HitPredict

Interactor 1: CD33 (P20138)
Myeloid cell surface antigen CD33 (Sialic acid-binding Ig-like lectin 3) (Siglec-3) (gp67) (CD antigen CD33)
Gene: CD33

Interactor 2: PTN11 (Q06124)
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
Gene: PTPN11

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.708

Property	Details
Experiments	10206955, 17008544, 10887109, 17947393
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 364 Hs			1 593
+	Hs
		589559 CD33_HUMAN (11-364): 6.09e-86: 265: 100.00		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Hs
		986050 SLAF5_HUMAN (4-362): 3.5e-45: 160: 19.11		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Mm
		719313 SIG10_MOUSE (24-311): 2.55e-22: 100: 14.15		PTN11_MOUSE (1-593): 0: 580: 99.49
+	Hs
		986013 SIG10_HUMAN (74-308): 4.12e-20: 93.8: 12.96		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		545101 PVR_HUMAN (19-246): 7.82e-18: 86: 19.92		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		986062 SIGL9_HUMAN (109-362): 2e-17: 85.3: 21.99		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		177596 SIGL5_HUMAN (22-363): 3.41e-17: 84.9: 18.73		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		986060 SIGL7_HUMAN (109-362): 1.07e-13: 73.7: 20.14		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		986018 SIG11_HUMAN (27-362): 9.67e-12: 68.3: 20.61		PTN11_HUMAN (1-593): 0: 581: 100.00
+	Hs
		665940 SIG10_HUMAN (74-308): 4.12e-20: 93.8: 12.96		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Hs
		590601 CD22_HUMAN (10-254): 1.34e-18: 89.1: 16.73		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Mm
		665976 CD22_MOUSE (4-254): 3.42e-18: 88: 15.02		PTN6_MOUSE (6-583): 0: 530: 55.94
+	Hs
		665971 SIGL9_HUMAN (109-362): 2e-17: 85.3: 21.99		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Hs
		177594 SIGL5_HUMAN (22-363): 3.41e-17: 84.9: 18.73		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Hs
		665970 SIGL7_HUMAN (109-362): 1.07e-13: 73.7: 20.14		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Hs
		665942 SIG11_HUMAN (27-362): 9.67e-12: 68.3: 20.61		PTN6_HUMAN (6-593): 0: 531: 55.27
+	Hs
		573657 CXAR_HUMAN (4-354): 1.35e-50: 174: 14.80		PTN1_HUMAN (232-541): 4.38e-110: 338: 31.63
+	Dm
		1308480 Q9BN17_DROME (30-320): 8.46e-21: 96.1: 12.13		Q9W4F5_DROME (191-560): 1.41e-112: 371: 29.38
+	Hs
		441175 CD22_HUMAN (10-254): 1.34e-18: 89.1: 16.73		PTPRC_HUMAN (33-579): 2.25e-85: 291: 18.29
+	Hs
		1069952 PXDN_HUMAN (140-356): 1.35e-29: 122: 9.79		PTPRK_HUMAN (36-524): 5.17e-72: 254: 18.94