HitPredict

Interactor 1: FILA (P20930)
Filaggrin
Gene: FLG

Interactor 2: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.50	0.60	0.552

Property	Details
Experiments	21182203, 25604459
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 4061 Hs			1 530
+	Hs
		1125334 FILA2_HUMAN (1661-4000): 4.12e-60: 233: 20.51		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		369752 FILA2_HUMAN (1661-4000): 4.12e-60: 233: 20.51		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		369946 HORN_HUMAN (2054-4025): 1.48e-58: 228: 17.22		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		639034 S100P_HUMAN (1-95): 2.66e-45: 161: 34.74		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		685181 S10AB_HUMAN (2-102): 4.49e-42: 152: 30.69		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		1269345 S10AG_HUMAN (2-97): 1.67e-33: 128: 19.59		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		369283 S10AA_HUMAN (2-100): 1.31e-42: 153: 26.26		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		368808 S10A8_HUMAN (1-95): 1.16e-36: 136: 27.37		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		1269810 CHD7_HUMAN (2674-3252): 7.02e-09: 64.9: 7.69		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		377009 S10A9_HUMAN (1-102): 2.02e-40: 148: 35.92		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Hs
		370607 CHD7_HUMAN (2674-3252): 7.02e-09: 64.9: 7.69		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		377001 S10A8_HUMAN (1-95): 1.16e-36: 136: 27.37		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Hs
		320221 S10AG_HUMAN (2-97): 1.67e-33: 128: 19.59		ERR2_HUMAN (69-499): 5.86e-109: 333: 31.57
+	Hs
		782677 CHD7_HUMAN (2674-3252): 7.02e-09: 64.9: 7.69		HNF4A_HUMAN (94-502): 1.21e-107: 331: 23.30
+	Hs
		377760 CHD7_HUMAN (2674-3252): 7.02e-09: 64.9: 7.69		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Mm
		57773 ARI1A_MOUSE (313-1826): 9.57e-09: 64.2: 8.55		ERR2_MOUSE (69-499): 5.26e-107: 328: 31.11
+	Mm
		57758 ARI1A_MOUSE (313-1826): 9.57e-09: 64.2: 8.55		RARA_MOUSE (52-508): 5.87e-105: 324: 23.58
+	Hs
		487574 HORN_HUMAN (2054-4025): 1.48e-58: 228: 17.22		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		487803 CHD7_HUMAN (2674-3252): 7.02e-09: 64.9: 7.69		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59