HitPredict

Interactor 1: NTF3 (P20783)
Neurotrophin-3 (NT-3) (HDNF) (Nerve growth factor 2) (NGF-2) (Neurotrophic factor)
Gene: NTF3

Interactor 2: BDNF (P23560)
Brain-derived neurotrophic factor (BDNF) (Abrineurin) [Cleaved into: BDNF precursor form (ProBDNF)]
Gene: BDNF

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.64 1.00 0.806

The method score is based on:

Property Details
Experiments 7703225, 33961781
Identification Methods x-ray crystallography, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type association, physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains NGF~NGF
Common GO terms GO:0005163 - nerve growth factor receptor binding
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway
GO:0007399 - nervous system development
and 13 others

more...
Homologous interactions 5

Homologous interactions

Color coding for hit scores

1 257
Hs

1 247
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024