Protein: TNAP3
Tumor necrosis factor alpha-induced protein 3 (TNF alpha-induced protein 3) (EC 2.3.2.-) (EC 3.4.19.12) (OTU domain-containing protein 7C) (Putative DNA-binding protein A20) (Zinc finger protein A20) [Cleaved into: A20p50; A20p37]

Gene: TNAP3, TNFAIP3
Organism: Homo sapiens
Interactions: 193
UniProt ID: P21580

Gene Ontology (top 5):
GO:0001922 - B-1 B cell homeostasis
GO:0002020 - protease binding
GO:0002237 - response to molecule of bacterial origin
GO:0002634 - regulation of germinal center formation
GO:0002677 - negative regulation of chronic inflammatory response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

507522

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

14

11

Small-scale

0.984

High

639186

TNAP3
Tumor necrosis factor alpha-induced protein 3

13

4

Small-scale

0.982

High

507076

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

2

11

High-throughput

0.811

High

639291

OTUD5
OTU domain-containing protein 5

2

4

High-throughput

0.811

High

639214

RD23A
UV excision repair protein RAD23 homolog A

2

10

High-throughput

0.783

High

639212

UB2D1
Ubiquitin-conjugating enzyme E2 D1

2

6

Small-scale

0.778

High

639247

TNIP1
TNFAIP3-interacting protein 1

15

16

Small-scale

0.763

High

639333

TRAF6
TNF receptor-associated factor 6

16

20

Small-scale

0.762

High

639262

TAXB1
Tax1-binding protein 1

11

11

Small-scale

0.758

High

639338

NEMO
NF-kappa-B essential modulator

9

14

Small-scale

0.757

High

377962

TNFA
Tumor necrosis factor

12

3

Small-scale

0.756

High

639226

TRAF2
TNF receptor-associated factor 2

9

19

Small-scale

0.755

High

639235

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

8

4

Small-scale

0.753

High

622516

TNR1A
Tumor necrosis factor receptor superfamily member 1A

7

7

Small-scale

0.740

High

639270

TNIP2
TNFAIP3-interacting protein 2

6

2

Small-scale

0.734

High

639288

RNF31
E3 ubiquitin-protein ligase RNF31

5

9

Small-scale

0.714

High

639224

1433F
14-3-3 protein eta

4

19

Small-scale

0.707

High

639195

1433B
14-3-3 protein beta/alpha

4

19

Small-scale

0.697

High

639220

1433Z
14-3-3 protein zeta/delta

4

19

Small-scale

0.696

High

639232

BIRC2
Baculoviral IAP repeat-containing protein 2

4

5

Small-scale

0.694

High

639323

TBK1
Serine/threonine-protein kinase TBK1

4

10

Small-scale

0.691

High

639332

RNF11
RING finger protein 11

4

4

Small-scale

0.690

High

167821

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

4

6

Small-scale

0.683

High

639335

RN114
E3 ubiquitin-protein ligase RNF114

3

14

Small-scale

0.683

High

639199

TRI23
E3 ubiquitin-protein ligase TRIM23

3

8

High-throughput

0.675

High

639283

ARRD3
Arrestin domain-containing protein 3

3

3

High-throughput

0.675

High

639245

CASP8
Caspase-8

3

6

Small-scale

0.674

High

639260

AN13D
Ankyrin repeat domain-containing protein 13D

3

12

Small-scale

0.669

High

639293

TNIP3
TNFAIP3-interacting protein 3

3

11

Small-scale

0.668

High

639273

SHKB1
SH3KBP1-binding protein 1

3

8

High-throughput

0.662

High

639227

TRAF1
TNF receptor-associated factor 1

3

11

Small-scale

0.661

High

639228

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

3

18

Small-scale

0.658

High

639229

FADD
FAS-associated death domain protein

3

11

Small-scale

0.656

High

639216

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

6

Small-scale

0.647

High

639218

1433E
14-3-3 protein epsilon

3

1

Small-scale

0.642

High

639202

MTOR
Serine/threonine-protein kinase mTOR

3

7

Small-scale

0.640

High

639223

TF65
Transcription factor p65

3

8

Small-scale

0.640

High

639217

1433G
14-3-3 protein gamma

2

19

High-throughput

0.639

High

639309

SHRPN
Sharpin

2

2

Small-scale

0.635

High

639207

GSK3B
Glycogen synthase kinase-3 beta

2

4

Small-scale

0.634

High

639296

M3K5
Mitogen-activated protein kinase kinase kinase 5

2

14

Small-scale

0.634

High

557089

SRC
Proto-oncogene tyrosine-protein kinase Src

2

1

High-throughput

0.628

High

639282

RN166
E3 ubiquitin-protein ligase RNF166

2

18

High-throughput

0.628

High

