Protein: RAD51
DNA repair protein RAD51 homolog 1 (HsRAD51) (hRAD51) (RAD51 homolog A)

Gene: RAD51
Organism: Homo sapiens
Interactions: 225
UniProt ID: Q06609

Gene Ontology (top 5):
GO:0000150 - DNA strand exchange activity
GO:0000152 - nuclear ubiquitin ligase complex
GO:0000228 - nuclear chromosome
GO:0000722 - telomere maintenance via recombination
GO:0000724 - double-strand break repair via homologous recombination

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

904277

BRCA2
Breast cancer type 2 susceptibility protein

56

10

Small-scale

0.997

High

1055899

RAD51
DNA repair protein RAD51 homolog 1

23

18

Small-scale

0.989

High

1055913

DMC1
Meiotic recombination protein DMC1/LIM15 homolog

6

19

Small-scale

0.949

High

219948

XRCC3
DNA repair protein XRCC3

5

18

Small-scale

0.920

High

220058

XRCC2
DNA repair protein XRCC2

3

19

Small-scale

0.833

High

219074

RA51C
DNA repair protein RAD51 homolog 3

2

18

Small-scale

0.817

High

186328

RA51B
DNA repair protein RAD51 homolog 2

2

18

Small-scale

0.799

High

1055938

PALB2
Partner and localizer of BRCA2

15

3

Small-scale

0.763

High

413689

P53
Cellular tumor antigen p53

11

3

Small-scale

0.761

High

855431

ATRX
Transcriptional regulator ATRX

11

20

Small-scale

0.759

High

847989

RAD52
DNA repair protein RAD52 homolog

11

6

Small-scale

0.758

High

799026

BRCA1
Breast cancer type 1 susceptibility protein

11

5

Small-scale

0.757

High

1055951

R51A1
RAD51-associated protein 1

9

2

Small-scale

0.755

High

926337

BLM
RecQ-like DNA helicase BLM

9

14

Small-scale

0.754

High

1055927

FIGL1
Fidgetin-like protein 1

4

6

Small-scale

0.704

High

1055960

BARD1
BRCA1-associated RING domain protein 1

4

3

Small-scale

0.702

High

991304

SUMO1
Small ubiquitin-related modifier 1

4

2

Small-scale

0.694

High

695284

RFA1
Replication protein A 70 kDa DNA-binding subunit

4

3

Small-scale

0.687

High

993518

UBC9
SUMO-conjugating enzyme UBC9

4

5

Small-scale

0.681

High

362258

ABL1
Tyrosine-protein kinase ABL1

3

2

Small-scale

0.674

High

1056010

RA54B
DNA repair and recombination protein RAD54B

3

19

Small-scale

0.667

High

316283

RECQ5
ATP-dependent DNA helicase Q5

3

14

Small-scale

0.660

High

588534

RFA2
Replication protein A 32 kDa subunit

3

5

Small-scale

0.653

High

919907

PLK1
Serine/threonine-protein kinase PLK1

3

1

Small-scale

0.646

High

583856

UCHL3
Ubiquitin carboxyl-terminal hydrolase isozyme L3

2

1

Small-scale

0.639

High

1055912

WRN
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

2

14

Small-scale

0.634

High

1055914

MDC1
Mediator of DNA damage checkpoint protein 1

2

4

Small-scale

0.634

High

1055924

SWAP1
ATPase SWSAP1

2

4

Small-scale

0.634

High

703128

TEAD1
Transcriptional enhancer factor TEF-1

3

0

High-throughput

0.634

High

1055945

FBH1
F-box DNA helicase 1

3

0

Small-scale

0.623

High

1055941

FANCM
Fanconi anemia group M protein

1

8

Small-scale

0.618

High

1055905

SQSTM
Sequestosome-1

3

0

Small-scale

0.613

High

163090

CHK1
Serine/threonine-protein kinase Chk1

2

1

Small-scale

0.612

High

655804

TBG1
Tubulin gamma-1 chain

2

5

Small-scale

0.611

High

1055996

EVL
Ena/VASP-like protein

2

2

Small-scale

0.602

High

1055935

SNX32
Sorting nexin-32

2

0

High-throughput

0.602

High

1055978

RAD18
E3 ubiquitin-protein ligase RAD18

2

0

Small-scale

0.598

High

1055944

MCPH1
Microcephalin

2

1

Small-scale

0.595

High

1055964

FACD2
Fanconi anemia group D2 protein

2

1

Small-scale

0.595

High

1055980

PDS5B
Sister chromatid cohesion protein PDS5 homolog B

2

0

Small-scale

