HitPredict

Interactor 1: RPAB1 (P19388)
DNA-directed RNA polymerases I, II, and III subunit RPABC1 (RNA polymerases I, II, and III subunit ABC1) (DNA-directed RNA polymerase II 23 kDa polypeptide) (DNA-directed RNA polymerase II subunit E) (RPB5 homolog) (XAP4)
Gene: POLR2E

Interactor 2: RPB1 (P24928)
DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)
Gene: POLR2A

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.93 1.00 0.968

The method score is based on:

Property Details
Experiments 9201987, 35271311, 37682711, 19240132, 28514442, 24981860, 33961781
Identification Methods pull down, affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains RNA_pol_Rpb1_1~RNA_pol_Rpb5_C, RNA_pol_Rpb1_5~RNA_pol_Rpb5_C, RNA_pol_Rpb1_1~RNA_pol_Rpb5_N, RNA_pol_Rpb1_5~RNA_pol_Rpb5_N
Common GO terms GO:0001055 - RNA polymerase II activity
GO:0003677 - DNA binding
GO:0003899 - DNA-directed 5'-3' RNA polymerase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
and 2 others

more...
Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 210
Hs

1 1970
+ Bt
+ At
+ Sp
+ Sc
+ Hs
+ Sc
+ Sc
+ Hv
+ Hs
+ At
+ At
+ At
+ At
+ Hv

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Last updated: 15 Jul 2024