HitPredict

Interactor 1: HNF1A (P20823)
Hepatocyte nuclear factor 1-alpha (HNF-1-alpha) (HNF-1A) (Liver-specific transcription factor LF-B1) (LFB1) (Transcription factor 1) (TCF-1)
Gene: HNF1A

Interactor 2: KMT2C (Q8NEZ4)
Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3)
Gene: KMT2C

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35140242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 631 Hs			1 4911
+	Hs
		727560 HNF1B_HUMAN (1-541): 1.27e-150: 448: 53.21		KMT2C_HUMAN (1-4911): 0: 2416: 100.00
+	Hs
		620175 PAX7_HUMAN (99-466): 9.66e-75: 249: 16.50		KMT2C_HUMAN (1-4911): 0: 2416: 100.00
+	Hs
		641482 PAX6_HUMAN (99-431): 2.16e-54: 192: 13.28		KMT2C_HUMAN (1-4911): 0: 2416: 100.00
+	Hs
		152587 HNF1A_HUMAN (1-631): 0: 635: 100.00		KMT2D_HUMAN (2766-3637): 7.14e-09: 65: 8.82
+	Hs
		727571 HNF1B_HUMAN (1-541): 1.27e-150: 448: 53.21		DPF1_HUMAN (350-435): 3.04e-13: 77: 40.45
+	Hs
		727572 HNF1B_HUMAN (1-541): 1.27e-150: 448: 53.21		REQU_HUMAN (359-435): 2.72e-12: 74.3: 41.25
+	Hs
		152601 HNF1B_HUMAN (1-541): 1.27e-150: 448: 53.21		KMT2D_HUMAN (2766-3637): 7.14e-09: 65: 8.82
+	Hs
		641393 PAX6_HUMAN (99-431): 2.16e-54: 192: 13.28		CHD3_HUMAN (390-526): 1.86e-31: 139: 21.38
+	Hs
		1018535 HMBX1_HUMAN (93-297): 7.36e-53: 188: 26.61		CHD3_HUMAN (390-526): 1.86e-31: 139: 21.38
+	Hs
		620184 PAX7_HUMAN (99-466): 9.66e-75: 249: 16.50		DPF1_HUMAN (350-435): 3.04e-13: 77: 40.45
+	Hs
		620185 PAX7_HUMAN (99-466): 9.66e-75: 249: 16.50		REQU_HUMAN (359-435): 2.72e-12: 74.3: 41.25
+	Hs
		152588 PAX7_HUMAN (99-466): 9.66e-75: 249: 16.50		KMT2D_HUMAN (2766-3637): 7.14e-09: 65: 8.82
+	Dm
		1359818 Q9V490_DROME (100-469): 1.31e-39: 154: 12.56		Q9W1H0_DROME (954-1243): 2.58e-36: 155: 22.77
+	Dm
		112013 L0MPR7_DROME (100-465): 3.8e-36: 144: 13.44		Q9W1H0_DROME (954-1243): 2.58e-36: 155: 22.77
+	Hs
		641503 PAX6_HUMAN (99-431): 2.16e-54: 192: 13.28		DPF1_HUMAN (350-435): 3.04e-13: 77: 40.45
+	Hs
		641504 PAX6_HUMAN (99-431): 2.16e-54: 192: 13.28		REQU_HUMAN (359-435): 2.72e-12: 74.3: 41.25
+	Hs
		1156037 HMBX1_HUMAN (93-297): 7.36e-53: 188: 26.61		REQU_HUMAN (359-435): 2.72e-12: 74.3: 41.25
+	Hs
		152592 PAX6_HUMAN (99-431): 2.16e-54: 192: 13.28		KMT2D_HUMAN (2766-3637): 7.14e-09: 65: 8.82
+	Dm
		1179567 Q9XZU0_DROME (194-437): 5.53e-38: 146: 17.81		Q7K3G5_DROME (359-435): 1.38e-13: 79: 42.50
+	Dm
		1179548 Q8T0V5_DROME (194-437): 8.71e-38: 145: 17.81		Q7K3G5_DROME (359-435): 1.38e-13: 79: 42.50