0.592

High

1055926

RFWD3
E3 ubiquitin-protein ligase RFWD3

1

1

Small-scale

0.586

High

1055977

TOPRS
E3 ubiquitin-protein ligase Topors

1

1

Small-scale

0.586

High

292903

RNH2A
Ribonuclease H2 subunit A

2

0

Small-scale

0.585

High

1055955

LRAT2
Protein LRATD2

1

1

High-throughput

0.582

High

1055965

NSD3
Histone-lysine N-methyltransferase NSD3

1

3

High-throughput

0.582

High

954681

SEM1
26S proteasome complex subunit SEM1

2

0

Small-scale

0.577

High

1055911

SPIDR
DNA repair-scaffolding protein

1

0

Small-scale

0.571

High

1055918

SWI5
DNA repair protein SWI5 homolog

2

0

Small-scale

0.569

High

1055989

BCCIP
BRCA2 and CDKN1A-interacting protein

2

0

Small-scale

0.569

High

1056002

AGO2
Protein argonaute-2

2

0

Small-scale

0.569

High

281150

DPOLQ
DNA polymerase theta

1

6

Small-scale

0.561

High

488002

DPOLA
DNA polymerase alpha catalytic subunit

1

1

Small-scale

0.561

High

664718

CCND1
G1/S-specific cyclin-D1

1

1

High-throughput

0.561

High

772489

IRS1
Insulin receptor substrate 1

1

2

Small-scale

0.561

High

886465

CTCF
Transcriptional repressor CTCF

1

1

Small-scale

0.561

High

1045208

TF65
Transcription factor p65

1

1

Small-scale

0.561

High

1055902

TP53B
TP53-binding protein 1

1

2

Small-scale

0.561

High

1055922

BRE1A
E3 ubiquitin-protein ligase BRE1A

1

6

Small-scale

0.561

High

1055956

EP400
E1A-binding protein p400

1

3

Small-scale

0.561

High

1055959

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

6

Small-scale

0.561

High

591611

H2AX
Histone H2AX

2

0

Small-scale

0.559

High

1055992

MO4L1
Mortality factor 4-like protein 1

2

0

Small-scale

0.559

High

539924

ARY2
Arylamine N-acetyltransferase 2

1

0

High-throughput

0.558

High

461394

HS90A
Heat shock protein HSP 90-alpha

1

4

High-throughput

0.541

High

1055901

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

3

High-throughput

0.541

High

1055916

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

1

High-throughput

0.541

High

1055940

SIR2
NAD-dependent protein deacetylase sirtuin-2

1

1

High-throughput

0.541

High

1055993

NXF1
Nuclear RNA export factor 1

1

1

High-throughput

0.541

High

1056004

JIP3
C-Jun-amino-terminal kinase-interacting protein 3

1

4

High-throughput

0.541

High

620316

NUCL
Nucleolin

1

0

Small-scale

0.537

High

704739

ERCC5
DNA excision repair protein ERCC-5

1

0

Small-scale

0.537

High

1056001

FBX5
F-box only protein 5

1

0

Small-scale

0.537

High

129724

CBX4
E3 SUMO-protein ligase CBX4

1

1

High-throughput

0.536

High

269181

HSF2B
Heat shock factor 2-binding protein

1

2

High-throughput

0.536

High

300746

KRT38
Keratin, type I cuticular Ha8

1

1

High-throughput

0.536

High

587633

DESP
Desmoplakin

1

2

High-throughput

0.536

High

776807

MYH11
Myosin-11

1

1

High-throughput

0.536

High

903064

DNA2
DNA replication ATP-dependent helicase/nuclease DNA2

1

1

High-throughput

0.536

High

955087

CDC42
Cell division control protein 42 homolog

1

1

High-throughput

0.536

High

1036709

DSG1
Desmoglein-1

1

1

High-throughput

0.536

High

1055928

MDEAS
Mitotic deacetylase-associated SANT domain protein

1

1

High-throughput

0.536

High

1055958

SPB12
Serpin B12

1

1

High-throughput

0.536

High

1055962

GCP2
Gamma-tubulin complex component 2

1

1

High-throughput

0.536

High

1055991

POLK
DNA polymerase kappa

1

1

High-throughput

0.536

High

1055900

R51A2
RAD51-associated protein 2

1

0

Small-scale

0.529

High

1055923

ARID2
AT-rich interactive domain-containing protein 2

1

0

Small-scale

0.529

High

1055929

MMS22
