HitPredict

Interactor 1: EFNA1 (P20827)
Ephrin-A1 (EPH-related receptor tyrosine kinase ligand 1) (LERK-1) (Immediate early response protein B61) (Tumor necrosis factor alpha-induced protein 4) (TNF alpha-induced protein 4) [Cleaved into: Ephrin-A1, secreted form]
Gene: EFNA1

Interactor 2: EPHB4 (P54760)
Ephrin type-B receptor 4 (EC 2.7.10.1) (Hepatoma transmembrane kinase) (Tyrosine-protein kinase TYRO11)
Gene: EPHB4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36736316
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ephrin~Ephrin_lbd
Common GO terms	GO:0001525 - angiogenesis GO:0005576 - extracellular region GO:0005886 - plasma membrane GO:0007411 - axon guidance GO:0048013 - ephrin receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 205 Hs			1 987
+	Hs
		595976 EFNA1_HUMAN (1-205): 2.54e-101: 293: 100.00		EPHB2_HUMAN (17-974): 0: 1118: 55.64
+	Hs
		595985 EFNA1_HUMAN (1-205): 2.54e-101: 293: 100.00		EPHA4_HUMAN (3-981): 0: 1093: 49.70
+	Hs
		595975 EFNA1_HUMAN (1-205): 2.54e-101: 293: 100.00		EPHA3_HUMAN (13-975): 0: 1080: 48.35
+	Dr
		47532 A0A8M1Q1X6_DANRE (3-188): 1.44e-75: 228: 40.20		Q5ZEW1_DANRE (3-974): 0: 1129: 51.28
+	Mm
		139052 EFNA5_MOUSE (1-183): 2.06e-69: 213: 40.51		EPHB2_MOUSE (17-980): 0: 1120: 55.29
+	Hs
		856596 EFNA5_HUMAN (1-183): 5.49e-70: 214: 41.03		EPHB1_HUMAN (16-975): 0: 1118: 56.55
+	Hs
		217642 EFNA2_HUMAN (16-195): 1.15e-71: 218: 41.89		EPHA7_HUMAN (3-981): 0: 1100: 48.64
+	Dr
		47531 A0A8M1Q1X6_DANRE (3-188): 1.44e-75: 228: 40.20		A0A8M9PHF0_DANRE (1-981): 0: 1090: 47.17
+	Mm
		139053 EFNA5_MOUSE (1-183): 2.06e-69: 213: 40.51		EPHA7_MOUSE (3-981): 0: 1102: 48.94
+	Hs
		856606 EFNA5_HUMAN (1-183): 5.49e-70: 214: 41.03		EPHA7_HUMAN (3-981): 0: 1100: 48.64
+	Hs
		856595 EFNA5_HUMAN (1-183): 5.49e-70: 214: 41.03		EPHA5_HUMAN (1-978): 0: 1099: 47.77
+	Hs
		217636 EFNA2_HUMAN (16-195): 1.15e-71: 218: 41.89		EPHA4_HUMAN (3-981): 0: 1093: 49.70
+	Hs
		595974 EFNA1_HUMAN (1-205): 2.54e-101: 293: 100.00		EPHA2_HUMAN (15-974): 0: 1016: 44.82
+	Hs
		856597 EFNA5_HUMAN (1-183): 5.49e-70: 214: 41.03		EPHA4_HUMAN (3-981): 0: 1093: 49.70
+	Hs
		665382 EFNA5_HUMAN (1-183): 5.49e-70: 214: 41.03		EPHA3_HUMAN (13-975): 0: 1080: 48.35
+	Mm
		139054 EFNA5_MOUSE (1-183): 2.06e-69: 213: 40.51		Q8BRB1_MOUSE (4-975): 0: 1068: 47.45
+	Hs
		856630 EFNA5_HUMAN (1-183): 5.49e-70: 214: 41.03		EPHA6_HUMAN (1-974): 0: 1055: 46.17
+	Hs
		665459 EFNA5_HUMAN (1-183): 5.49e-70: 214: 41.03		EPHA8_HUMAN (17-978): 0: 1019: 44.89
+	Hs
		665181 EFNA5_HUMAN (1-183): 5.49e-70: 214: 41.03		EPHA2_HUMAN (15-974): 0: 1016: 44.82
+	Mm
		139050 EFNA4_MOUSE (4-161): 5.88e-70: 213: 41.51		EPHA1_MOUSE (13-969): 0: 941: 39.22