639284

AIDA
Axin interactor, dorsalization-associated protein

2

1

High-throughput

0.628

High

639294

NED4L
E3 ubiquitin-protein ligase NEDD4-like

2

5

High-throughput

0.628

High

639310

BACD3
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

2

6

High-throughput

0.628

High

639328

TBC24
TBC1 domain family member 24

2

8

High-throughput

0.628

High

639334

ARI1
E3 ubiquitin-protein ligase ARIH1

2

8

High-throughput

0.628

High

639329

UBQL1
Ubiquilin-1

1

7

Small-scale

0.621

High

639303

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

2

8

Small-scale

0.614

High

639322

MALT1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1

2

4

Small-scale

0.611

High

639272

LNX1
E3 ubiquitin-protein ligase LNX

2

7

High-throughput

0.606

High

639318

RN216
E3 ubiquitin-protein ligase RNF216

2

7

High-throughput

0.606

High

639236

LAPM5
Lysosomal-associated transmembrane protein 5

2

0

Small-scale

0.605

High

639187

USF1
Upstream stimulatory factor 1

2

3

Small-scale

0.601

High

639241

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

2

13

Small-scale

0.601

High

249423

ACSL4
Long-chain-fatty-acid--CoA ligase 4

2

4

Small-scale

0.584

High

639233

SQSTM
Sequestosome-1

2

6

Small-scale

0.584

High

639238

CUL3
Cullin-3

2

7

Small-scale

0.584

High

353670

DRC4
Dynein regulatory complex subunit 4

2

0

High-throughput

0.580

High

639317

RNF12
E3 ubiquitin-protein ligase RLIM

2

2

High-throughput

0.576

High

608825

PFKAL
ATP-dependent 6-phosphofructokinase, liver type

1

2

Small-scale

0.573

High

639264

CCD50
Coiled-coil domain-containing protein 50

1

2

Small-scale

0.573

High

349793

SNAI1
Zinc finger protein SNAI1

1

9

Small-scale

0.561

High

606216

CEBPB
CCAAT/enhancer-binding protein beta

1

1

Small-scale

0.561

High

639266

RN168
E3 ubiquitin-protein ligase RNF168

1

2

Small-scale

0.561

High

413181

P53
Cellular tumor antigen p53

2

0

Small-scale

0.559

High

639285

TIFA
TRAF-interacting protein with FHA domain-containing protein A

1

0

Small-scale

0.537

High

244132

KIF5C
Kinesin heavy chain isoform 5C

1

8

High-throughput

0.536

High

389791

TTHY
Transthyretin

1

1

High-throughput

0.536

High

639188

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

3

High-throughput

0.536

High

639198

MYH11
Myosin-11

1

3

High-throughput

0.536

High

639201

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

4

High-throughput

0.536

High

639204

AFAM
Afamin

1

3

High-throughput

0.536

High

639209

S26A2
Sulfate transporter

1

1

High-throughput

0.536

High

639230

G3BP1
Ras GTPase-activating protein-binding protein 1

1

4

High-throughput

0.536

High

639255

A16L1
Autophagy-related protein 16-1

1

7

High-throughput

0.536

High

639279

TANK
TRAF family member-associated NF-kappa-B activator

1

1

High-throughput

0.536

High

639287

OPTN
Optineurin

1

16

High-throughput

0.536

High

639319

RCC2
Protein RCC2

1

4

High-throughput

0.536

High

639271

DPTOR
DEP domain-containing mTOR-interacting protein

1

1

Small-scale

0.523

High

177795

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

10

Small-scale

0.515

High

639211

IRAK1
Interleukin-1 receptor-associated kinase 1

1

1

Small-scale

0.515

High

639263

TCAM1
TIR domain-containing adapter molecule 1

1

1

Small-scale

0.515

High

639280

IRF7
Interferon regulatory factor 7

1

3

Small-scale

0.515

High

326434

S1PR2
Sphingosine 1-phosphate receptor 2

1

0

High-throughput

0.513

High

639203

HUTH
Histidine ammonia-lyase

1

0

High-throughput

0.513

High

639249

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

1

0

High-throughput

0.513

High

639313

AZI2
5-azacytidine-induced protein 2

1

0

High-throughput

0.513

High

639315

SPCS
O-phosphoseryl-tRNA(Sec) selenium transferase

1

0

High-throughput

0.513

High

639250

OCLN
Occludin

1

2

Small-scale

0.512

High

639312

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

9

Small-scale

0.504

High

639208

KLK7
Kallikrein-7

1

1

High-throughput

0.489

High

639225

GALT1
Polypeptide N-acetylgalactosaminyltransferase 1

