Protein: ITB4
Integrin beta-4 (GP150) (CD antigen CD104)

Gene: ITB4, ITGB4
Organism: Homo sapiens
Interactions: 113
UniProt ID: P16144

Gene Ontology (top 5):
GO:0001664 - G protein-coupled receptor binding
GO:0005178 - integrin binding
GO:0005604 - basement membrane
GO:0005730 - nucleolus
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

592620

ITA6
Integrin alpha-6

3

20

Small-scale

0.847

High

362709

EGFR
Epidermal growth factor receptor

2

20

Small-scale

0.789

High

592704

TRIM1
Probable E3 ubiquitin-protein ligase MID2

2

20

High-throughput

0.783

High

592652

PLEC
Plectin

1

19

Small-scale

0.692

High

592627

BAG6
Large proline-rich protein BAG6

1

4

High-throughput

0.691

High

592648

ILK
Scaffold protein ILK

1

6

High-throughput

0.691

High

592679

CLC2B
C-type lectin domain family 2 member B

1

16

High-throughput

0.691

High

592687

ERBIN
Erbin

1

1

Small-scale

0.680

High

592644

FAK1
Focal adhesion kinase 1

1

20

Small-scale

0.665

High

592698

SIRPD
Signal-regulatory protein delta

1

0

High-throughput

0.656

High

592623

SHC1
SHC-transforming protein 1

1

19

Small-scale

0.647

High

592614

LOX12
Polyunsaturated fatty acid lipoxygenase ALOX12

2

1

Small-scale

0.632

High

563133

CFTR
Cystic fibrosis transmembrane conductance regulator

2

3

High-throughput

0.628

High

592642

DYST
Dystonin

1

20

Small-scale

0.621

High

592631

NEK4
Serine/threonine-protein kinase Nek4

1

9

High-throughput

0.618

High

592616

FLNA
Filamin-A

1

20

Small-scale

0.618

High

592618

CBL
E3 ubiquitin-protein ligase CBL

1

8

High-throughput

0.618

High

592622

ITA3
Integrin alpha-3

1

20

Small-scale

0.618

High

592629

CD151
CD151 antigen

2

20

Small-scale

0.611

High

70107

CRTP1
Cysteine-rich tail protein 1

2

2

High-throughput

0.606

High

592619

TGM1
Protein-glutamine gamma-glutamyltransferase K

2

3

High-throughput

0.606

High

592653

K1H1
Keratin, type I cuticular Ha1

2

8

High-throughput

0.606

High

592654

TRIP6
Thyroid receptor-interacting protein 6

2

7

High-throughput

0.606

High

592702

PLS4
Phospholipid scramblase 4

2

1

High-throughput

0.606

High

516960

NT2NC
Notch homolog 2 N-terminal-like protein C

1

10

High-throughput

0.594

High

592708

COHA1
Collagen alpha-1(XVII) chain

2

4

Small-scale

0.586

High

592656

ECM1
Extracellular matrix protein 1

2

0

High-throughput

0.580

High

592664

KPRP
Keratinocyte proline-rich protein

2

0

High-throughput

0.580

High

484039

PGFRB
Platelet-derived growth factor receptor beta

1

16

High-throughput

0.575

High

592671

NT2NA
Notch homolog 2 N-terminal-like protein A

1

10

High-throughput

0.555

High

561206

MYF5
Myogenic factor 5

2

2

High-throughput

0.553

High

592630

HXA1
Homeobox protein Hox-A1

2

1

High-throughput

0.553

High

592636

KR107
Keratin-associated protein 10-7

2

17

High-throughput

0.553

High

592637

KR108
Keratin-associated protein 10-8

2

19

High-throughput

0.553

High

592638

KR109
Keratin-associated protein 10-9

2

18

High-throughput

0.553

High

592645

KRA11
Keratin-associated protein 1-1

2

19

High-throughput

0.553

High

592663

MTUS2
Microtubule-associated tumor suppressor candidate 2

2

10

High-throughput

0.553

High

592666

K1C40
Keratin, type I cytoskeletal 40

2

8

High-throughput

0.553

High

592670

ATL4
ADAMTS-like protein 4

2

1

High-throughput

0.553

High

592672

KRA13
Keratin-associated protein 1-3

2

19

High-throughput

0.553

High

592680

APBP2
Amyloid protein-binding protein 2

2

3

High-throughput

0.553

High

592693

KRA93
Keratin-associated protein 9-3

2

19

High-throughput

0.553

High

592694

KRA92
Keratin-associated protein 9-2

2

19

High-throughput

0.553

High

592695

KRA42
Keratin-associated protein 4-2

2

19

High-throughput

0.553

High

592696

KRA31
Keratin-associated protein 3-1

2

1

High-throughput

0.553

High

592649

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

10

High-throughput

0.553

High

269901

SDC3
Syndecan-3

1

13

Small-scale

0.552

High

592615

SDC1
Syndecan-1

1

7

Small-scale

0.552

High

592624

KAIN
Kallistatin

1

0

High-throughput

0.546

High

341283

ECEL1
Endothelin-converting enzyme-like 1

1

1

High-throughput

0.536

High

592633

TERA
Transitional endoplasmic reticulum ATPase

1

2

High-throughput

0.536

High

592706

ADA30
Disintegrin and metalloproteinase domain-containing protein 30

1

14

High-throughput

0.536

High

592707

MYH13
Myosin-13

1

6

High-throughput

0.536

High

592640

SMAD3
Mothers against decapentaplegic homolog 3

1

2

Small-scale

0.515

High

592655

SMAD2
