HitPredict

Interactor 1: FLNA (P21333)
Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)
Gene: FLNA

Interactor 2: DRD3 (P35462)
D(3) dopamine receptor (Dopamine D3 receptor)
Gene: DRD3

Species: Homo sapiens

Source: dip

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	0.60	0.586

Property	Details
Experiments	11911837, 11320256
Identification Methods	two hybrid, coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007195 - adenylate cyclase-inhibiting dopamine receptor signaling pathway
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 2647 Hs			1 400
+	Hs
		537253 FLNA_HUMAN (1-2647): 0: 2776: 100.00		DRD2_HUMAN (9-400): 1.05e-75: 243: 44.37
+	Hs
		428914 FLNA_HUMAN (1-2647): 0: 2776: 100.00		ADRB2_HUMAN (1-399): 2.19e-56: 192: 23.33
+	Hs
		722936 FLNC_HUMAN (32-2647): 0: 1432: 35.96		ADA1A_HUMAN (7-399): 5.81e-74: 239: 29.29
+	Hs
		626688 FLNC_HUMAN (32-2647): 0: 1432: 35.96		ADA1D_HUMAN (14-394): 3.91e-70: 232: 30.47
+	Hs
		723009 FLNC_HUMAN (32-2647): 0: 1432: 35.96		ADA1B_HUMAN (10-400): 1.48e-69: 229: 29.65
+	Hs
		656944 ACTN2_HUMAN (6-459): 1.76e-121: 410: 23.62		5HT1B_HUMAN (2-399): 1.33e-63: 210: 27.54