HitPredict

Interactor 1: TNR1B (P20333)
Tumor necrosis factor receptor superfamily member 1B (Tumor necrosis factor receptor 2) (TNF-R2) (Tumor necrosis factor receptor type II) (TNF-RII) (TNFR-II) (p75) (p80 TNF-alpha receptor) (CD antigen CD120b) (Etanercept) [Cleaved into: Tumor necrosis factor receptor superfamily member 1b, membrane form; Tumor necrosis factor-binding protein 2 (TBP-2) (TBPII)]
Gene: TNFRSF1B

Interactor 2: TRAF6 (Q9Y4K3)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	9915784
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0033209 - tumor necrosis factor-mediated signaling pathway GO:0048471 - perinuclear region of cytoplasm GO:0071222 - cellular response to lipopolysaccharide
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 461 Hs			1 522
+	Hs
		591317 TNR1B_HUMAN (1-461): 5.19e-141: 413: 100.00		TRAF2_HUMAN (40-500): 7.2e-101: 314: 25.85
+	Hs
		591320 TNR1B_HUMAN (1-461): 5.19e-141: 413: 100.00		TRAF3_HUMAN (19-501): 9.91e-86: 277: 22.18
+	Hs
		591319 TNR1B_HUMAN (1-461): 5.19e-141: 413: 100.00		TRAF1_HUMAN (50-501): 5.58e-64: 216: 19.40
+	Hs
		436651 TNR16_HUMAN (34-313): 6.31e-47: 169: 21.18		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Rn
		78177 TNR16_RAT (34-313): 5.24e-47: 169: 20.49		TRAF6_RAT (1-522): 7.85e-142: 421: 86.42
+	Hs
		301610 TNR1B_HUMAN (1-461): 5.19e-141: 413: 100.00		TRI37_HUMAN (56-501): 7.36e-43: 165: 13.89
+	Hs
		436618 TNR16_HUMAN (34-313): 6.31e-47: 169: 21.18		TRAF2_HUMAN (40-500): 7.2e-101: 314: 25.85
+	Hs
		738659 TNR3_HUMAN (2-216): 5.3e-47: 169: 30.94		TRAF2_HUMAN (40-500): 7.2e-101: 314: 25.85
+	Rn
		78206 TNR16_RAT (34-313): 5.24e-47: 169: 20.49		B5DFH7_RAT (40-500): 4.24e-100: 312: 25.81
+	Hs
		436641 TNR16_HUMAN (34-313): 6.31e-47: 169: 21.18		TRAF4_HUMAN (54-500): 6.36e-91: 287: 26.11
+	Hs
		738694 TNR3_HUMAN (2-216): 5.3e-47: 169: 30.94		TRAF4_HUMAN (54-500): 6.36e-91: 287: 26.11
+	Hs
		129526 TNR16_HUMAN (34-313): 6.31e-47: 169: 21.18		TRAF5_HUMAN (43-500): 4.95e-87: 280: 25.23
+	Hs
		129536 TNR3_HUMAN (2-216): 5.3e-47: 169: 30.94		TRAF5_HUMAN (43-500): 4.95e-87: 280: 25.23
+	Hs
		436620 TNR16_HUMAN (34-313): 6.31e-47: 169: 21.18		TRAF3_HUMAN (19-501): 9.91e-86: 277: 22.18
+	Hs
		738661 TNR3_HUMAN (2-216): 5.3e-47: 169: 30.94		TRAF3_HUMAN (19-501): 9.91e-86: 277: 22.18
+	Hs
		436619 TNR16_HUMAN (34-313): 6.31e-47: 169: 21.18		TRAF1_HUMAN (50-501): 5.58e-64: 216: 19.40
+	Hs
		738660 TNR3_HUMAN (2-216): 5.3e-47: 169: 30.94		TRAF1_HUMAN (50-501): 5.58e-64: 216: 19.40
+	Hs
		301556 TNR16_HUMAN (34-313): 6.31e-47: 169: 21.18		TRI37_HUMAN (56-501): 7.36e-43: 165: 13.89
+	Hs
		301657 TNR3_HUMAN (2-216): 5.3e-47: 169: 30.94		TRI37_HUMAN (56-501): 7.36e-43: 165: 13.89
+	Hs
		738686 TNR3_HUMAN (2-216): 5.3e-47: 169: 30.94		RN166_HUMAN (61-222): 7.37e-16: 79.1: 22.94