HitPredict

Interactor 1: CCNA2 (P20248)
Cyclin-A2 (Cyclin-A) (Cyclin A)
Gene: CCNA2

Interactor 2: CDK2 (P24941)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)
Gene: CDK2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 1.00 0.996

The method score is based on:

Property Details
Experiments 19483727, 11983168, 21241890, 25669885, 26496610, 12853968, 22231403, 33961781, 33422522, 20733051, 9724724, 9716181, 8475101, 11940657, 18471975, 7630397, 9660939, 8662825, 8463339, 24302728 and 31 others

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Identification Methods affinity chromatography technology, pull down, x-ray crystallography, enzymatic study, coimmunoprecipitation, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, tandem affinity purification
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Cyclin_C~Pkinase, Cyclin_N~Pkinase
Common GO terms GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0000307 - cyclin-dependent protein kinase holoenzyme complex
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
and 11 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 432
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024