Protein MMS22-like

1

0

Small-scale

0.529

High

172730

XPO1
Exportin-1

1

5

Small-scale

0.527

High

191259

MSH4
MutS protein homolog 4

1

3

Small-scale

0.527

High

253760

UGDH
UDP-glucose 6-dehydrogenase

1

0

High-throughput

0.518

High

474631

VIME
Vimentin

1

0

High-throughput

0.518

High

539052

UMPS
Uridine 5'-monophosphate synthase

1

0

High-throughput

0.518

High

937577

CAD13
Cadherin-13

1

0

High-throughput

0.518

High

995001

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.518

High

1055948

NELFB
Negative elongation factor B

1

0

High-throughput

0.518

High

1056008

TIM13
Mitochondrial import inner membrane translocase subunit Tim13

1

2

High-throughput

0.515

High

1055982

PARI
PCNA-interacting partner

1

0

Small-scale

0.513

High

287912

MYCB2
E3 ubiquitin-protein ligase MYCBP2

1

0

High-throughput

0.513

High

370293

CYTA
Cystatin-A

1

0

High-throughput

0.513

High

503575

TFPT
TCF3 fusion partner

1

0

High-throughput

0.513

High

537028

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.513

High

593835

PP2BB
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

1

0

High-throughput

0.513

High

596062

H12
Histone H1.2

1

0

High-throughput

0.513

High

809603

RS19
Small ribosomal subunit protein eS19

1

0

High-throughput

0.513

High

858767

BRCC3
Lys-63-specific deubiquitinase BRCC36

1

0

Small-scale

0.513

High

977211

RS4X
Small ribosomal subunit protein eS4, X isoform

1

0

High-throughput

0.513

High

984728

RL31
Large ribosomal subunit protein eL31

1

0

High-throughput

0.513

High

996668

TBA1B
Tubulin alpha-1B chain

1

0

High-throughput

0.513

High

1005312

IGBP1
Immunoglobulin-binding protein 1

1

0

High-throughput

0.513

High

1030440

FABP5
Fatty acid-binding protein 5

1

0

High-throughput

0.513

High

1055909

LRP8
Low-density lipoprotein receptor-related protein 8

1

0

High-throughput

0.513

High

1055920

KHDC1
KH homology domain-containing protein 1

1

0

High-throughput

0.513

High

1055921

SGO1
Shugoshin 1

1

0

High-throughput

0.513

High

1055925

CDC73
Parafibromin

1

0

High-throughput

0.513

High

1055931

KI21A
Kinesin-like protein KIF21A

1

0

High-throughput

0.513

High

1055947

HASP
Serine/threonine-protein kinase haspin

1

0

High-throughput

0.513

High

1055954

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

High-throughput

0.513

High

1055957

HSFY1
Heat shock transcription factor, Y-linked

1

0

High-throughput

0.513

High

1055975

HM20A
High mobility group protein 20A

1

0

High-throughput

0.513

High

1055984

BABA2
BRISC and BRCA1-A complex member 2

1

0

Small-scale

0.513

High

1055987

UGGG1
UDP-glucose:glycoprotein glucosyltransferase 1

1

0

High-throughput

0.513

High

384402

CRYAA
Alpha-crystallin A chain

1

2

High-throughput

0.501

High

896512

VASP
Vasodilator-stimulated phosphoprotein

1

2

Small-scale

0.501

High

964241

SUMO2
Small ubiquitin-related modifier 2

1

2

Small-scale

0.501

High

1055936

SFR1
Swi5-dependent recombination DNA repair protein 1 homolog

1

1

Small-scale

0.501

High

1055942

ENAH
Protein enabled homolog

1

3

Small-scale

0.501

High

1055946

WDR48
WD repeat-containing protein 48

1

3

Small-scale

0.501

High

1055949

DDB2
DNA damage-binding protein 2

1

2

Small-scale

0.501

High

1055963

MND1
Meiotic nuclear division protein 1 homolog

1

5

Small-scale

0.501

High

1055981

FANCI
Fanconi anemia group I protein

1

2

Small-scale

0.501

High

404602

TFF1
Trefoil factor 1

1

1

High-throughput

0.494

High

1055934

ITIH5
Inter-alpha-trypsin inhibitor heavy chain H5

1

2

High-throughput

