HitPredict

Interactor 1: PRDX3 (P20108)
Thioredoxin-dependent peroxide reductase, mitochondrial (EC 1.11.1.24) (Antioxidant protein 1) (AOP-1) (PRX III) (Perioredoxin-3) (Protein MER5) (Thioredoxin-dependent peroxiredoxin 3)
Gene: PRDX3

Interactor 2: THIOM (P97493)
Thioredoxin, mitochondrial (MTRX) (Mt-Trx) (Thioredoxin-2)
Gene: Txn2

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	31018154
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	1-cysPrx_C~Thioredoxin, AhpC-TSA~Thioredoxin
Common GO terms	GO:0005739 - mitochondrion GO:0006979 - response to oxidative stress GO:0045454 - cell redox homeostasis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 257 Mm			1 166
+	Mm
		956730 PRDX2_MOUSE (60-256): 9.22e-105: 303: 62.94		THIOM_MOUSE (1-166): 1.73e-53: 168: 100.00
+	Mm
		139927 PRDX4_MOUSE (40-256): 2.38e-101: 297: 58.53		THIOM_MOUSE (1-166): 1.73e-53: 168: 100.00
+	Mm
		727682 PRDX1_MOUSE (60-254): 1.55e-100: 293: 61.74		THIOM_MOUSE (1-166): 1.73e-53: 168: 100.00
+	Hs
		531737 PRDX3_HUMAN (1-257): 6.51e-119: 341: 85.60		PDIA4_HUMAN (60-165): 1.07e-28: 112: 27.52
+	Hs
		495475 PRDX2_HUMAN (60-256): 1.28e-104: 303: 63.45		THIO_HUMAN (61-165): 1.71e-36: 123: 34.91
+	Hs
		423216 PRDX4_HUMAN (40-256): 8.43e-101: 296: 58.07		PDIA1_HUMAN (52-166): 3.4e-34: 127: 27.50
+	Os
		1150818 BAS1_ORYSJ (1-255): 3.36e-102: 299: 45.98		TRXX_ORYSJ (1-165): 1.48e-35: 123: 22.99
+	Hs
		1026686 PRDX4_HUMAN (40-256): 8.43e-101: 296: 58.07		PDIA6_HUMAN (62-165): 2.6e-32: 121: 23.81
+	Hs
		495510 PRDX1_HUMAN (60-254): 1.02e-100: 293: 63.27		THIO_HUMAN (61-165): 1.71e-36: 123: 34.91
+	At
		1227668 BAS1B_ARATH (17-255): 1.39e-98: 290: 47.11		TRXX_ARATH (2-165): 2.67e-36: 125: 23.53
+	So
		188731 BAS1_SPIOL (1-255): 5.67e-94: 278: 43.45		TRXM_SPIOL (14-165): 2.43e-39: 133: 23.03
+	Hs
		671804 PRDX4_HUMAN (40-256): 8.43e-101: 296: 58.07		PDIA3_HUMAN (49-163): 5.5e-30: 115: 23.53
+	Hs
		531815 PRDX4_HUMAN (40-256): 8.43e-101: 296: 58.07		PDIA4_HUMAN (60-165): 1.07e-28: 112: 27.52
+	Rn
		751965 PRDX4_RAT (40-256): 3.6e-101: 297: 58.07		PDIA4_RAT (16-165): 5.3e-28: 110: 23.23
+	At
		1227667 BAS1A_ARATH (58-255): 1.69e-93: 277: 54.00		TRXX_ARATH (2-165): 2.67e-36: 125: 23.53
+	Ss
		852832 Y755_SYNY3 (61-257): 1.11e-91: 270: 54.55		THIO_SYNY3 (59-165): 8.35e-39: 129: 31.78
+	Sc
		611720 TSA1_YEAST (62-257): 5.35e-90: 266: 58.16		TRX2_YEAST (61-154): 7.37e-36: 122: 31.92
+	Ss
		852848 Y755_SYNY3 (61-257): 1.11e-91: 270: 54.55		THIO1_SYNY3 (65-151): 3.22e-34: 117: 31.03
+	Sc
		606199 TSA1_YEAST (62-257): 5.35e-90: 266: 58.16		TRX1_YEAST (61-154): 2.56e-35: 120: 37.23
+	Sc
		606220 TSA2_YEAST (62-256): 2.52e-86: 256: 56.41		TRX1_YEAST (61-154): 2.56e-35: 120: 37.23