1

1

High-throughput

0.489

High

639243

HABP2
Factor VII-activating protease

1

4

High-throughput

0.489

High

639253

SDK2
Protein sidekick-2

1

1

High-throughput

0.489

High

639258

LRC69
Leucine-rich repeat-containing protein 69

1

10

High-throughput

0.489

High

639265

SPA12
Serpin A12

1

3

High-throughput

0.489

High

639269

DIK2A
Divergent protein kinase domain 2A

1

1

High-throughput

0.489

High

639278

PCSK5
Proprotein convertase subtilisin/kexin type 5

1

4

High-throughput

0.489

High

639289

MMAB
Corrinoid adenosyltransferase MMAB

1

1

High-throughput

0.489

High

165256

PSA7
Proteasome subunit alpha type-7

1

5

Small-scale

0.481

High

279021

TRIM3
Tripartite motif-containing protein 3

1

12

High-throughput

0.481

High

418591

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

5

Small-scale

0.481

High

578610

FABP4
Fatty acid-binding protein, adipocyte

1

3

Small-scale

0.481

High

639190

1433T
14-3-3 protein theta

1

19

Small-scale

0.481

High

639215

RS20
Small ribosomal subunit protein uS10

1

2

Small-scale

0.481

High

639219

RS15
Small ribosomal subunit protein uS19

1

1

Small-scale

0.481

High

639240

GIT2
ARF GTPase-activating protein GIT2

1

13

High-throughput

0.481

High

639248

PCBP1
Poly(rC)-binding protein 1

1

7

Small-scale

0.481

High

639277

PIBF1
Progesterone-induced-blocking factor 1

1

1

High-throughput

0.481

High

639297

RNF5
E3 ubiquitin-protein ligase RNF5

1

5

High-throughput

0.481

High

639299

ZN251
Zinc finger protein 251

1

2

Small-scale

0.481

High

639304

TRIM8
E3 ubiquitin-protein ligase TRIM8

1

12

High-throughput

0.481

High

639305

UBXN6
UBX domain-containing protein 6

1

1

Small-scale

0.481

High

639306

TRIM5
Tripartite motif-containing protein 5

1

3

High-throughput

0.481

High

639307

TRIM2
Tripartite motif-containing protein 2

1

11

High-throughput

0.481

High

639321

RNF14
E3 ubiquitin-protein ligase RNF14

1

7

High-throughput

0.481

High

127633

TR10A
Tumor necrosis factor receptor superfamily member 10A

1

7

Small-scale

0.479

High

130377

SPT5H
Transcription elongation factor SPT5

1

5

Small-scale

0.479

High

163239

TR10B
Tumor necrosis factor receptor superfamily member 10B

1

7

Small-scale

0.479

High

169946

AURKA
Aurora kinase A

1

6

Small-scale

0.479

High

181054

AXIN1
Axin-1

1

2

Small-scale

0.479

High

210172

IRAK2
Interleukin-1 receptor-associated kinase-like 2

1

1

Small-scale

0.479

High

219841

SMAD6
Mothers against decapentaplegic homolog 6

1

3

Small-scale

0.479

High

345043

RIGI
Antiviral innate immune response receptor RIG-I

1

9

Small-scale

0.479

High

461144

HS90A
Heat shock protein HSP 90-alpha

1

4

High-throughput

0.479

High

468065

HS90B
Heat shock protein HSP 90-beta

1

4

High-throughput

0.479

High

562557

RINI
Ribonuclease inhibitor

1

4

High-throughput

0.479

High

626064

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

17

Small-scale

0.479

High

639192

GRN
Progranulin

1

1

Small-scale

0.479

High

639193

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

1

7

High-throughput

0.479

High

639194

AKT1
RAC-alpha serine/threonine-protein kinase

1

6

Small-scale

0.479

High

639196

1433S
14-3-3 protein sigma

1

19

High-throughput

0.479

High

639197

CTNB1
Catenin beta-1

1

8

Small-scale

0.479

High

639200

STAT3
Signal transducer and activator of transcription 3

1

4

Small-scale

0.479

High

639206

AL9A1
4-trimethylaminobutyraldehyde dehydrogenase

1

5

High-throughput

0.479

High

639210

TNF10
Tumor necrosis factor ligand superfamily member 10

1

3

Small-scale

0.479

High

639213

KIF11
Kinesin-like protein KIF11

1

9

High-throughput

0.479

High

639221

GSTO1
Glutathione S-transferase omega-1

1

2

Small-scale

0.479

High

639222

NFKB2
Nuclear factor NF-kappa-B p100 subunit

1

15

Small-scale

0.479

High

639231

BIRC3
Baculoviral IAP repeat-containing protein 3

1

4

Small-scale

0.479

High

639234

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

7

Small-scale

0.479

High

639237

KRR1
