Protein: PTN12
Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1)

Gene: PTN12, PTPN12
Organism: Homo sapiens
Interactions: 146
UniProt ID: Q05209

Gene Ontology (top 5):
GO:0002102 - podosome
GO:0004721 - phosphoprotein phosphatase activity
GO:0004725 - protein tyrosine phosphatase activity
GO:0004726 - non-membrane spanning protein tyrosine phosphatase activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

711319

SHC1
SHC-transforming protein 1

11

20

Small-scale

0.983

High

363164

EGFR
Epidermal growth factor receptor

6

20

Small-scale

0.950

High

711105

PTN6
Tyrosine-protein phosphatase non-receptor type 6

5

17

High-throughput

0.912

High

987566

GRB2
Growth factor receptor-bound protein 2

3

20

Small-scale

0.870

High

484113

PGFRB
Platelet-derived growth factor receptor beta

3

20

Small-scale

0.817

High

878437

PAXI
Paxillin

10

15

Small-scale

0.759

High

834177

CSK
Tyrosine-protein kinase CSK

2

20

High-throughput

0.754

High

1050781

PTN12
Tyrosine-protein phosphatase non-receptor type 12

2

18

High-throughput

0.754

High

222061

NCK2
Cytoplasmic protein NCK2

2

20

High-throughput

0.737

High

410791

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

20

Small-scale

0.737

High

582756

EZRI
Ezrin

2

5

High-throughput

0.737

High

220765

PPIP1
Proline-serine-threonine phosphatase-interacting protein 1

6

15

Small-scale

0.735

High

1050822

PPIP2
Proline-serine-threonine phosphatase-interacting protein 2

6

13

High-throughput

0.734

High

942572

BCAR1
Breast cancer anti-estrogen resistance protein 1

5

14

Small-scale

0.727

High

1050829

VAPA
Vesicle-associated membrane protein-associated protein A

5

5

High-throughput

0.712

High

641161

FGFR2
Fibroblast growth factor receptor 2

1

20

High-throughput

0.698

High

778054

VGFR2
Vascular endothelial growth factor receptor 2

1

20

High-throughput

0.698

High

1050786

PTK7
Inactive tyrosine-protein kinase 7

1

20

High-throughput

0.698

High

1050795

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.698

High

253943

LPXN
Leupaxin

3

16

High-throughput

0.662

High

411782

NTRK1
High affinity nerve growth factor receptor

2

20

High-throughput

0.659

High

1050790

FAK2
Protein-tyrosine kinase 2-beta

1

20

Small-scale

0.647

High

637467

FLNA
Filamin-A

3

3

High-throughput

0.633

High

465494

IGF1R
Insulin-like growth factor 1 receptor

1

20

High-throughput

0.625

High

641576

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

High-throughput

0.625

High

648491

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.625

High

1034220

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

20

High-throughput

0.625

High

1050803

LMTK1
Serine/threonine-protein kinase LMTK1

1

20

High-throughput

0.625

High

1050810

LMTK2
Serine/threonine-protein kinase LMTK2

1

20

High-throughput

0.625

High

253340

JAK2
Tyrosine-protein kinase JAK2

1

20

Small-scale

0.618

High

593971

NCK1
SH2/SH3 adapter protein NCK1

1

20

High-throughput

0.618

High

619032

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

6

High-throughput

0.618

High

1050782

FAK1
Focal adhesion kinase 1

1

20

High-throughput

0.618

High

1050805

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.618

High

332977

VAPB
Vesicle-associated membrane protein-associated protein B/C

2

5

High-throughput

0.611

High

421969

A4
Amyloid-beta precursor protein

2

7

High-throughput

0.602

High

49966

RHG10
Rho GTPase-activating protein 10

2

4

High-throughput

0.584

High

440041

LCK
Tyrosine-protein kinase Lck

1

20

High-throughput

0.575

High

533843

GHR
Growth hormone receptor

1

20

High-throughput

0.575

High

840875

TEC
Tyrosine-protein kinase Tec

1

20

High-throughput

0.575

High

1038427

TIE2
Angiopoietin-1 receptor

1

20

High-throughput

0.575

High

1050783

ACK1
Activated CDC42 kinase 1

1

20

High-throughput

0.575

High

212721

TGFI1
Transforming growth factor beta-1-induced transcript 1 protein

1

16

Small-scale

0.573

High

240081

KPRB
