HitPredict

Interactor 1: FKBP (P20081)
FK506-binding protein 1 (FKBP) (12-kDa cytosolic FK506-binding protein) (FKBP-12) (Peptidyl-prolyl cis-trans isomerase) (PPIase) (EC 5.2.1.8) (Rapamycin-binding protein)
Gene: FPR1

Interactor 2: TOR1 (P35169)
Serine/threonine-protein kinase TOR1 (EC 2.7.11.1) (Dominant rapamycin resistance protein 1) (Phosphatidylinositol kinase homolog TOR1) (Target of rapamycin kinase 1)
Gene: TOR1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	1.00	0.838

Property	Details
Experiments	18812505, 12408816
Identification Methods	pull down, anti tag coimmunoprecipitation, affinity chromatography technology
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	FKBP_C~FRB_dom
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 114 Sc			1 2470
+	Sc
		690611 FKBP2_YEAST (5-113): 1.24e-49: 155: 50.91		TOR1_YEAST (1-2470): 0: 1922: 100.00
+	Sc
		589273 FKBP_YEAST (1-114): 1.68e-53: 164: 100.00		TOR2_YEAST (32-2470): 0: 1818: 67.45
+	Sc
		696534 FKBP4_YEAST (2-113): 1.05e-41: 142: 42.86		TOR2_YEAST (32-2470): 0: 1818: 67.45
+	Sp
		145530 FKBP_SCHPO (8-114): 5.56e-52: 160: 71.03		TOR1_SCHPO (77-2470): 0: 1662: 43.07
+	Hs
		787449 FKB1A_HUMAN (8-114): 5.84e-54: 165: 57.01		MTOR_HUMAN (72-2470): 0: 1605: 38.29
+	Hs
		787458 FKBP3_HUMAN (3-114): 5.21e-44: 144: 39.02		MTOR_HUMAN (72-2470): 0: 1605: 38.29
+	Hs
		1034841 FKBP5_HUMAN (6-114): 2.72e-16: 74.8: 27.93		ATR_HUMAN (292-2469): 0: 917: 16.27
+	Hs
		944225 FKBP5_HUMAN (6-114): 2.72e-16: 74.8: 27.93		PRKDC_HUMAN (481-2469): 0: 757: 14.21