Protein: BIRC5
Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor 4) (Apoptosis inhibitor survivin)

Gene: BIRC5
Organism: Homo sapiens
Interactions: 115
UniProt ID: O15392

Gene Ontology (top 5):
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0000228 - nuclear chromosome
GO:0000278 - mitotic cell cycle
GO:0000281 - mitotic cytokinesis
GO:0000775 - chromosome, centromeric region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

177628

BIRC5
Baculoviral IAP repeat-containing protein 5

9

18

Small-scale

0.975

High

177726

DBLOH
Diablo IAP-binding mitochondrial protein

6

11

Small-scale

0.953

High

177671

XIAP
E3 ubiquitin-protein ligase XIAP

4

18

Small-scale

0.903

High

177678

BIRC2
Baculoviral IAP repeat-containing protein 2

3

18

Small-scale

0.878

High

177658

CASP3
Caspase-3

3

20

Small-scale

0.853

High

177663

CASP7
Caspase-7

2

20

Small-scale

0.799

High

177693

BOREA
Borealin

16

1

Small-scale

0.767

High

177714

AURKB
Aurora kinase B

17

9

Small-scale

0.766

High

177724

INCE
Inner centromere protein

10

9

Small-scale

0.759

High

177664

CASP9
Caspase-9

2

20

Small-scale

0.754

High

177731

FBXL7
F-box/LRR-repeat protein 7

3

0

Small-scale

0.654

High

177677

BIRC3
Baculoviral IAP repeat-containing protein 3

1

18

Small-scale

0.647

High

50853

SRCRL
Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D

2

4

High-throughput

0.628

High

177631

MED14
Mediator of RNA polymerase II transcription subunit 14

2

3

High-throughput

0.628

High

177732

ASC
Apoptosis-associated speck-like protein containing a CARD

2

1

High-throughput

0.628

High

177734

AURKC
Aurora kinase C

2

9

Small-scale

0.626

High

177629

LTOR5
Ragulator complex protein LAMTOR5

3

0

Small-scale

0.625

High

160260

AURKA
Aurora kinase A

1

9

Small-scale

0.612

High

177635

MED6
Mediator of RNA polymerase II transcription subunit 6

2

0

High-throughput

0.602

High

177679

MED21
Mediator of RNA polymerase II transcription subunit 21

2

0

High-throughput

0.602

High

177686

MED22
Mediator of RNA polymerase II transcription subunit 22

2

0

High-throughput

0.602

High

177713

MED8
Mediator of RNA polymerase II transcription subunit 8

2

0

High-throughput

0.602

High

177715

MED30
Mediator of RNA polymerase II transcription subunit 30

2

0

High-throughput

0.602

High

177718

MED10
Mediator of RNA polymerase II transcription subunit 10

2

0

High-throughput

0.602

High

177719

MED18
Mediator of RNA polymerase II transcription subunit 18

2

0

High-throughput

0.602

High

177722

MED20
Mediator of RNA polymerase II transcription subunit 20

2

0

High-throughput

0.602

High

177727

MED17
Mediator of RNA polymerase II transcription subunit 17

2

0

High-throughput

0.602

High

177728

MED29
Mediator of RNA polymerase II transcription subunit 29

2

0

High-throughput

0.602

High

177735

MED31
Mediator of RNA polymerase II transcription subunit 31

2

0

High-throughput

0.602

High

177683

BECN1
Beclin-1

2

2

Small-scale

0.601

High

177712

STALP
AMSH-like protease

2

0

Small-scale

0.598

High

177667

RAN
GTP-binding nuclear protein Ran

1

7

Small-scale

0.589

High

177697

GA2L3
GAS2-like protein 3

1

3

Small-scale

0.586

High

177644

CDK1
Cyclin-dependent kinase 1

2

4

Small-scale

0.584

High

177645

HS90A
Heat shock protein HSP 90-alpha

2

4

Small-scale

0.584

High

177648

XRCC6
X-ray repair cross-complementing protein 6

2

2

Small-scale

0.584

High

177649

H2AX
Histone H2AX

2

4

Small-scale

0.584

High

177669

PRKDC
DNA-dependent protein kinase catalytic subunit

2

3

Small-scale

0.584

High

177684

MDC1
Mediator of DNA damage checkpoint protein 1

2

8

Small-scale

0.584

High

177688

CC85B
Coiled-coil domain-containing protein 85B

2

0

High-throughput

0.580

High

162215

XPO1
Exportin-1

1

5

Small-scale

0.578

High

177641

HBAZ
Hemoglobin subunit zeta

2

1

High-throughput

0.574

High

177707

C102A
Coiled-coil domain-containing protein 102A

2

3

High-throughput

0.574

High

177654

MYH10
Myosin-10

1

2

Small-scale

0.561

High

177633

EVI5
Ecotropic viral integration site 5 protein homolog

1

0

Small-scale

0.537

High

177640

CYTN
Cystatin-SN

1

1

High-throughput

0.536

High

177651

S100P
Protein S100-P

1

4

High-throughput

0.536

High

177687

MED1
Mediator of RNA polymerase II transcription subunit 1

1

2

High-throughput

0.536

High

177655

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

3

High-throughput

0.515

High

177689

USF2
Upstream stimulatory factor 2

1

2

High-throughput

0.515

High

177643

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.515

High

177646

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

2

High-throughput

0.515

High

177659

HD
Huntingtin

1

1

High-throughput

0.515

High

