HitPredict

Interactor 1: PRP6 (P19735)
Pre-mRNA-splicing factor 6
Gene: PRP6

Interactor 2: LSM3 (P57743)
U6 snRNA-associated Sm-like protein LSm3 (SmX4 protein)
Gene: LSM3

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.678

Property	Details
Experiments	19740761, 37968396, 14759368, 16429126
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0005634 - nucleus GO:0005681 - spliceosomal complex GO:0046540 - U4/U6 x U5 tri-snRNP complex GO:0071001 - U4/U6 snRNP and 1 others more... GO:0071013 - catalytic step 2 spliceosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 899 Sc			1 89
+	Sc
		586429 PRP6_YEAST (1-899): 0: 558: 100.00		LSM7_YEAST (2-83): 1.07e-20: 80.6: 30.23
+	Sc
		586442 PRP6_YEAST (1-899): 0: 558: 100.00		SMD2_YEAST (4-76): 1.35e-20: 80.2: 30.67
+	Sc
		586410 PRP6_YEAST (1-899): 0: 558: 100.00		LSM5_YEAST (4-83): 2.79e-19: 76.4: 24.69
+	Hs
		300110 PRP6_HUMAN (2-895): 6.07e-177: 538: 25.44		RSMN_HUMAN (10-86): 1.36e-24: 93.7: 26.51
+	Hs
		300046 PRP6_HUMAN (2-895): 6.07e-177: 538: 25.44		RSMB_HUMAN (10-86): 3.53e-24: 92.9: 26.51
+	Hs
		300284 PRP6_HUMAN (2-895): 6.07e-177: 538: 25.44		LSM7_HUMAN (2-85): 7.35e-25: 91: 30.59
+	Hs
		300101 PRP6_HUMAN (2-895): 6.07e-177: 538: 25.44		LSM3_HUMAN (1-81): 7.88e-25: 90.6: 40.23
+	Hs
		300298 PRP6_HUMAN (2-895): 6.07e-177: 538: 25.44		LSM5_HUMAN (4-85): 3.22e-21: 81.4: 23.17
+	Hs
		300102 PRP6_HUMAN (2-895): 6.07e-177: 538: 25.44		LSM6_HUMAN (2-81): 5.33e-21: 80.2: 28.75
+	Hs
		300103 PRP6_HUMAN (2-895): 6.07e-177: 538: 25.44		SMD2_HUMAN (4-76): 1.47e-20: 80.2: 28.05
+	Hs
		300100 PRP6_HUMAN (2-895): 6.07e-177: 538: 25.44		RUXG_HUMAN (8-81): 2.24e-20: 78.7: 27.03
+	Sp
		1013603 PRP1_SCHPO (4-897): 2.68e-151: 470: 25.87		RSMB_SCHPO (12-86): 7.35e-21: 81.8: 28.05
+	Sp
		144206 PRP1_SCHPO (4-897): 2.68e-151: 470: 25.87		SMD2_SCHPO (4-77): 3.86e-19: 76.8: 26.83
+	Sc
		884838 CLF1_YEAST (222-440): 1.03e-13: 77.3: 14.41		LSM3_YEAST (1-89): 1.27e-28: 99.9: 100.00
+	Hs
		928016 CRNL1_HUMAN (687-884): 2.75e-15: 82.7: 13.93		RSMN_HUMAN (10-86): 1.36e-24: 93.7: 26.51
+	Hs
		539141 CRNL1_HUMAN (687-884): 2.75e-15: 82.7: 13.93		RSMB_HUMAN (10-86): 3.53e-24: 92.9: 26.51
+	Zm
		28403 A0A1D6JRD5_MAIZE (452-829): 1.82e-17: 89.6: 8.69		B4FDT9_MAIZE (4-76): 8.22e-21: 80.6: 28.05
+	Hs
		912106 CRNL1_HUMAN (687-884): 2.75e-15: 82.7: 13.93		RUXG_HUMAN (8-81): 2.24e-20: 78.7: 27.03
+	Sc
		865990 CLF1_YEAST (222-440): 1.03e-13: 77.3: 14.41		LSM7_YEAST (2-83): 1.07e-20: 80.6: 30.23
+	Sc
		768263 CLF1_YEAST (222-440): 1.03e-13: 77.3: 14.41		LSM5_YEAST (4-83): 2.79e-19: 76.4: 24.69