HitPredict

Interactor 1: MSH3 (P20585)
DNA mismatch repair protein Msh3 (hMSH3) (Divergent upstream protein) (DUP) (Mismatch repair protein 1) (MRP1)
Gene: MSH3

Interactor 2: MLH1 (P40692)
DNA mismatch repair protein Mlh1 (MutL protein homolog 1)
Gene: MLH1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.86 1.00 0.928

The method score is based on:

Property Details
Experiments 25416956, 29892012, 34469738, 17148452, 31515488
Identification Methods two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains HATPase_c_3~MutS_II, HATPase_c_3~MutS_III, HATPase_c_3~MutS_V
Common GO terms GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006298 - mismatch repair
GO:0016020 - membrane
and 2 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1137
Hs

1 756
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024