177676

TADBP
TAR DNA-binding protein 43

1

5

High-throughput

0.515

High

177682

DCTN1
Dynactin subunit 1

1

6

High-throughput

0.515

High

177710

OPTN
Optineurin

1

12

High-throughput

0.515

High

177720

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

5

High-throughput

0.515

High

177723

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.513

High

174453

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

7

High-throughput

0.501

High

177695

H32
Histone H3.2

1

6

Small-scale

0.501

High

177657

SYUA
Alpha-synuclein

1

0

High-throughput

0.493

High

177696

PEX26
Peroxisome assembly protein 26

1

0

High-throughput

0.493

High

177701

GDAP1
Ganglioside-induced differentiation-associated protein 1

1

0

High-throughput

0.493

High

177703

APBB2
Amyloid beta precursor protein binding family B member 2

1

0

High-throughput

0.493

High

177652

S10A2
Protein S100-A2

1

4

High-throughput

0.489

High

177694

ATLA3
Atlastin-3

1

1

High-throughput

0.489

High

118646

AIP
AH receptor-interacting protein

1

1

Small-scale

0.479

High

171467

UBD
Ubiquitin D

1

10

Small-scale

0.479

High

177630

PRC1
Protein regulator of cytokinesis 1

1

1

High-throughput

0.479

High

177632

PRKN
E3 ubiquitin-protein ligase parkin

1

13

Small-scale

0.479

High

177638

UBP19
Ubiquitin carboxyl-terminal hydrolase 19

1

15

Small-scale

0.479

High

177639

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

5

High-throughput

0.479

High

177642

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

5

High-throughput

0.479

High

177647

CDK4
Cyclin-dependent kinase 4

1

6

Small-scale

0.479

High

177650

CDK2
Cyclin-dependent kinase 2

1

4

Small-scale

0.479

High

177653

HSP74
Heat shock 70 kDa protein 4

1

6

Small-scale

0.479

High

177660

CBX5
Chromobox protein homolog 5

1

1

High-throughput

0.479

High

177665

CTBP2
C-terminal-binding protein 2

1

6

High-throughput

0.479

High

177666

H2B1C
Histone H2B type 1-C/E/F/G/I

1

1

High-throughput

0.479

High

177668

H31
Histone H3.1

1

6

High-throughput

0.479

High

177670

H33
Histone H3.3

1

6

High-throughput

0.479

High

177672

KIF23
Kinesin-like protein KIF23

1

3

High-throughput

0.479

High

177674

TP53B
TP53-binding protein 1

1

5

Small-scale

0.479

High

177675

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

3

Small-scale

0.479

High

177680

CUL4A
Cullin-4A

1

4

High-throughput

0.479

High

177681

CUL4B
Cullin-4B

1

4

High-throughput

0.479

High

177685

KIF14
Kinesin-like protein KIF14

1

4

High-throughput

0.479

High

177690

RB11B
Ras-related protein Rab-11B

1

5

Small-scale

0.479

High

177698

CUL9
Cullin-9

1

6

Small-scale

0.479

High

177699

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

1

High-throughput

0.479

High

177700

UBP38
Ubiquitin carboxyl-terminal hydrolase 38

1

20

Small-scale

0.479

High

177704

UFD1
Ubiquitin recognition factor in ER-associated degradation protein 1

1

1

Small-scale

0.479

High

177705

CSN5
COP9 signalosome complex subunit 5

1

4

Small-scale

0.479

High

177706

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

7

Small-scale

0.479

High

177709

CHM4C
Charged multivesicular body protein 4c

1

2

High-throughput

0.479

High

177716

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

11

Small-scale

0.479

High

177725

ANLN
Anillin

1

1

High-throughput

0.479

High

177729

UBP35
Ubiquitin carboxyl-terminal hydrolase 35

1

11

Small-scale

0.479

High

177730

HDAC6
Histone deacetylase 6

1

3

Small-scale

0.479

High

177733

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

1

2

Small-scale

0.479

High

177636

JTB
Protein JTB

1

0

Small-scale

0.458

High

177637

ATG12
Ubiquitin-like protein ATG12

1

0

Small-scale

0.458

High

177656

GPX4
Phospholipid hydroperoxide glutathione peroxidase GPX4

1

0

Small-scale

0.458

High

177711

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

0

Small-scale

0.458

High

177717

COQ7
5-demethoxyubiquinone hydroxylase, mitochondrial

1

0

Small-scale

0.458

High

177721

ATG5
Autophagy protein 5

1

0

Small-scale

0.458

High

177661

KCNJ6
G protein-activated inward rectifier potassium channel 2

1

1

Small-scale

0.457

High

177662

PAR2
Proteinase-activated receptor 2

1

1

Small-scale

0.437

High

177702

DEP1B
DEP domain-containing protein 1B

1

1

Small-scale

0.437

High

177708

NSUN4
5-methylcytosine rRNA methyltransferase NSUN4

1

1

Small-scale

0.437

High

177691

H31T
Histone H3.1t

1

6

Small-scale

0.408

High

177673

LTOR4
Ragulator complex protein LAMTOR4

2

0

High-throughput

0.328

High

177634

PTCD1
Pentatricopeptide repeat-containing protein 1, mitochondrial

1

0

Small-scale

0.249

Low

177692

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024