0.494

High

1055939

ZDH17
Palmitoyltransferase ZDHHC17

1

2

High-throughput

0.494

High

1056009

ST14
Suppressor of tumorigenicity 14 protein

1

1

High-throughput

0.494

High

833050

EIF2D
Eukaryotic translation initiation factor 2D

1

0

High-throughput

0.493

High

1056005

CAB39
Calcium-binding protein 39

1

0

High-throughput

0.493

High

1010599

DCD
Dermcidin

1

1

High-throughput

0.489

High

1056003

HECD1
E3 ubiquitin-protein ligase HECTD1

1

2

High-throughput

0.489

High

459559

PROF1
Profilin-1

1

0

Small-scale

0.486

High

768024

RFA3
Replication protein A 14 kDa subunit

1

0

Small-scale

0.486

High

297582

PIAS1
E3 SUMO-protein ligase PIAS1

1

3

Small-scale

0.481

High

1055979

FIRRM
FIGNL1-interacting regulator of recombination and mitosis

1

1

Small-scale

0.481

High

1056006

ARIP4
Helicase ARIP4

1

17

Small-scale

0.481

High

262066

NBN
Nibrin

1

0

Small-scale

0.480

High

540003

BCR
Breakpoint cluster region protein

1

0

Small-scale

0.480

High

997669

CSK21
Casein kinase II subunit alpha

1

0

Small-scale

0.480

High

1024522

VIGLN
Vigilin

1

0

Small-scale

0.479

High

117166

J9JIF5
CXXC-type zinc finger protein 4

1

1

High-throughput

0.479

High

157272

CTRO
Citron Rho-interacting kinase

1

1

Small-scale

0.479

High

187503

FANCA
Fanconi anemia group A protein

1

2

Small-scale

0.479

High

293603

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.479

High

315498

RECQ4
ATP-dependent DNA helicase Q4

1

14

Small-scale

0.479

High

386464

SPTA1
Spectrin alpha chain, erythrocytic 1

1

4

Small-scale

0.479

High

464931

SP1
Transcription factor Sp1

1

1

Small-scale

0.479

High

551001

PCNA
Proliferating cell nuclear antigen

1

1

Small-scale

0.479

High

567381

TCTP
Translationally-controlled tumor protein

1

1

High-throughput

0.479

High

611662

ERCC2
General transcription and DNA repair factor IIH helicase subunit XPD

1

3

Small-scale

0.479

High

637471

FLNA
Filamin-A

1

2

Small-scale

0.479

High

669878

MCM3
DNA replication licensing factor MCM3

1

2

Small-scale

0.479

High

702934

DPOD1
DNA polymerase delta catalytic subunit

1

1

Small-scale

0.479

High

714058

PML
Protein PML

1

2

Small-scale

0.479

High

754813

H2B1B
Histone H2B type 1-B

1

2

Small-scale

0.479

High

846592

MSH2
DNA mismatch repair protein Msh2

1

3

Small-scale

0.479

High

913306

MSH6
DNA mismatch repair protein Msh6

1

4

Small-scale

0.479

High

974366

SMD1
Small nuclear ribonucleoprotein Sm D1

1

1

Small-scale

0.479

High

974724

SMD3
Small nuclear ribonucleoprotein Sm D3

1

1

Small-scale

0.479

High

987572

GRB2
Growth factor receptor-bound protein 2

1

2

Small-scale

0.479

High

1055908

CUL1
Cullin-1

1

3

Small-scale

0.479

High

1055910

KEAP1
Kelch-like ECH-associated protein 1

1

1

Small-scale

0.479

High

1055932

DPOLN
DNA polymerase nu

1

1

Small-scale

0.479

High

1055937

ZGRF1
5'-3' DNA helicase ZGRF1

1

1

Small-scale

0.479

High

1055952

PF21A
PHD finger protein 21A

1

4

High-throughput

0.479

High

1055953

Q96BE0
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

1055971

BRD9
Bromodomain-containing protein 9

1

1

Small-scale

0.479

High

1055976

TRI36
E3 ubiquitin-protein ligase TRIM36

1

3

Small-scale

0.479

High

1055983

MCM9
DNA helicase MCM9

1

3

Small-scale

0.479

High

1055988

RTEL1
Regulator of telomere elongation helicase 1

1

3

High-throughput

0.479

High

1055990

HOP2
Homologous-pairing protein 2 homolog

1

3

Small-scale

0.479

High

1055997

XPO7
Exportin-7

1

4

High-throughput

0.479

High

1055998

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

