Protein: AKAP5
A-kinase anchor protein 5 (AKAP-5) (A-kinase anchor protein 79 kDa) (AKAP 79) (H21) (cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein)

Gene: AKAP5
Organism: Homo sapiens
Interactions: 76
UniProt ID: P24588

Gene Ontology (top 5):
GO:0005516 - calmodulin binding
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0007165 - signal transduction
GO:0007193 - adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

665874

KAP3
cAMP-dependent protein kinase type II-beta regulatory subunit

7

5

Small-scale

0.745

High

605559

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

6

4

Small-scale

0.737

High

568759

KAP2
cAMP-dependent protein kinase type II-alpha regulatory subunit

6

5

Small-scale

0.731

High

651613

KAPCB
cAMP-dependent protein kinase catalytic subunit beta

5

4

High-throughput

0.725

High

665887

PP2BA
Protein phosphatase 3 catalytic subunit alpha

4

1

Small-scale

0.696

High

375184

RASK
GTPase KRas

3

3

High-throughput

0.640

High

650521

KAPCG
cAMP-dependent protein kinase catalytic subunit gamma

2

4

High-throughput

0.628

High

531000

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

2

5

High-throughput

0.606

High

603167

KPCA
Protein kinase C alpha type

2

8

Small-scale

0.584

High

665880

RHOB
Rho-related GTP-binding protein RhoB

2

1

High-throughput

0.584

High

665897

TRPV1
Transient receptor potential cation channel subfamily V member 1

1

6

Small-scale

0.561

High

665903

ROP1L
Ropporin-1-like protein

2

1

High-throughput

0.553

High

665906

ROP1A
Ropporin-1A

2

1

High-throughput

0.553

High

665871

GBRB3
Gamma-aminobutyric acid receptor subunit beta-3

1

0

Small-scale

0.537

High

665875

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

0

Small-scale

0.537

High

665877

HSP72
Heat shock-related 70 kDa protein 2

1

1

High-throughput

0.536

High

665901

TNPO1
Transportin-1

1

1

High-throughput

0.536

High

216377

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

0

High-throughput

0.513

High

443187

CDK1
Cyclin-dependent kinase 1

1

0

High-throughput

0.513

High

620137

NUCL
Nucleolin

1

0

High-throughput

0.513

High

665899

SMS2
Phosphatidylcholine:ceramide cholinephosphotransferase 2

1

0

High-throughput

0.513

High

665876

CLK1
Dual specificity protein kinase CLK1

1

1

High-throughput

0.489

High

665889

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

5

High-throughput

0.489

High

665900

IPO4
Importin-4

1

1

High-throughput

0.489

High

370567

FOS
Protein c-Fos

1

1

Small-scale

0.481

High

373779

RASN
GTPase NRas

1

3

High-throughput

0.479

High

536524

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

665872

EPHA2
Ephrin type-A receptor 2

1

1

High-throughput

0.479

High

665878

RHOA
Transforming protein RhoA

1

1

High-throughput

0.479

High

665890

RAB35
Ras-related protein Rab-35

1

1

High-throughput

0.479

High

665893

TRPM8
Transient receptor potential cation channel subfamily M member 8

1

4

Small-scale

0.479

High

665898

TRPV3
Transient receptor potential cation channel subfamily V member 3

1

7

Small-scale

0.479

High

665907

TRPV4
Transient receptor potential cation channel subfamily V member 4

1

6

Small-scale

0.479

High

665910

TRPV2
Transient receptor potential cation channel subfamily V member 2

1

6

Small-scale

0.479

High

413210

P53
Cellular tumor antigen p53

1

0

Small-scale

0.460

High

665883

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.460

High

164258

NRP1
Neuropilin-1

1

0

High-throughput

0.458

High

189422

STX7
Syntaxin-7

1

0

High-throughput

0.458

High

219774

KCNQ2
Potassium voltage-gated channel subfamily KQT member 2

1

0

Small-scale

0.458

High

292310

TRPA1
Transient receptor potential cation channel subfamily A member 1

1

0

Small-scale

0.458

High

299065

FLOT1
Flotillin-1

1

0

High-throughput

0.458

High

446658

NPM
Nucleophosmin

1

0

High-throughput

0.458

High

463338

LYN
Tyrosine-protein kinase Lyn

1

0

High-throughput

0.458

High

540314

LAMP1
Lysosome-associated membrane glycoprotein 1

1

0

High-throughput

0.458

High

574145

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

0

High-throughput

0.458

High

580598

AMPN
Aminopeptidase N

1

0

High-throughput

0.458

High

614651

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

1

0

High-throughput

0.458

High

665873

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

High-throughput

0.458

High

665879

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.458

High

665881

KCNJ2
Inward rectifier potassium channel 2

1

0

Small-scale

0.458

High

665884

CAV1
Caveolin-1

1

0

High-throughput

0.458

High

665885

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

665886

PRDX1
Peroxiredoxin-1

1

0

High-throughput

0.458

High

665891

OCLN
Occludin

1

0

High-throughput

0.458

High

665908

RXFP1
Relaxin receptor 1

1

0

Small-scale

0.458

High

665909

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

521546

H14
Histone H1.4

1

2

High-throughput

0.437

High

595317

H15
Histone H1.5

1

2

High-throughput

0.437

High

595946

H12
Histone H1.2

1

2

High-throughput

0.437

High

665896

RM43
Large ribosomal subunit protein mL43

1

1

High-throughput

0.437

High

665905

DERL1
Derlin-1

1

1

High-throughput

0.437

High

665888

PDE4D
3',5'-cyclic-AMP phosphodiesterase 4D

1

0

Small-scale

0.426

High

72957

B1AL05
Large ribosomal subunit protein mL43

1

1

High-throughput

0.407

High

76658

B4E1G1
Derlin

1

1

High-throughput

0.407

High

97117

E9PN89
Heat shock protein family A

1

2

High-throughput

0.407

High

292078

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

0

High-throughput

0.279

Low

330415

LC7L3
Luc7-like protein 3

1

0

High-throughput

0.279

Low

665882

H31
Histone H3.1

1

0

High-throughput

0.279

Low

665892

RSBNL
Lysine-specific demethylase RSBN1L

1

0

High-throughput

0.279

Low

665895

OTU6B
Deubiquitinase OTUD6B

1

0

High-throughput

0.279

Low

665904

RMXL1
RNA binding motif protein, X-linked-like-1

1

0

High-throughput

0.279

Low

429322

JUN
Transcription factor Jun

1

0

Small-scale

0.251

Low

181685

CTDSL
CTD small phosphatase-like protein

1

0

High-throughput

0.249

Low

327165

ZFPL1
Zinc finger protein-like 1

1

0

High-throughput

0.249

Low

665894

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

665902

CK052
Uncharacterized protein C11orf52

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025