Phosphoribosyl pyrophosphate synthase-associated protein 2

2

3

High-throughput

0.571

High

415518

HSPB1
Heat shock protein beta-1

2

4

High-throughput

0.571

High

466218

RHOC
Rho-related GTP-binding protein RhoC

2

20

High-throughput

0.571

High

521658

H14
Histone H1.4

2

1

High-throughput

0.571

High

537023

HSP7C
Heat shock cognate 71 kDa protein

2

7

High-throughput

0.571

High

549571

PRPS2
Ribose-phosphate pyrophosphokinase 2

2

3

High-throughput

0.571

High

595751

H13
Histone H1.3

2

1

High-throughput

0.571

High

600796

HSP76
Heat shock 70 kDa protein 6

2

7

High-throughput

0.571

High

687788

SYVC
Valine--tRNA ligase

2

2

High-throughput

0.571

High

842641

WASP
Actin nucleation-promoting factor WAS

2

10

Small-scale

0.571

High

954457

PRPS1
Ribose-phosphate pyrophosphokinase 1

2

3

High-throughput

0.571

High

961979

RHOA
Transforming protein RhoA

2

20

High-throughput

0.571

High

964103

RL37
Large ribosomal subunit protein eL37

2

1

High-throughput

0.571

High

993142

ACTG
Actin, cytoplasmic 2

2

5

High-throughput

0.571

High

994997

CSK2B
Casein kinase II subunit beta

2

1

High-throughput

0.571

High

1008102

PRKDC
DNA-dependent protein kinase catalytic subunit

2

2

High-throughput

0.571

High

1050784

DUS4
Dual specificity protein phosphatase 4

2

7

High-throughput

0.571

High

1050789

DX39B
Spliceosome RNA helicase DDX39B

2

2

High-throughput

0.571

High

1050793

KPRA
Phosphoribosyl pyrophosphate synthase-associated protein 1

2

3

High-throughput

0.571

High

320235

SRBS2
Sorbin and SH3 domain-containing protein 2

1

20

Small-scale

0.561

High

532072

KIT
Mast/stem cell growth factor receptor Kit

1

20

Small-scale

0.553

High

446934

NPM
Nucleophosmin

2

0

High-throughput

0.547

High

657899

SYWC
Tryptophan--tRNA ligase, cytoplasmic

2

0

High-throughput

0.547

High

724742

METK2
S-adenosylmethionine synthase isoform type-2

2

0

High-throughput

0.547

High

1050796

SF3A1
Splicing factor 3A subunit 1

2

0

High-throughput

0.547

High

1050802

RBP10
Ran-binding protein 10

2

0

High-throughput

0.547

High

1050806

PHF5A
PHD finger-like domain-containing protein 5A

2

0

High-throughput

0.547

High

1050809

MGAP
MAX gene-associated protein

2

0

High-throughput

0.547

High

1050812

CCAR2
Cell cycle and apoptosis regulator protein 2

2

0

High-throughput

0.547

High

1050814

RM50
Large ribosomal subunit protein mL50

2

0

High-throughput

0.547

High

943039

STX17
Syntaxin-17

1

1

High-throughput

0.541

High

1025870

FANCC
Fanconi anemia group C protein

1

1

High-throughput

0.541

High

1050797

SMAD1
Mothers against decapentaplegic homolog 1

1

2

High-throughput

0.541

High

1050801

SFRP4
Secreted frizzled-related protein 4

1

2

High-throughput

0.541

High

1050816

AN32B
Acidic leucine-rich nuclear phosphoprotein 32 family member B

1

6

High-throughput

0.541

High

1050818

CANB2
Calcineurin subunit B type 2

1

2

High-throughput

0.541

High

1050836

ZN510
Zinc finger protein 510

1

1

High-throughput

0.541

High

348475

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

2

High-throughput

0.536

High

991500

DYL1
Dynein light chain 1, cytoplasmic

1

1

High-throughput

0.536

High

1050787

RM49
Large ribosomal subunit protein mL49

2

2

High-throughput

0.521

High

282985

FRAT2
GSK-3-binding protein FRAT2

1

0

High-throughput

0.518

High

439707

INSR
Insulin receptor

1

20

High-throughput

0.514

High

472044

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.514

High

160886

STX16
Syntaxin-16

1

7

High-throughput

0.508

High

856654

BAG6
Large proline-rich protein BAG6

1

3

High-throughput

0.508

High

1050819

SMAD5
Mothers against decapentaplegic homolog 5

1

2

High-throughput

0.508

High

211985

EFS
Embryonal Fyn-associated substrate

1

12

Small-scale

0.501

High

1050792

CASL
Enhancer of filamentation 1

1

8

Small-scale

0.501

High

451370

NFM
Neurofilament medium polypeptide

1

2

High-throughput

0.489

High

862635

UTRN
Utrophin

1

0

High-throughput

0.486

High

1050804

