Protein: MYO5B
Unconventional myosin-Vb

Gene: MYO5B
Organism: Homo sapiens
Interactions: 112
UniProt ID: Q9ULV0

Gene Ontology (top 5):
GO:0000146 - microfilament motor activity
GO:0003091 - renal water homeostasis
GO:0005516 - calmodulin binding
GO:0005524 - ATP binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

976658

RB11A
Ras-related protein Rab-11A

6

9

Small-scale

0.937

High

945119

RAB25
Ras-related protein Rab-25

3

9

Small-scale

0.845

High

1155402

RB11B
Ras-related protein Rab-11B

3

10

Small-scale

0.845

High

534004

MLRV
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform

2

13

High-throughput

0.811

High

956026

RAB8A
Ras-related protein Rab-8A

2

9

Small-scale

0.757

High

773076

MYH9
Myosin-9

1

15

High-throughput

0.691

High

863026

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

6

High-throughput

0.691

High

993927

TNNC1
Troponin C, slow skeletal and cardiac muscles

1

11

High-throughput

0.691

High

1365616

MY18A
Unconventional myosin-XVIIIa

1

18

High-throughput

0.691

High

1392694

MYO19
Unconventional myosin-XIX

1

20

High-throughput

0.691

High

702058

TMOD1
Tropomodulin-1

4

8

High-throughput

0.691

High

1419265

TRI54
Tripartite motif-containing protein 54

3

11

High-throughput

0.675

High

1461760

AMOL2
Angiomotin-like protein 2

3

16

High-throughput

0.675

High

828470

PEX19
Peroxisomal biogenesis factor 19

3

3

High-throughput

0.667

High

1447427

ANLN
Anillin

3

4

High-throughput

0.656

High

277969

SH3L1
Adapter SH3BGRL

3

2

High-throughput

0.650

High

1092038

BNIP2
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2

3

0

High-throughput

0.646

High

1134766

NUMA1
Nuclear mitotic apparatus protein 1

3

18

High-throughput

0.640

High

1452688

TMOD3
Tropomodulin-3

2

8

High-throughput

0.628

High

630663

RAB3B
Ras-related protein Rab-3B

1

13

Small-scale

0.618

High

988821

RAC1
Ras-related C3 botulinum toxin substrate 1

1

2

High-throughput

0.618

High

1272896

RFIP2
Rab11 family-interacting protein 2

2

5

Small-scale

0.614

High

279075

TRIM3
Tripartite motif-containing protein 3

2

6

High-throughput

0.606

High

1430638

CCDC8
Coiled-coil domain-containing protein 8

2

6

High-throughput

0.584

High

169158

ML12B
Myosin regulatory light chain 12B

1

13

High-throughput

0.575

High

516603

CALM3
Calmodulin-3

1

10

High-throughput

0.575

High

273728

PP6R2
Serine/threonine-protein phosphatase 6 regulatory subunit 2

2

4

High-throughput

0.574

High

1458593

DKK3
Dickkopf-related protein 3

2

2

High-throughput

0.574

High

564552

CFTR
Cystic fibrosis transmembrane conductance regulator

2

8

Small-scale

0.571

High

1097173

MK07
Mitogen-activated protein kinase 7

2

4

High-throughput

0.571

High

1387359

LRC39
Leucine-rich repeat-containing protein 39

2

7

High-throughput

0.558

High

1206449

EFHC2
EF-hand domain-containing family member C2

2

4

High-throughput

0.553

High

1272362

ATOSB
Atos homolog protein B

2

1

High-throughput

0.553

High

1394285

GMCL1
Germ cell-less protein-like 1

2

3

High-throughput

0.553

High

1389621

SAAL1
Protein SAAL1

2

2

High-throughput

0.549

High

169283

CASQ2
Calsequestrin-2

1

2

High-throughput

0.536

High

277435

TP4A3
Protein tyrosine phosphatase type IVA 3

1

2

High-throughput

0.536

High

354045

CX001
Putative transmembrane protein CXorf1

1

2

High-throughput

0.536

High

355045

CHK2
Serine/threonine-protein kinase Chk2

1

9

High-throughput

0.536

High

505663

DC8L2
DDB1- and CUL4-associated factor 8-like protein 2

1

6

High-throughput

0.536

High

866865

CAZA2
F-actin-capping protein subunit alpha-2

1

6

High-throughput

0.536

High

920529

DAPK1
Death-associated protein kinase 1

1

9

High-throughput

0.536

High

968481

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

7

High-throughput

0.536

High

984025

RBX1
E3 ubiquitin-protein ligase RBX1

1

3

High-throughput

0.536

High

1092837

MALL
MAL-like protein

1

1

High-throughput

0.536

High

1154303

UB2V2
Ubiquitin-conjugating enzyme E2 variant 2

1

1

High-throughput

0.536

High

1160796

DREB
Drebrin

1

3

High-throughput

0.536

High

1325465

SYNPO
Synaptopodin

1

5

High-throughput

0.536

High

1352232

TBCK
TBC domain-containing protein kinase-like protein

1

5

High-throughput

0.536

High

1453101

CLIC5
Chloride intracellular channel protein 5

1

2

High-throughput

0.536

High

1459749

LIMA1
LIM domain and actin-binding protein 1

1

3

High-throughput

0.536

High

900221

FXR1
RNA-binding protein FXR1

1

0

High-throughput

0.518

High

903280

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

0

High-throughput

