Protein: TNFA
Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]

Gene: TNFA, Tnf
Organism: Rattus norvegicus
Interactions: 72
UniProt ID: P16599

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000976 - transcription cis-regulatory region binding
GO:0001666 - response to hypoxia
GO:0001774 - microglial cell activation
GO:0001819 - positive regulation of cytokine production

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

597906

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

20

Small-scale

0.575

High

597946

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

20

Small-scale

0.575

High

64497

A6JI19
Caspase-7

1

13

Small-scale

0.445

High

86927

C0H5Y5
CASP8 and FADD-like apoptosis regulator

1

13

Small-scale

0.445

High

108221

LRP1
Prolow-density lipoprotein receptor-related protein 1

1

1

Small-scale

0.445

High

415086

TPM1
Tropomyosin alpha-1 chain

1

9

Small-scale

0.445

High

472253

A4
Amyloid-beta precursor protein

1

2

Small-scale

0.445

High

547299

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

1

Small-scale

0.445

High

597907

VIME
Vimentin

1

3

Small-scale

0.445

High

597908

CALX
Calnexin

1

2

Small-scale

0.445

High

597911

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C]

1

5

Small-scale

0.445

High

597912

CASP3
Caspase-3

1

13

Small-scale

0.445

High

597913

ACTB
Actin, cytoplasmic 1

1

7

Small-scale

0.445

High

597915

ACTA
Actin, aortic smooth muscle

1

7

Small-scale

0.445

High

597917

ACTG
Actin, cytoplasmic 2

1

7

Small-scale

0.445

High

597918

ACTH
Actin, gamma-enteric smooth muscle

1

7

Small-scale

0.445

High

597919

ACTS
Actin, alpha skeletal muscle

1

7

Small-scale

0.445

High

597923

Q2TVU3
DnaJ homolog subfamily A member 3, mitochondrial

1

2

Small-scale

0.445

High

597927

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

3

Small-scale

0.445

High

597930

Q5XIP0
DnaJ heat shock protein family

1

1

Small-scale

0.445

High

597933

Q63075
Fibrillar collagen NC1 domain-containing protein

1

1

Small-scale

0.445

High

597941

HPBP1
Hsp70-binding protein 1

1

1

Small-scale

0.445

High

597942

Q6MG72
[histone H3]-lysine(9) N-methyltransferase

1

3

Small-scale

0.445

High

597944

SSPO
SCO-spondin

1

4

Small-scale

0.445

High

597945

Q7TS60
Bcl-2-like protein 2

1

1

Small-scale

0.445

High

597948

CASPC
Caspase-12

1

13

Small-scale

0.445

High

597953

BID
BH3-interacting domain death agonist

1

1

Small-scale

0.445

High

597954

MEGF8
Multiple epidermal growth factor-like domains protein 8

1

3

Small-scale

0.445

High

597955

Q9WU10
Protocadherin

1

1

Small-scale

0.445

High

597956

Q9WUH9
Fibrillin-2

1

2

Small-scale

0.445

High

597958

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog

1

1

Small-scale

0.445

High

93249

D4A4X6
ADAMTS-like protein 2

1

0

Small-scale

0.426

High

267194

LG3BP
Galectin-3-binding protein

1

0

Small-scale

0.426

High

569034

CO3A1

1

0

Small-scale

0.426

High

597909

MT3
Metallothionein-3

1

0

Small-scale

0.426

High

597910

LDHB
L-lactate dehydrogenase B chain

1

0

Small-scale

0.426

High

597920

ZEP2
Human immunodeficiency virus type I enhancer-binding protein 2 homolog

1

0

Small-scale

0.426

High

597921

AP180
Clathrin coat assembly protein AP180

1

0

Small-scale

0.426

High

597922

ATPO
ATP synthase peripheral stalk subunit OSCP, mitochondrial

1

0

Small-scale

0.426

High

597924

Q3KR98
Importin subunit alpha

1

0

Small-scale

0.426

High

597928

Q5XIC5
Pleckstrin homology domain containing A3

1

0

Small-scale

0.426

High

597929

CPIN1
Anamorsin

1

0

Small-scale

0.426

High

597931

Q62677
Alpha-1 collagen type IV

1

0

Small-scale

0.426

High

597934

Q63122
Alpha-3 type IV collagen

1

0

Small-scale

0.426

High

597939

Q6AY44
Mucolipin 3

1

0

Small-scale

0.426

High

597951

PLCE1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

1

0

Small-scale

0.426

High

64500

A6K2U1
26S proteasome non-ATPase regulatory subunit 4

1

1

Small-scale

0.407

High

97312

E9PTR4
Ubiquitin associated protein 2-like

1

1

Small-scale

0.407

High

383218

RLA2
Large ribosomal subunit protein P2

1

1

Small-scale

0.407

High

597914

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

2

Small-scale

0.407

High

597932

Q62772
Tenascin-X

1

1

Small-scale

0.407

High

597935

Q63607
Alpha-tropomyosin 3

1

9

Small-scale

0.407

High

597936

TPM3
Tropomyosin alpha-3 chain

1

9

Small-scale

0.407

High

597937

PRDX1
Peroxiredoxin-1

1

1

Small-scale

0.407

High

597938

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

3

Small-scale

0.407

High

597940

Q6AZ25
Tropomyosin 1

1

9

Small-scale

0.407

High

597947

Q91XN6
Tropomyosin 1

1

9

Small-scale

0.407

High

597949

Q923Z2
Tropomyosin 1, alpha, isoform CRA_a

1

9

Small-scale

0.407

High

597950

Q99M88
Caspase-9 CTD isoform

1

13

Small-scale

0.407

High

50751

A1L132
DNA-(apurinic or apyrimidinic site) endonuclease

1

0

Small-scale

0.232

Low

64481

A6HNA2
26S proteasome regulatory subunit 6A

1

0

Small-scale

0.232

Low

93129

D3ZW60
TOG array regulator of axonemal microtubules protein 1

1

0

Small-scale

0.232

Low

204721

GBB4
Guanine nucleotide-binding protein subunit beta-4

1

0

Small-scale

0.232

Low

204723

O35359
Guanine nucleotide-binding protein subunit gamma

1

0

Small-scale

0.232

Low

204952

F263
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3

1

0

Small-scale

0.232

Low

408213

MT2
Metallothionein-2

1

0

Small-scale

0.232

Low

597916

RL8
Large ribosomal subunit protein uL2

1

0

Small-scale

0.232

Low

597925

Q4KLH1
Ascc3l1 protein

1

0

Small-scale

0.232

Low

597926

BAG5
BAG family molecular chaperone regulator 5

1

0

Small-scale

0.232

Low

597943

Q6UN82
Protein SET

1

0

Small-scale

0.232

Low

597952

Q99PU6
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

1

0

Small-scale

0.232

Low

597957

Q9Z0Z2
Interleukin 12 receptor beta1 subunit

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025