HitPredict

Interactor 1: MSH3 (P20585)
DNA mismatch repair protein Msh3 (hMSH3) (Divergent upstream protein) (DUP) (Mismatch repair protein 1) (MRP1)
Gene: MSH3

Interactor 2: RFA4 (Q13156)
Replication protein A 30 kDa subunit (RP-A p30) (Replication factor A protein 4) (RF-A protein 4)
Gene: RPA4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	37827155, 19468048
Identification Methods	affinity chromatography technology, proximity labelling technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006281 - DNA repair
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 1137 Hs			1 261
+	Hs
		551929 MSH3_HUMAN (1-1137): 0: 1303: 100.00		RFA2_HUMAN (1-261): 7.63e-105: 306: 42.03
+	Hs
		552296 MSH6_HUMAN (81-1126): 0: 978: 22.85		RFA2_HUMAN (1-261): 7.63e-105: 306: 42.03
+	Hs
		794243 MSH2_HUMAN (239-1127): 0: 777: 23.81		RFA4_HUMAN (1-261): 1.82e-106: 310: 100.00
+	Hs
		552147 MSH2_HUMAN (239-1127): 0: 777: 23.81		RFA2_HUMAN (1-261): 7.63e-105: 306: 42.03
+	Sc
		644772 MSH6_YEAST (109-1113): 0: 807: 23.68		RFA2_YEAST (6-257): 2.32e-67: 211: 23.38