Protein: SIMC1
SUMO-interacting motif-containing protein 1 (Platform element for inhibition of autolytic degradation)

Gene: SIMC1
Organism: Homo sapiens
Interactions: 45
UniProt ID: Q8NDZ2

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0016605 - PML body
GO:0030017 - sarcomere
GO:0030414 - peptidase inhibitor activity
GO:0032184 - SUMO polymer binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1220336

SLF2
SMC5-SMC6 complex localization factor protein 2

2

0

High-throughput

0.631

High

1242771

SMC6
Structural maintenance of chromosomes protein 6

2

1

High-throughput

0.628

High

902678

SUMO2
Small ubiquitin-related modifier 2

2

1

Small-scale

0.613

High

1153786

KLH10
Kelch-like protein 10

2

0

High-throughput

0.602

High

1173351

RFPLB
Ret finger protein-like 4B

2

0

High-throughput

0.585

High

1242774

CAB45
45 kDa calcium-binding protein

2

0

High-throughput

0.585

High

1242779

C5AR2
C5a anaphylatoxin chemotactic receptor 2

2

1

High-throughput

0.574

High

668835

PML
Protein PML

2

0

High-throughput

0.559

High

904879

1433G
14-3-3 protein gamma

1

1

High-throughput

0.541

High

598981

FPR1
fMet-Leu-Phe receptor

1

2

High-throughput

0.536

High

1242770

NSE3
Non-structural maintenance of chromosomes element 3 homolog

1

1

High-throughput

0.536

High

1231829

PIAS4
E3 SUMO-protein ligase PIAS4

1

0

High-throughput

0.513

High

1242783

ZN451
E3 SUMO-protein ligase ZNF451

1

0

High-throughput

0.501

High

126622

P2Y10
Putative P2Y purinoceptor 10

1

2

High-throughput

0.489

High

172125

GP182
G-protein coupled receptor 182

1

2

High-throughput

0.489

High

795995

MAGA8
Melanoma-associated antigen 8

1

1

High-throughput

0.489

High

1031017

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

1

High-throughput

0.489

High

1242778

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

1

High-throughput

0.489

High

861849

PLK1
Serine/threonine-protein kinase PLK1

1

0

High-throughput

0.486

High

931746

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.486

High

927317

1433Z
14-3-3 protein zeta/delta

1

1

High-throughput

0.481

High

928143

SUMO1
Small ubiquitin-related modifier 1

1

1

Small-scale

0.479

High

1221576

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

295032

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

1033300

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

1

0

High-throughput

0.458

High

1042073

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1242782

ZMYM2
Zinc finger MYM-type protein 2

1

0

High-throughput

0.458

High

933532

TBA4A
Tubulin alpha-4A chain

1

1

High-throughput

0.457

High

1175042

TBA1A
Tubulin alpha-1A chain

1

1

High-throughput

0.445

High

1242776

WNK1
Serine/threonine-protein kinase WNK1

1

0

High-throughput

0.438

High

1037307

TBB3
Tubulin beta-3 chain

1

0

High-throughput

0.426

High

1242773

SLF1
SMC5-SMC6 complex localization factor protein 1

1

0

High-throughput

0.426

High

1242781

DJB11
DnaJ homolog subfamily B member 11

4

0

High-throughput

0.364

High

1242768

NSE1
Non-structural maintenance of chromosomes element 1 homolog

3

0

High-throughput

0.347

High

824724

NPY2R
Neuropeptide Y receptor type 2

2

0

High-throughput

0.328

High

1219938

BBS7
Bardet-Biedl syndrome 7 protein

2

0

High-throughput

0.328

High

586866

CSK22
Casein kinase II subunit alpha'

1

0

High-throughput

0.279

Low

971094

OC90
Otoconin-90

1

0

High-throughput

0.279

Low

1242769

I17RA
Interleukin-17 receptor A

1

0

High-throughput

0.279

Low

1242772

TCPQM
T-complex protein 1 subunit theta-like 2

1

0

High-throughput

0.279

Low

1242780

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low

1242784

NPTN
Neuroplastin

1

0

High-throughput

0.279

Low

1242767

COP1
E3 ubiquitin-protein ligase COP1

1

0

High-throughput

0.249

Low

1242775

DDX24
ATP-dependent RNA helicase DDX24

1

0

High-throughput

0.249

Low

1242777

SACA1
Sperm acrosome membrane-associated protein 1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024