HitPredict

Interactor 1: FLNA (P21333)
Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)
Gene: FLNA

Interactor 2: CC141 (Q6ZP82)
Coiled-coil domain-containing protein 141 (Coiled-coil protein associated with myosin II and DISC1)
Gene: CCDC141

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	32814053
Identification Methods	two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CH~Spectrin
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2647 Hs			1 1530
+	Hs
		164566 FLNA_HUMAN (1-2647): 0: 2776: 100.00		SPTN2_HUMAN (105-1195): 1.39e-42: 173: 12.01
+	Hs
		598070 FLNA_HUMAN (1-2647): 0: 2776: 100.00		SPTB2_HUMAN (103-1235): 4e-38: 159: 12.52
+	Hs
		597985 FLNA_HUMAN (1-2647): 0: 2776: 100.00		MYH9_HUMAN (316-1357): 1.13e-29: 131: 8.36
+	Hs
		597987 FLNA_HUMAN (1-2647): 0: 2776: 100.00		MYH11_HUMAN (390-1407): 5.57e-29: 129: 9.72
+	Hs
		279838 FLNA_HUMAN (1-2647): 0: 2776: 100.00		TRIO_HUMAN (1254-1501): 6.29e-20: 99.4: 16.80
+	Hs
		598108 FLNA_HUMAN (1-2647): 0: 2776: 100.00		SPTN1_HUMAN (539-1276): 8.81e-11: 69.2: 11.45
+	Hs
		598253 FLNA_HUMAN (1-2647): 0: 2776: 100.00		TITIN_HUMAN (1404-1499): 4.94e-10: 67.1: 26.04
+	Hs
		261212 FLNB_HUMAN (28-2647): 0: 2710: 69.63		MYH9_HUMAN (316-1357): 1.13e-29: 131: 8.36
+	Hs
		164603 SPTB2_HUMAN (22-460): 2.2e-118: 423: 24.62		SPTN2_HUMAN (105-1195): 1.39e-42: 173: 12.01
+	Ce
		103420 G5EG85_CAEEL (8-460): 2.81e-117: 419: 22.41		G4S034_CAEEL (41-1167): 1.58e-40: 167: 10.59
+	Hs
		963291 SPTB2_HUMAN (22-460): 2.2e-118: 423: 24.62		SPTB2_HUMAN (103-1235): 4e-38: 159: 12.52
+	Dm
		527092 SPTCB_DROME (23-460): 1.43e-116: 417: 23.58		SPTCA_DROME (325-1149): 1.15e-36: 154: 11.59
+	Hs
		724781 SPTB2_HUMAN (22-460): 2.2e-118: 423: 24.62		MYH9_HUMAN (316-1357): 1.13e-29: 131: 8.36
+	Mm
		57853 SPTB2_MOUSE (22-460): 2.2e-118: 423: 24.62		KALRN_MOUSE (860-1519): 3.32e-21: 103: 11.89
+	Hs
		360638 SPTB2_HUMAN (22-460): 2.2e-118: 423: 24.62		SPTA1_HUMAN (43-336): 4.12e-14: 80.2: 17.06
+	Hs
		360607 SPTB1_HUMAN (2-460): 2.89e-117: 419: 23.57		SPTA1_HUMAN (43-336): 4.12e-14: 80.2: 17.06
+	Rn
		555258 Q6XD99_RAT (22-460): 2.17e-118: 423: 24.62		SPTN1_RAT (539-1276): 1.14e-10: 69.2: 11.32
+	Hs
		963320 SPTB2_HUMAN (22-460): 2.2e-118: 423: 24.62		SPTN1_HUMAN (539-1276): 8.81e-11: 69.2: 11.45
+	Hs
		506818 SPTB1_HUMAN (2-460): 2.89e-117: 419: 23.57		SPTN1_HUMAN (539-1276): 8.81e-11: 69.2: 11.45
+	Hs
		725681 ACTN2_HUMAN (6-459): 1.76e-121: 410: 23.62		TITIN_HUMAN (1404-1499): 4.94e-10: 67.1: 26.04