughput

0.536

High

371613

MYC
Myc proto-oncogene protein

2

5

High-throughput

0.533

High

181874

SMAD9
Mothers against decapentaplegic homolog 9

1

1

High-throughput

0.508

High

955846

SSH1
Protein phosphatase Slingshot homolog 1

1

6

Small-scale

0.501

High

323267

TRI37
E3 ubiquitin-protein ligase TRIM37

1

11

High-throughput

0.479

High

324695

HEXI1
Protein HEXIM1

1

3

High-throughput

0.479

High

395791

ESR1
Estrogen receptor

1

4

High-throughput

0.479

High

408775

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

3

High-throughput

0.479

High

425413

ISG15
Ubiquitin-like protein ISG15

1

3

Small-scale

0.479

High

446823

NPM
Nucleophosmin

1

1

High-throughput

0.479

High

536865

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

629702

BTF3
Transcription factor BTF3

1

2

High-throughput

0.479

High

667696

CDK2
Cyclin-dependent kinase 2

1

1

High-throughput

0.479

High

887891

MCM2
DNA replication licensing factor MCM2

1

3

High-throughput

0.479

High

919852

PLK1
Serine/threonine-protein kinase PLK1

1

7

High-throughput

0.479

High

955822

UBE3A
Ubiquitin-protein ligase E3A

1

2

High-throughput

0.479

High

955824

G3BP1
Ras GTPase-activating protein-binding protein 1

1

1

High-throughput

0.479

High

955826

CUL3
Cullin-3

1

3

High-throughput

0.479

High

955828

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

4

High-throughput

0.479

High

955830

KIF14
Kinesin-like protein KIF14

1

3

High-throughput

0.479

High

955835

SMU1
WD40 repeat-containing protein SMU1

1

3

High-throughput

0.479

High

955840

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.479

High

955844

SERB1
SERPINE1 mRNA-binding protein 1

1

2

High-throughput

0.479

High

955847

TOPB1
DNA topoisomerase 2-binding protein 1

1

3

High-throughput

0.479

High

955848

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

3

High-throughput

0.479

High

955853

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.479

High

955854

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

955856

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.479

High

955857

PKHA4
Pleckstrin homology domain-containing family A member 4

1

14

High-throughput

0.479

High

955858

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

955860

ANLN
Anillin

1

3

High-throughput

0.479

High

955861

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.479

High

955865

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

955866

TNIK
TRAF2 and NCK-interacting protein kinase

1

3

High-throughput

0.479

High

955841

Q7KZS0
SUMO-conjugating enzyme UBC9

1

2

High-throughput

0.470

High

407798

SHBG
Sex hormone-binding globulin

1

0

Small-scale

0.460

High

720095

PURA2
Adenylosuccinate synthetase isozyme 2

1

0

High-throughput

0.458

High

774255

BASI
Basigin

1

0

High-throughput

0.458

High

955832

FSCN1
Fascin

1

0

High-throughput

0.458

High

955838

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.458

High

955869

DTX4
E3 ubiquitin-protein ligase DTX4

1

0

Small-scale

0.458

High

955845

TGFA1
Transforming growth factor-beta receptor-associated protein 1

1

5

High-throughput

0.445

High

955855

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

5

High-throughput

0.445

High

955867

COR2B
Coronin-2B

1

8

High-throughput

0.445

High

285165

EED
Polycomb protein EED

1

8

High-throughput

0.437

High

353174

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.437

High

405961

MYCN
N-myc proto-oncogene protein

1

5

High-throughput

0.437

High

897689

CDK9
Cyclin-dependent kinase 9

1

5

High-throughput

0.437

High

937682

FOXA1
Hepatocyte nuclear factor 3-alpha

1

1

High-throughput

0.437

High

955816

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.437

High

955829

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.437

High

955831

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.437

High

955837

VIR
Protein virilizer homolog

1

1

High-throughput

0.437

High

955843

FBXL6
F-box/LRR-repeat protein 6

1

2

High-throughput

0.437

High

955851

ESR2
Estrogen receptor beta

1

4

High-throughput

0.437

High

955862

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

2

High-throughput

0.437

High

955864

RRBP1
Ribosome-binding protein 1

1

7

High-throughput

0.437

High

955870

AAR2
Protein AAR2 homolog

1

1

High-throughput

0.437

High

326884

ARK73
Aldo-keto reductase family 7 member A3

1

0

High-throughput

0.426

High

955823

FMR1
Fragile X messenger ribonucleoprotein 1

1

0

High-throughput

0.426

High

955839

OLFM4
Olfactomedin-4

1

0

High-throughput

0.426

High

955863

SPHK1
Sphingosine kinase 1

1

0

Small-scale

0.426

High

429623

JUN
Transcription factor Jun

1

4

High-throughput

0.407

High

955825

RM49
Large ribosomal subunit protein mL49

1

1

High-throughput

0.407

High

298695

ATP5H
ATP synthase peripheral stalk subunit d, mitochondrial

1

0

High-throughput

0.269

Low

822558

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.251

Low

254574

EIF1B
Eukaryotic translation initiation factor 1b

1

0

High-throughput

0.249

Low

377196

SOMA
Somatotropin

1

0

High-throughput

0.249

Low

799824

COIL
Coilin

1

0

High-throughput

0.249

Low

941890

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.249

Low

955820

SARNP
SAP domain-containing ribonucleoprotein

1

0

High-throughput

0.249

Low

955821

SCN7A
Sodium channel protein type 7 subunit alpha

1

0

High-throughput

0.249

Low

955833

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.249

Low

955850

AKAP1
A-kinase anchor protein 1, mitochondrial

1

0

High-throughput

0.249

Low

955852

PINX1
PIN2/TERF1-interacting telomerase inhibitor 1

1

0

High-throughput

0.249

Low

955859

RPF2
Ribosome production factor 2 homolog

1

0

High-throughput

0.249

Low

955871

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

1

0

Small-scale

0.249

Low

955872

PCDG9
Protocadherin gamma-A9

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025