HitPredict

Interactor 1: RAB6A (P20340)
Ras-related protein Rab-6A (Rab-6)
Gene: RAB6A

Interactor 2: OCRL (Q01968)
Inositol polyphosphate 5-phosphatase OCRL (EC 3.1.3.36) (EC 3.1.3.56) (Inositol polyphosphate 5-phosphatase OCRL-1) (OCRL-1) (Lowe oculocerebrorenal syndrome protein) (Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase) (EC 3.1.3.86)
Gene: OCRL

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.973

Property	Details
Experiments	16902405, 28514442, 27173435, 32203420, 33961781, 25107275, unassigned2213, 21378754
Identification Methods	pull down, affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation, fluorescence polarization spectroscopy, two hybrid, molecular sieving, enzyme linked immunosorbent assay
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Ras~RhoGAP
Common GO terms	GO:0005802 - trans-Golgi network GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016020 - membrane
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 208 Hs			1 901
+	Hs
		918850 RAB1A_HUMAN (1-207): 2.16e-92: 270: 35.27		OCRL_HUMAN (1-901): 0: 1075: 100.00
+	Hs
		592207 RAB5A_HUMAN (3-207): 1.63e-90: 266: 40.00		OCRL_HUMAN (1-901): 0: 1075: 100.00
+	Hs
		844489 RAB5C_HUMAN (3-207): 7.83e-91: 266: 39.51		OCRL_HUMAN (1-901): 0: 1075: 100.00
+	Hs
		968226 RAB6B_HUMAN (1-208): 5.58e-90: 264: 90.87		OCRL_HUMAN (1-901): 0: 1075: 100.00
+	Hs
		968218 RAB1B_HUMAN (9-206): 1.18e-89: 263: 35.86		OCRL_HUMAN (1-901): 0: 1075: 100.00
+	Hs
		914016 RB11A_HUMAN (3-206): 1.19e-86: 256: 29.58		OCRL_HUMAN (1-901): 0: 1075: 100.00
+	Hs
		968196 RAB1C_HUMAN (10-206): 3.08e-86: 254: 35.53		OCRL_HUMAN (1-901): 0: 1075: 100.00
+	Rn
		1157320 RAB1A_RAT (1-207): 2.16e-92: 270: 35.27		R9PXS2_RAT (14-901): 0: 1038: 93.81
+	Rn
		112176 RAB5A_RAT (3-207): 3.99e-90: 265: 40.00		R9PXS2_RAT (14-901): 0: 1038: 93.81
+	Rn
		1376736 RAB6A_RAT (1-208): 2.21e-89: 262: 99.04		R9PXS2_RAT (14-901): 0: 1038: 93.81
+	Hs
		895348 RAB5B_HUMAN (13-178): 1.33e-47: 157: 45.18		OCRL_HUMAN (1-901): 0: 1075: 100.00
+	Hs
		968138 RAB31_HUMAN (11-199): 3.82e-45: 150: 36.51		OCRL_HUMAN (1-901): 0: 1075: 100.00
+	Hs
		592125 RAB5A_HUMAN (3-207): 1.63e-90: 266: 40.00		I5P2_HUMAN (143-897): 0: 719: 50.27
+	Dm
		185463 O18332_DROME (1-207): 5.56e-90: 264: 34.78		O46094_DROME (209-900): 1.12e-177: 537: 33.15
+	Dm
		185584 RAB6_DROME (1-208): 1.2e-83: 248: 87.56		O46094_DROME (209-900): 1.12e-177: 537: 33.15
+	Dm
		220979 RAB5_DROME (13-175): 1.27e-47: 157: 44.79		O46094_DROME (209-900): 1.12e-177: 537: 33.15
+	Dm
		185619 RAB6_DROME (1-208): 1.2e-83: 248: 87.56		Q95R90_DROME (380-900): 5.7e-116: 365: 32.27