1

Small-scale

0.479

High

1055999

RCOR1
REST corepressor 1

1

1

High-throughput

0.479

High

1056007

RN115
E3 ubiquitin-protein ligase RNF115

1

1

Small-scale

0.479

High

1055907

TDG
G/T mismatch-specific thymine DNA glycosylase

1

0

Small-scale

0.460

High

1056000

C8AP2
CASP8-associated protein 2

1

0

Small-scale

0.460

High

1056011

GMEB1
Glucocorticoid modulatory element-binding protein 1

1

0

Small-scale

0.460

High

246551

KDM1A
Lysine-specific histone demethylase 1A

1

0

High-throughput

0.458

High

279146

ULK1
Serine/threonine-protein kinase ULK1

1

0

Small-scale

0.458

High

376812

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

0

High-throughput

0.458

High

395976

ESR1
Estrogen receptor

1

0

Small-scale

0.458

High

574228

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

0

Small-scale

0.458

High

606677

CEBPB
CCAAT/enhancer-binding protein beta

1

0

Small-scale

0.458

High

613000

EGR1
Early growth response protein 1

1

0

High-throughput

0.458

High

941410

CTBP2
C-terminal-binding protein 2

1

0

High-throughput

0.458

High

946095

MLF1
Myeloid leukemia factor 1

1

0

High-throughput

0.458

High

951634

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

0

Small-scale

0.458

High

1022699

XIAP
E3 ubiquitin-protein ligase XIAP

1

0

Small-scale

0.458

High

1055904

ATM
Serine-protein kinase ATM

1

0

Small-scale

0.458

High

1055906

HDAC1
Histone deacetylase 1

1

0

High-throughput

0.458

High

1055915

PSF1
DNA replication complex GINS protein PSF1

1

0

Small-scale

0.458

High

1055930

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1055961

SOSB1
SOSS complex subunit B1

1

0

Small-scale

0.458

High

1055966

AICDA
Single-stranded DNA cytosine deaminase

1

0

Small-scale

0.458

High

1055967

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.458

High

1055969

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

0

Small-scale

0.458

High

1055970

DUS21
Dual specificity protein phosphatase 21

1

0

High-throughput

0.458

High

1055974

NMRL1
NmrA-like family domain-containing protein 1

1

0

High-throughput

0.458

High

1055985

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

Small-scale

0.458

High

952768

ACTB
Actin, cytoplasmic 1

1

1

Small-scale

0.457

High

1055950

RAD54
DNA repair and recombination protein RAD54-like

1

19

Small-scale

0.457

High

94368

D6RA96
Regulator of telomere elongation helicase 1

1

3

High-throughput

0.445

High

1055968

CXXC4
CXXC-type zinc finger protein 4

1

1

High-throughput

0.445

High

1055972

RMI1
RecQ-mediated genome instability protein 1

1

1

Small-scale

0.445

High

1055986

DONS
Protein downstream neighbor of Son

1

0

Small-scale

0.426

High

1055943

GG6L2
Golgin subfamily A member 6-like protein 2

1

3

High-throughput

0.407

High

1055903

IL24
Interleukin-24

1

0

High-throughput

0.304

High

1055917

CYTM
Cystatin-M

1

0

High-throughput

0.282

High

1055995

PCS1N
ProSAAS

1

0

High-throughput

0.282

High

133492

ACATN
Acetyl-coenzyme A transporter 1

1

0

High-throughput

0.279

Low

457963

TRY1
Serine protease 1

1

0

High-throughput

0.279

Low

900786

RAB5C
Ras-related protein Rab-5C

1

0

High-throughput

0.279

Low

1055919

T10IP
Testis-specific protein 10-interacting protein

1

0

High-throughput

0.279

Low

1055994

HMGX4
HMG domain-containing protein 4

1

0

High-throughput

0.279

Low

1055933

RN180
E3 ubiquitin-protein ligase RNF180

1

0

Small-scale

0.249

Low

1055973

Q9HAV2
Heat shock transcription factor 1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025