ZFP2
Zinc finger protein ZFP2

1

0

High-throughput

0.486

High

1050811

IFT20
Intraflagellar transport protein 20 homolog

1

0

High-throughput

0.486

High

1050821

THAP2
THAP domain-containing protein 2

1

0

High-throughput

0.486

High

1050828

TEX10
Testis-expressed protein 10

1

0

High-throughput

0.486

High

1050837

RBM19
Probable RNA-binding protein 19

1

0

High-throughput

0.486

High

1050833

TEN1
Teneurin-1

1

5

Small-scale

0.481

High

218089

TGON2
Trans-Golgi network integral membrane protein 2

1

5

High-throughput

0.479

High

278063

FLNB
Filamin-B

1

3

High-throughput

0.479

High

343938

HS74L
Heat shock 70 kDa protein 4L

1

9

High-throughput

0.479

High

371832

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.479

High

442300

GELS
Gelsolin

1

1

Small-scale

0.479

High

613339

VINC
Vinculin

1

1

High-throughput

0.479

High

631183

RAB5A
Ras-related protein Rab-5A

1

6

High-throughput

0.479

High

703548

MK01
Mitogen-activated protein kinase 1

1

15

High-throughput

0.479

High

788300

GPX4
Phospholipid hydroperoxide glutathione peroxidase GPX4

1

2

High-throughput

0.479

High

891129

GSK3A
Glycogen synthase kinase-3 alpha

1

3

High-throughput

0.479

High

891479

GSK3B
Glycogen synthase kinase-3 beta

1

11

High-throughput

0.479

High

1045199

TF65
Transcription factor p65

1

3

High-throughput

0.479

High

1050791

FLNC
Filamin-C

1

3

High-throughput

0.479

High

1050798

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.479

High

1050799

MK06
Mitogen-activated protein kinase 6

1

16

High-throughput

0.479

High

1050807

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

1050808

CARM1
Histone-arginine methyltransferase CARM1

1

1

High-throughput

0.479

High

1050815

WASF1
Actin-binding protein WASF1

1

6

Small-scale

0.479

High

1050817

DYL2
Dynein light chain 2, cytoplasmic

1

1

High-throughput

0.479

High

1050823

NANOG
Homeobox protein NANOG

1

1

High-throughput

0.479

High

1050831

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

1050834

ASAP1
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

1

2

High-throughput

0.479

High

1050835

RHG26
Rho GTPase-activating protein 26

1

6

High-throughput

0.479

High

1027914

PSG9
Pregnancy-specific beta-1-glycoprotein 9

1

14

High-throughput

0.464

High

646824

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.458

High

1050794

EEA1
Early endosome antigen 1

1

0

High-throughput

0.458

High

1050820

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

1050824

CPAP
Centrosomal P4.1-associated protein

1

0

High-throughput

0.458

High

1050826

CASS4
Cas scaffolding protein family member 4

1

9

High-throughput

0.457

High

193556

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

10

High-throughput

0.445

High

618245

CADH2
Cadherin-2

1

20

High-throughput

0.445

High

764687

CTNB1
Catenin beta-1

1

20

High-throughput

0.445

High

857089

NSF
Vesicle-fusing ATPase

1

16

High-throughput

0.445

High

1007673

RAE1L
mRNA export factor RAE1

1

2

High-throughput

0.445

High

1050785

NMDE2
Glutamate receptor ionotropic, NMDA 2B

1

13

High-throughput

0.445

High

1050788

GAB1
GRB2-associated-binding protein 1

1

18

High-throughput

0.445

High

76625

B4DZK1
cDNA FLJ50036, weakly similar to Myosin-11

1

1

High-throughput

0.439

High

1050827

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

1050830

CC180
Coiled-coil domain-containing protein 180

1

1

High-throughput

0.417

High

689817

CD27
CD27 antigen

1

8

High-throughput

0.407

High

1050825

RM47
Large ribosomal subunit protein uL29m

2

0

High-throughput

0.298

High

1050832

DPP2
Dipeptidyl peptidase 2

2

0

High-throughput

0.298

High

377109

GLHA
Glycoprotein hormones alpha chain

1

0

High-throughput

0.265

Low

516043

CSH2
Chorionic somatomammotropin hormone 2

1

0

High-throughput

0.251

Low

1050800

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low

1050813

Q8N5B1
Uncharacterized protein

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025