HitPredict

Interactor 1: HNF1A (P20823)
Hepatocyte nuclear factor 1-alpha (HNF-1-alpha) (HNF-1A) (Liver-specific transcription factor LF-B1) (LFB1) (Transcription factor 1) (TCF-1)
Gene: HNF1A

Interactor 2: PHS (P61457)
Pterin-4-alpha-carbinolamine dehydratase (PHS) (EC 4.2.1.96) (4-alpha-hydroxy-tetrahydropterin dehydratase) (Dimerization cofactor of hepatocyte nuclear factor 1-alpha) (DCoH) (Dimerization cofactor of HNF1) (Phenylalanine hydroxylase-stimulating protein) (Pterin carbinolamine dehydratase) (PCD)
Gene: PCBD1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	0.50	0.659

Property	Details
Experiments	17353931, 9092652, 35140242, 21047120, 21988832
Identification Methods	affinity chromatography technology, pull down, two hybrid, proximity labelling technology, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 631 Hs			1 104
+	Hs
		595955 HNF1A_HUMAN (1-631): 0: 635: 100.00		PHS2_HUMAN (1-103): 1.58e-46: 147: 61.17
+	Mm
		607521 HNF1A_MOUSE (1-631): 0: 617: 94.61		PHS_MOUSE (1-104): 3.02e-50: 155: 99.04
+	Mm
		607525 HNF1A_MOUSE (1-631): 0: 617: 94.61		PHS2_MOUSE (1-103): 7.64e-49: 153: 66.02
+	Mm
		655008 HNF1B_MOUSE (1-541): 1.04e-153: 456: 53.98		PHS_MOUSE (1-104): 3.02e-50: 155: 99.04
+	Hs
		727496 HNF1B_HUMAN (1-541): 1.27e-150: 448: 53.21		PHS_HUMAN (1-104): 6.3e-50: 154: 100.00
+	Hs
		727585 HNF1B_HUMAN (1-541): 1.27e-150: 448: 53.21		PHS2_HUMAN (1-103): 1.58e-46: 147: 61.17