KRR1 small subunit processome component homolog

1

1

Small-scale

0.479

High

639239

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

10

High-throughput

0.479

High

639242

BECN1
Beclin-1

1

1

Small-scale

0.479

High

639244

MCM6
DNA replication licensing factor MCM6

1

6

High-throughput

0.479

High

639254

PP6R3
Serine/threonine-protein phosphatase 6 regulatory subunit 3

1

5

High-throughput

0.479

High

639256

RICTR
Rapamycin-insensitive companion of mTOR

1

1

Small-scale

0.479

High

639259

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.479

High

639267

AN13A
Ankyrin repeat domain-containing protein 13A

1

8

Small-scale

0.479

High

639274

NEK7
Serine/threonine-protein kinase Nek7

1

8

Small-scale

0.479

High

639276

CNKR2
Connector enhancer of kinase suppressor of ras 2

1

3

High-throughput

0.479

High

639292

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

6

Small-scale

0.479

High

639295

TRIB3
Tribbles homolog 3

1

4

Small-scale

0.479

High

639298

VRK1
Serine/threonine-protein kinase VRK1

1

6

High-throughput

0.479

High

639300

RIOK1
Serine/threonine-protein kinase RIO1

1

4

Small-scale

0.479

High

639301

RIOK2
Serine/threonine-protein kinase RIO2

1

4

Small-scale

0.479

High

639302

CAR11
Caspase recruitment domain-containing protein 11

1

7

Small-scale

0.479

High

639314

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

1

3

Small-scale

0.479

High

639320

PRGC1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

1

1

Small-scale

0.479

High

639324

XPO7
Exportin-7

1

6

High-throughput

0.479

High

639325

FBX3
F-box only protein 3

1

2

High-throughput

0.479

High

639327

TAOK2
Serine/threonine-protein kinase TAO2

1

12

Small-scale

0.479

High

639331

CSEN
Calsenilin

1

1

Small-scale

0.479

High

639337

STK24
Serine/threonine-protein kinase 24

1

6

Small-scale

0.479

High

639251

Q4G0R1
PIBF1 protein

1

1

High-throughput

0.470

High

384110

CO1A1
Collagen alpha-1(I) chain

1

0

Small-scale

0.460

High

353845

BCL10
B-cell lymphoma/leukemia 10

1

0

Small-scale

0.458

High

639290

PELI1
E3 ubiquitin-protein ligase pellino homolog 1

1

0

Small-scale

0.458

High

639316

TLR9
Toll-like receptor 9

1

0

Small-scale

0.458

High

639326

PLAT4
Phospholipase A and acyltransferase 4

1

0

Small-scale

0.458

High

639311

WNK1
Serine/threonine-protein kinase WNK1

1

5

High-throughput

0.457

High

69477

A2ML1
Alpha-2-macroglobulin-like protein 1

1

5

High-throughput

0.445

High

517284

ZTRF1
Zinc finger TRAF-type-containing protein 1

1

4

High-throughput

0.445

High

639205

PPCE
Prolyl endopeptidase

1

2

High-throughput

0.445

High

639252

KLH22
Kelch-like protein 22

1

1

High-throughput

0.445

High

639261

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

1

High-throughput

0.445

High

639275

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

7

Small-scale

0.445

High

598005

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

2

Small-scale

0.439

High

639257

CLC4G
C-type lectin domain family 4 member G

1

2

Small-scale

0.439

High

75655

B3KVV6
cDNA FLJ41607 fis, clone CTONG3001370, highly similar to Homo sapiens alpha-2-macroglobulin-like 1

1

5

High-throughput

0.437

High

639189

GCSP
Glycine dehydrogenase

1

1

High-throughput

0.437

High

639191

NDUS1
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

1

1

High-throughput

0.437

High

639268

LRC47
Leucine-rich repeat-containing protein 47

1

6

High-throughput

0.437

High

639330

XCT
Cystine/glutamate transporter

1

3

Small-scale

0.437

High

639336

PCDB5
Protocadherin beta-5

2

0

High-throughput

0.328

High

270431

FZD7
Frizzled-7

1

0

High-throughput

0.279

Low

639246

MELT
Ventricular zone-expressed PH domain-containing protein homolog 1

1

0

High-throughput

0.279

Low

639286

PKHB2
Pleckstrin homology domain-containing family B member 2

1

0

High-throughput

0.279

Low

639308

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

0

Small-scale

0.251

Low

639281

NAR4
Ecto-ADP-ribosyltransferase 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025