HitPredict

Interactor 1: TNR1A (P19438)
Tumor necrosis factor receptor superfamily member 1A (Tumor necrosis factor receptor 1) (TNF-R1) (Tumor necrosis factor receptor type I) (TNF-RI) (TNFR-I) (p55) (p60) (CD antigen CD120a) [Cleaved into: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)]
Gene: TNFRSF1A

Interactor 2: TRAF1 (Q13077)
TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6)
Gene: TRAF1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

Property	Details
Experiments	8565075, 7859281, 19287455
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0033209 - tumor necrosis factor-mediated signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 455 Hs			1 416
+	Hs
		584390 TNR1A_HUMAN (1-455): 1.34e-147: 430: 100.00		TRAF2_HUMAN (3-415): 4e-124: 370: 38.01
+	Mm
		626852 TNR1A_MOUSE (1-445): 4.25e-127: 377: 64.37		TRAF2_MOUSE (3-415): 3.91e-127: 378: 37.77
+	Hs
		584509 TNR1A_HUMAN (1-455): 1.34e-147: 430: 100.00		TRAF6_HUMAN (15-414): 1.57e-103: 318: 22.98
+	Hs
		738660 TNR3_HUMAN (11-328): 5.78e-63: 211: 24.85		TRAF1_HUMAN (1-416): 4.57e-172: 489: 100.00
+	Hs
		154352 TR10B_HUMAN (31-445): 1.86e-78: 252: 19.81		TRAF2_HUMAN (3-415): 4e-124: 370: 38.01
+	Hs
		1020849 TNR25_HUMAN (39-442): 1.12e-77: 249: 27.36		TRAF2_HUMAN (3-415): 4e-124: 370: 38.01
+	Hs
		121479 TR10A_HUMAN (51-445): 8.24e-66: 220: 17.57		TRAF2_HUMAN (3-415): 4e-124: 370: 38.01
+	Mm
		192583 TNR11_MOUSE (43-368): 3.3e-58: 203: 16.48		TRAF2_MOUSE (3-415): 3.91e-127: 378: 37.77
+	Hs
		738659 TNR3_HUMAN (11-328): 5.78e-63: 211: 24.85		TRAF2_HUMAN (3-415): 4e-124: 370: 38.01
+	Mm
		761805 TNR3_MOUSE (20-331): 1.61e-54: 189: 23.44		TRAF2_MOUSE (3-415): 3.91e-127: 378: 37.77
+	Mm
		192585 TNR11_MOUSE (43-368): 3.3e-58: 203: 16.48		TRAF6_MOUSE (15-414): 1.94e-101: 313: 22.51
+	Hs
		584394 TNR1A_HUMAN (1-455): 1.34e-147: 430: 100.00		TRAF3_HUMAN (3-262): 9.64e-11: 65.3: 15.77
+	Hs
		1024787 EDAR_HUMAN (27-450): 4e-77: 249: 14.32		TRAF3_HUMAN (3-262): 9.64e-11: 65.3: 15.77
+	Hs
		129536 TNR3_HUMAN (11-328): 5.78e-63: 211: 24.85		TRAF5_HUMAN (14-261): 1.36e-16: 83.8: 13.91
+	Hs
		738661 TNR3_HUMAN (11-328): 5.78e-63: 211: 24.85		TRAF3_HUMAN (3-262): 9.64e-11: 65.3: 15.77
+	Mm
		192584 TNR11_MOUSE (43-368): 3.3e-58: 203: 16.48		TRAF5_MOUSE (14-296): 7.86e-13: 71.9: 13.45
+	Mm
		192587 TNR11_MOUSE (43-368): 3.3e-58: 203: 16.48		TRAF3_MOUSE (1-262): 2.34e-12: 70.7: 16.37
+	Hs
		738694 TNR3_HUMAN (11-328): 5.78e-63: 211: 24.85		TRAF4_HUMAN (27-136): 3.55e-09: 60.3: 17.86
+	Mm
		838552 TNR3_MOUSE (20-331): 1.61e-54: 189: 23.44		TRAF5_MOUSE (14-296): 7.86e-13: 71.9: 13.45
+	Mm
		838553 TNR3_MOUSE (20-331): 1.61e-54: 189: 23.44		TRAF3_MOUSE (1-262): 2.34e-12: 70.7: 16.37