HitPredict

Interactor 1: TFEB (P19484)
Transcription factor EB (Class E basic helix-loop-helix protein 35) (bHLHe35)
Gene: TFEB

Interactor 2: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	33961781, 28514442
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019899 - enzyme binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 476 Hs			1 246
+	Hs
		585111 TFEB_HUMAN (1-476): 1.43e-98: 306: 100.00		1433E_HUMAN (3-243): 4.39e-144: 405: 65.43
+	Hs
		585113 TFEB_HUMAN (1-476): 1.43e-98: 306: 100.00		1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60
+	Hs
		585107 TFEB_HUMAN (1-476): 1.43e-98: 306: 100.00		1433T_HUMAN (3-244): 3.24e-127: 361: 81.82
+	Mm
		910264 TFE3_MOUSE (4-472): 5.71e-66: 223: 44.63		1433E_MOUSE (3-243): 4.39e-144: 405: 65.43
+	Hs
		252907 MITF_HUMAN (1-461): 1.67e-65: 221: 40.64		1433B_HUMAN (1-246): 3.48e-144: 404: 100.00
+	Hs
		585110 TFEB_HUMAN (1-476): 1.43e-98: 306: 100.00		1433G_HUMAN (3-246): 1.91e-109: 317: 75.40
+	Mm
		926809 TFE3_MOUSE (4-472): 5.71e-66: 223: 44.63		1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02
+	Mm
		1144939 TFE3_MOUSE (4-472): 5.71e-66: 223: 44.63		1433B_MOUSE (1-246): 5.56e-141: 396: 98.78
+	Hs
		252914 MITF_HUMAN (1-461): 1.67e-65: 221: 40.64		1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60
+	Hs
		585115 TFEB_HUMAN (1-476): 1.43e-98: 306: 100.00		1433F_HUMAN (4-244): 2.7e-107: 311: 75.51
+	Mm
		933128 TFE3_MOUSE (4-472): 5.71e-66: 223: 44.63		1433T_MOUSE (3-244): 9.37e-127: 360: 81.82
+	Hs
		585630 TFE3_HUMAN (4-472): 5.79e-65: 221: 44.65		1433T_HUMAN (3-244): 3.24e-127: 361: 81.82
+	Hs
		683723 MLXIP_HUMAN (33-350): 1.28e-35: 142: 14.71		1433B_HUMAN (1-246): 3.48e-144: 404: 100.00
+	Mm
		905346 TFE3_MOUSE (4-472): 5.71e-66: 223: 44.63		1433G_MOUSE (3-246): 1.91e-109: 317: 75.40
+	Hs
		252912 MITF_HUMAN (1-461): 1.67e-65: 221: 40.64		1433G_HUMAN (3-246): 1.91e-109: 317: 75.40
+	Hs
		585644 TFE3_HUMAN (4-472): 5.79e-65: 221: 44.65		1433G_HUMAN (3-246): 1.91e-109: 317: 75.40
+	Mm
		935516 TFE3_MOUSE (4-472): 5.71e-66: 223: 44.63		1433F_MOUSE (4-244): 8.67e-108: 312: 75.51
+	Hs
		252919 MITF_HUMAN (1-461): 1.67e-65: 221: 40.64		1433F_HUMAN (4-244): 2.7e-107: 311: 75.51
+	Mm
		250872 TFE3_MOUSE (4-472): 5.71e-66: 223: 44.63		1433S_MOUSE (3-234): 1.38e-97: 286: 68.38
+	Hs
		647289 MLXIP_HUMAN (33-350): 1.28e-35: 142: 14.71		1433T_HUMAN (3-244): 3.24e-127: 361: 81.82