Interactor 1: TNFA (P16599)
Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
Gene: Tnf
Interactor 2: MCL1 (Q9Z1P3)
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
Gene: MCL1
Species: Rattus norvegicus
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.33 | 0.60 | 0.445 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 17623297 |
| Identification Methods | pull down |
| Interaction Type | association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0008630 - intrinsic apoptotic signaling pathway in response to DNA damage GO:0043065 - positive regulation of apoptotic process GO:0043066 - negative regulation of apoptotic process GO:0043525 - positive regulation of neuron apoptotic process GO:2001240 - negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| Homologous interactions | 1 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
