HitPredict

Interactor 1: HNF1A (P20823)
Hepatocyte nuclear factor 1-alpha (HNF-1-alpha) (HNF-1A) (Liver-specific transcription factor LF-B1) (LFB1) (Transcription factor 1) (TCF-1)
Gene: HNF1A

Interactor 2: CBP (Q92793)
CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-)
Gene: CREBBP

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	10777539, 15598887
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 631 Hs			1 2442
+	Hs
		727573 HNF1B_HUMAN (1-541): 1.27e-150: 448: 53.21		CBP_HUMAN (1-2442): 0: 1104: 100.00
+	Mm
		101426 HNF1B_MOUSE (1-541): 1.04e-153: 456: 53.98		F8VPR5_MOUSE (1-2442): 0: 1077: 95.67
+	Hs
		595924 HNF1A_HUMAN (1-631): 0: 635: 100.00		EP300_HUMAN (1-2426): 0: 874: 55.06
+	Hs
		620186 PAX7_HUMAN (99-466): 9.66e-75: 249: 16.50		CBP_HUMAN (1-2442): 0: 1104: 100.00
+	Hs
		727512 HNF1B_HUMAN (1-541): 1.27e-150: 448: 53.21		EP300_HUMAN (1-2426): 0: 874: 55.06
+	Hs
		620147 PAX7_HUMAN (99-466): 9.66e-75: 249: 16.50		EP300_HUMAN (1-2426): 0: 874: 55.06
+	Hs
		641388 PAX6_HUMAN (99-431): 2.16e-54: 192: 13.28		EP300_HUMAN (1-2426): 0: 874: 55.06
+	Hs
		595941 HNF1A_HUMAN (1-631): 0: 635: 100.00		KMT2C_HUMAN (1945-2437): 8.84e-10: 67.1: 13.89
+	Hs
		170278 HNF1B_HUMAN (1-541): 1.27e-150: 448: 53.21		TIF1A_HUMAN (667-1202): 2.17e-34: 147: 17.97
+	Hs
		727554 HNF1B_HUMAN (1-541): 1.27e-150: 448: 53.21		PB1_HUMAN (1040-1275): 1.29e-12: 76: 14.83
+	Hs
		727513 HNF1B_HUMAN (1-541): 1.27e-150: 448: 53.21		BPTF_HUMAN (1831-2314): 7.5e-12: 73.6: 11.09
+	Hs
		727603 HNF1B_HUMAN (1-541): 1.27e-150: 448: 53.21		CHD7_HUMAN (70-467): 2.16e-11: 72.1: 9.68
+	Hs
		727560 HNF1B_HUMAN (1-541): 1.27e-150: 448: 53.21		KMT2C_HUMAN (1945-2437): 8.84e-10: 67.1: 13.89
+	Hs
		170262 PAX6_HUMAN (99-431): 2.16e-54: 192: 13.28		TIF1A_HUMAN (667-1202): 2.17e-34: 147: 17.97
+	Hs
		620215 PAX7_HUMAN (99-466): 9.66e-75: 249: 16.50		CHD7_HUMAN (70-467): 2.16e-11: 72.1: 9.68
+	Hs
		620175 PAX7_HUMAN (99-466): 9.66e-75: 249: 16.50		KMT2C_HUMAN (1945-2437): 8.84e-10: 67.1: 13.89
+	Hs
		641466 PAX6_HUMAN (99-431): 2.16e-54: 192: 13.28		PB1_HUMAN (1040-1275): 1.29e-12: 76: 14.83
+	Hs
		641391 PAX6_HUMAN (99-431): 2.16e-54: 192: 13.28		BPTF_HUMAN (1831-2314): 7.5e-12: 73.6: 11.09
+	Hs
		203210 PAX6_HUMAN (99-431): 2.16e-54: 192: 13.28		SYNJ1_HUMAN (1984-2407): 1.04e-11: 73.3: 10.86
+	Hs
		641482 PAX6_HUMAN (99-431): 2.16e-54: 192: 13.28		KMT2C_HUMAN (1945-2437): 8.84e-10: 67.1: 13.89