0.518

High

387155

TNNC2
Troponin C, skeletal muscle

1

13

High-throughput

0.514

High

1086724

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

0

High-throughput

0.513

High

800165

COIL
Coilin

1

1

High-throughput

0.508

High

1417985

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

5

High-throughput

0.494

High

317099

DPM2
Dolichol phosphate-mannose biosynthesis regulatory protein

1

2

High-throughput

0.489

High

1009630

CXCL6
C-X-C motif chemokine 6

1

2

High-throughput

0.489

High

1093784

GAGE5
G antigen 5

1

2

High-throughput

0.489

High

1388121

ERLEC
Endoplasmic reticulum lectin 1

1

2

High-throughput

0.489

High

180435

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

1

High-throughput

0.481

High

894246

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.481

High

227705

SPOP
Speckle-type POZ protein

1

3

High-throughput

0.479

High

249016

EVI5
Ecotropic viral integration site 5 protein homolog

1

1

Small-scale

0.479

High

344039

HS74L
Heat shock 70 kDa protein 4L

1

5

High-throughput

0.479

High

414835

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

487876

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.479

High

520447

ANDR
Androgen receptor

1

10

High-throughput

0.479

High

576698

GBRA1
Gamma-aminobutyric acid receptor subunit alpha-1

1

1

High-throughput

0.479

High

765113

CTNB1
Catenin beta-1

1

2

High-throughput

0.479

High

971278

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

1035986

KIF23
Kinesin-like protein KIF23

1

4

High-throughput

0.479

High

1093334

FLII
Protein flightless-1 homolog

1

7

High-throughput

0.479

High

1100736

STX3
Syntaxin-3

1

1

Small-scale

0.479

High

1125258

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

5

High-throughput

0.479

High

1141027

KIF14
Kinesin-like protein KIF14

1

4

High-throughput

0.479

High

1256072

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.479

High

1313004

S35F2
Solute carrier family 35 member F2

1

1

Small-scale

0.479

High

1328734

FHI1B
FHF complex subunit HOOK-interacting protein 1B

1

2

High-throughput

0.479

High

1361640

SSH1
Protein phosphatase Slingshot homolog 1

1

2

High-throughput

0.479

High

1385448

SYTL4
Synaptotagmin-like protein 4

1

3

Small-scale

0.479

High

1401445

CIC
Protein capicua homolog

1

2

High-throughput

0.479

High

1434215

PKHA4
Pleckstrin homology domain-containing family A member 4

1

11

High-throughput

0.479

High

1436551

ECT2
Protein ECT2

1

4

High-throughput

0.479

High

1458540

HDAC6
Protein deacetylase HDAC6

1

9

High-throughput

0.479

High

1461759

TBC30
TBC1 domain family member 30

1

1

Small-scale

0.479

High

1232639

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.470

High

1439276

K1549
UPF0606 protein KIAA1549

1

2

Small-scale

0.464

High

533061

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.458

High

668236

CXCR2
C-X-C chemokine receptor type 2

1

0

Small-scale

0.458

High

1060246

B2CL1
Bcl-2-like protein 1

1

0

High-throughput

0.458

High

1390549

CDCA5
Sororin

1

0

High-throughput

0.458

High

1459292

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1420762

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.445

High

1461758

ITM2B
Integral membrane protein 2B

1

4

High-throughput

0.445

High

1197592

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

7

High-throughput

0.437

High

1347257

EXOC6
Exocyst complex component 6

1

2

Small-scale

0.437

High

1367573

ESR2
Estrogen receptor beta

1

10

High-throughput

0.437

High

1033441

CDR2
Cerebellar degeneration-related protein 2

1

0

High-throughput

0.426

High

1429884

TOLIP
Toll-interacting protein

1

0

High-throughput

0.426

High

51517

FSD2
Fibronectin type III and SPRY domain-containing protein 2

1

8

High-throughput

0.407

High

255286

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

2

High-throughput

0.407

High

1103443

CTBP1
C-terminal-binding protein 1

1

1

High-throughput

0.407

High

1395428

NEUL4
Neuralized-like protein 4

1

3

High-throughput

0.407

High

587256

ITF2
Transcription factor 4

3

0

High-throughput

0.352

High

71535

MEI4
Meiosis-specific protein MEI4

2

0

High-throughput

0.316

High

211666

ZNHI1
Zinc finger HIT domain-containing protein 1

2

0

High-throughput

0.316

High

1311990

SKA3
Spindle and kinetochore-associated protein 3

1

0

High-throughput

0.279

Low

317947

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.249

Low

1438291

DEFM
Peptide deformylase, mitochondrial

1

0

High-throughput

0.249

Low

261319

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025