HitPredict

Interactor 1: MAK (P20794)
Serine/threonine-protein kinase MAK (EC 2.7.11.1) (Male germ cell-associated kinase)
Gene: MAK

Interactor 2: CDK20 (Q8IZL9)
Cyclin-dependent kinase 20 (EC 2.7.11.22) (CDK-activating kinase p42) (CAK-kinase p42) (Cell cycle-related kinase) (Cell division protein kinase 20) (Cyclin-dependent protein kinase H) (Cyclin-kinase-activating kinase p42)
Gene: CDK20

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	21986944
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Pkinase
Common GO terms	GO:0004674 - protein serine/threonine kinase activity GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005929 - cilium and 1 others more... GO:0106310 - protein serine kinase activity
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 623 Hs			1 346
+	Hs
		1224591 CILK1_HUMAN (1-623): 1.43e-158: 471: 53.47		CDK20_HUMAN (1-346): 2.32e-134: 387: 100.00
+	Hs
		415108 CILK1_HUMAN (1-623): 1.43e-158: 471: 53.47		CDK1_HUMAN (1-292): 1.16e-131: 379: 42.18
+	Hs
		625115 CDK2_HUMAN (1-290): 5.51e-144: 421: 37.54		CDK2_HUMAN (1-296): 5.66e-140: 400: 43.10
+	Hs
		625363 CDK2_HUMAN (1-290): 5.51e-144: 421: 37.54		CDK3_HUMAN (1-308): 3.83e-138: 395: 44.66
+	Hs
		625512 CDK2_HUMAN (1-290): 5.51e-144: 421: 37.54		CDK20_HUMAN (1-346): 2.32e-134: 387: 100.00
+	Hs
		414746 CDK2_HUMAN (1-290): 5.51e-144: 421: 37.54		CDK1_HUMAN (1-292): 1.16e-131: 379: 42.18
+	Zm
		1736 A0A096S009_MAIZE (2-539): 1.59e-137: 415: 23.20		A0A096S009_MAIZE (2-335): 1.92e-128: 381: 31.20
+	Hs
		414864 CDK3_HUMAN (1-297): 6.33e-142: 416: 36.67		CDK1_HUMAN (1-292): 1.16e-131: 379: 42.18
+	Hs
		625243 CDK2_HUMAN (1-290): 5.51e-144: 421: 37.54		CDK7_HUMAN (3-304): 2.01e-127: 370: 42.62
+	Hs
		625365 CDK2_HUMAN (1-290): 5.51e-144: 421: 37.54		CDK5_HUMAN (1-294): 2.23e-128: 370: 45.09
+	At
		1106290 MPK4_ARATH (7-332): 4.29e-136: 404: 33.33		MPK4_ARATH (7-334): 3.11e-132: 383: 32.04
+	Hs
		960080 CDK3_HUMAN (1-297): 6.33e-142: 416: 36.67		CDK5_HUMAN (1-294): 2.23e-128: 370: 45.09
+	At
		794967 MHK_ARATH (1-323): 4.17e-136: 406: 52.01		MPK6_ARATH (9-327): 1.23e-129: 377: 33.64
+	At
		98290 F4JSF8_ARATH (1-438): 1.15e-133: 401: 43.84		F4JSF8_ARATH (1-343): 1e-130: 382: 31.78
+	Hs
		414679 CDK1_HUMAN (1-289): 1.21e-135: 399: 38.23		CDK1_HUMAN (1-292): 1.16e-131: 379: 42.18
+	Zm
		75520 B4FJ92_MAIZE (1-427): 2.67e-134: 401: 43.72		B4FJ92_MAIZE (1-325): 3.57e-128: 375: 36.31
+	Hs
		414826 CDK1_HUMAN (1-289): 1.21e-135: 399: 38.23		CDK7_HUMAN (3-304): 2.01e-127: 370: 42.62