Mothers against decapentaplegic homolog 2

1

2

Small-scale

0.515

High

592684

ARRD3
Arrestin domain-containing protein 3

1

5

Small-scale

0.515

High

592665

A16L1
Autophagy-related protein 16-1

1

4

High-throughput

0.514

High

592641

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

0

High-throughput

0.513

High

592683

P2R3C
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma

1

0

High-throughput

0.513

High

592634

IF6
Eukaryotic translation initiation factor 6

1

0

Small-scale

0.504

High

592646

SRBP2
Sterol regulatory element-binding protein 2

1

6

High-throughput

0.494

High

583430

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

3

High-throughput

0.489

High

592651

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

6

High-throughput

0.489

High

592662

GXLT1
Glucoside xylosyltransferase 1

1

1

High-throughput

0.489

High

592667

KLC3
Kinesin light chain 3

1

3

High-throughput

0.489

High

592668

BRID5
BRICHOS domain-containing protein 5

1

2

High-throughput

0.489

High

592676

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

5

High-throughput

0.489

High

592685

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

1

4

High-throughput

0.489

High

592686

MYO19
Unconventional myosin-XIX

1

9

High-throughput

0.489

High

592699

CST11
Cystatin-11

1

4

High-throughput

0.489

High

592632

ATX1
Ataxin-1

1

0

High-throughput

0.486

High

592625

SDC2
Syndecan-2

1

6

Small-scale

0.481

High

217793

TGON2
Trans-Golgi network integral membrane protein 2

1

14

High-throughput

0.479

High

326432

S1PR2
Sphingosine 1-phosphate receptor 2

1

8

Small-scale

0.479

High

555330

SKI
Ski oncogene

1

2

Small-scale

0.479

High

592613

LEG3
Galectin-3

1

20

Small-scale

0.479

High

592617

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

3

Small-scale

0.479

High

592626

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

1

10

High-throughput

0.479

High

592628

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.479

High

592639

X3CL1
Fractalkine

1

3

Small-scale

0.479

High

592681

LPAR1
Lysophosphatidic acid receptor 1

1

6

Small-scale

0.479

High

592688

S1PR3
Sphingosine 1-phosphate receptor 3

1

6

Small-scale

0.479

High

592697

KRA24
Keratin-associated protein 2-4

1

19

High-throughput

0.470

High

592643

FOLH1
Glutamate carboxypeptidase 2

1

0

Small-scale

0.458

High

592650

ENPP2
Autotaxin

1

0

Small-scale

0.458

High

480683

LEG1
Galectin-1

1

20

High-throughput

0.445

High

592673

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

1

High-throughput

0.445

High

592674

LYPD1
Ly6/PLAUR domain-containing protein 1

1

1

High-throughput

0.445

High

475

NBPFJ
NBPF family member NBPF19

1

10

High-throughput

0.439

High

505300

KRA23
Keratin-associated protein 2-3

1

19

High-throughput

0.439

High

592692

KRA98
Keratin-associated protein 9-8

1

19

High-throughput

0.439

High

592701

ANLN
Anillin

1

1

High-throughput

0.437

High

592703

SE1L1
Protein sel-1 homolog 1

1

12

Small-scale

0.437

High

592682

AP2C
Transcription factor AP-2 gamma

1

2

High-throughput

0.417

High

170649

CLGN
Calmegin

1

7

High-throughput

0.407

High

592621

CMA1
Chymase

1

7

High-throughput

0.407

High

592647

CTBP1
C-terminal-binding protein 1

1

3

High-throughput

0.407

High

592677

PATE1
Prostate and testis expressed protein 1

1

1

High-throughput

0.407

High

592690

SIA7E
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5

1

3

High-throughput

0.407

High

592709

KLK5
Kallikrein-5

1

7

High-throughput

0.407

High

592635

KR123
Keratin-associated protein 12-3

2

0

High-throughput

0.316

High

592657

OBF1
POU domain class 2-associating factor 1

2

0

High-throughput

0.316

High

592659

KRA62
Keratin-associated protein 6-2

2

0

High-throughput

0.316

High

592661

KR151
Keratin-associated protein 15-1

2

0

High-throughput

0.316

High

592689

MDFI
MyoD family inhibitor

2

0

High-throughput

0.316

High

592691

KR171
Keratin-associated protein 17-1

2

0

High-throughput

0.316

High

592705

DKKL1
Dickkopf-like protein 1

2

0

High-throughput

0.313

High

592658

TAZ
Tafazzin

1

0

High-throughput

0.279

Low

592675

FA24B
Protein FAM24B

1

0

High-throughput

0.279

Low

592700

GEMI7
Gem-associated protein 7

1

0

High-throughput

0.279

Low

592660

KRA63
Keratin-associated protein 6-3

1

0

High-throughput

0.268

Low

592669

LRC31
Leucine-rich repeat-containing protein 31

1

0

High-throughput

0.249

Low

592678

DNS2B
Deoxyribonuclease-2-beta

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025