HitPredict

Interactor 1: EFNA1 (P20827)
Ephrin-A1 (EPH-related receptor tyrosine kinase ligand 1) (LERK-1) (Immediate early response protein B61) (Tumor necrosis factor alpha-induced protein 4) (TNF alpha-induced protein 4) [Cleaved into: Ephrin-A1, secreted form]
Gene: EFNA1

Interactor 2: EPHA3 (P29320)
Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (hEK4) (HEK) (Human embryo kinase) (Tyrosine-protein kinase TYRO4) (Tyrosine-protein kinase receptor ETK1) (Eph-like tyrosine kinase 1)
Gene: EPHA3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	9195962
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ephrin~Ephrin_lbd
Common GO terms	GO:0005576 - extracellular region GO:0005886 - plasma membrane GO:0007411 - axon guidance GO:0016477 - cell migration GO:0048013 - ephrin receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 205 Hs			1 983
+	Hs
		665382 EFNA5_HUMAN (1-183): 5.49e-70: 214: 41.03		EPHA3_HUMAN (1-983): 0: 1248: 100.00
+	Hs
		595976 EFNA1_HUMAN (1-205): 2.54e-101: 293: 100.00		EPHB2_HUMAN (29-981): 0: 1167: 55.90
+	Hs
		595985 EFNA1_HUMAN (1-205): 2.54e-101: 293: 100.00		EPHA4_HUMAN (8-983): 0: 1164: 62.40
+	Mm
		139054 EFNA5_MOUSE (1-183): 2.06e-69: 213: 40.51		Q8BRB1_MOUSE (1-983): 0: 1240: 96.44
+	Dr
		47532 A0A8M1Q1X6_DANRE (3-188): 1.44e-75: 228: 40.20		Q5ZEW1_DANRE (8-980): 0: 1205: 60.66
+	Hs
		217642 EFNA2_HUMAN (16-195): 1.15e-71: 218: 41.89		EPHA7_HUMAN (6-979): 0: 1198: 61.46
+	Hs
		856595 EFNA5_HUMAN (1-183): 5.49e-70: 214: 41.03		EPHA5_HUMAN (7-983): 0: 1202: 65.97
+	Hs
		856606 EFNA5_HUMAN (1-183): 5.49e-70: 214: 41.03		EPHA7_HUMAN (6-979): 0: 1198: 61.46
+	Mm
		139053 EFNA5_MOUSE (1-183): 2.06e-69: 213: 40.51		EPHA7_MOUSE (6-979): 0: 1193: 61.77
+	Dr
		47531 A0A8M1Q1X6_DANRE (3-188): 1.44e-75: 228: 40.20		A0A8M9PHF0_DANRE (1-979): 0: 1169: 60.10
+	Hs
		217636 EFNA2_HUMAN (16-195): 1.15e-71: 218: 41.89		EPHA4_HUMAN (8-983): 0: 1164: 62.40
+	Mm
		139052 EFNA5_MOUSE (1-183): 2.06e-69: 213: 40.51		EPHB2_MOUSE (29-981): 0: 1166: 55.90
+	Hs
		856597 EFNA5_HUMAN (1-183): 5.49e-70: 214: 41.03		EPHA4_HUMAN (8-983): 0: 1164: 62.40
+	Hs
		856596 EFNA5_HUMAN (1-183): 5.49e-70: 214: 41.03		EPHB1_HUMAN (28-983): 0: 1162: 55.69
+	Hs
		856630 EFNA5_HUMAN (1-183): 5.49e-70: 214: 41.03		EPHA6_HUMAN (3-980): 0: 1146: 60.16
+	Hs
		595974 EFNA1_HUMAN (1-205): 2.54e-101: 293: 100.00		EPHA2_HUMAN (27-983): 0: 1061: 50.47
+	Hs
		595984 EFNA1_HUMAN (1-205): 2.54e-101: 293: 100.00		EPHB4_HUMAN (17-977): 0: 1027: 47.44
+	Hs
		665459 EFNA5_HUMAN (1-183): 5.49e-70: 214: 41.03		EPHA8_HUMAN (29-982): 0: 1099: 56.57
+	Hs
		665181 EFNA5_HUMAN (1-183): 5.49e-70: 214: 41.03		EPHA2_HUMAN (27-983): 0: 1061: 50.47
+	Mm
		139050 EFNA4_MOUSE (4-161): 5.88e-70: 213: 41.51		EPHA1_MOUSE (25-973): 0: 947: 43.01