Protein: AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) (SR Ca(2+)-ATPase 2) (EC 7.2.2.10) (Calcium pump 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase)

Gene: AT2A2, Atp2a2
Organism: Mus musculus
Interactions: 42
UniProt ID: O55143

Gene Ontology (top 5):
GO:0000045 - autophagosome assembly
GO:0002026 - regulation of the force of heart contraction
GO:0005246 - calcium channel regulator activity
GO:0005388 - P-type calcium transporter activity
GO:0005509 - calcium ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

237227

PPLA
Phospholamban

3

3

Small-scale

0.805

High

109179

AT2B1
Plasma membrane calcium-transporting ATPase 1

1

16

Small-scale

0.618

High

237214

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

15

High-throughput

0.618

High

237236

NEB2
Neurabin-2

2

9

High-throughput

0.584

High

237233

STING
Stimulator of interferon genes protein

2

4

High-throughput

0.571

High

237228

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

2

1

High-throughput

0.521

High

95471

PIEZ1
Piezo-type mechanosensitive ion channel component 1

1

4

Small-scale

0.515

High

237234

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

3

High-throughput

0.500

High

97336

PRRT2
Proline-rich transmembrane protein 2

1

5

High-throughput

0.479

High

108362

G3X9H5
Huntingtin

1

4

High-throughput

0.479

High

237216

TAU
Microtubule-associated protein tau

1

14

High-throughput

0.479

High

237230

NMDE2
Glutamate receptor ionotropic, NMDA 2B

1

3

High-throughput

0.479

High

237232

TF65
Transcription factor p65

1

3

Small-scale

0.479

High

237238

TRPV1
Transient receptor potential cation channel subfamily V member 1

1

5

High-throughput

0.479

High

237239

FACD2
Fanconi anemia group D2 protein homolog

1

5

High-throughput

0.479

High

237241

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

1

High-throughput

0.479

High

237243

FNDC5
Fibronectin type III domain-containing protein 5

1

2

High-throughput

0.479

High

237248

TLR9
Toll-like receptor 9

1

3

Small-scale

0.479

High

237225

ATX1
Ataxin-1

1

5

High-throughput

0.470

High

237217

CALR
Calreticulin

1

7

High-throughput

0.445

High

237222

CALX
Calnexin

1

7

High-throughput

0.445

High

237223

CAV3
Caveolin-3

1

4

High-throughput

0.445

High

237231

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

9

High-throughput

0.445

High

237244

TMX1
Thioredoxin-related transmembrane protein 1

1

3

High-throughput

0.445

High

147680

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

3

High-throughput

0.437

High

237215

CFAD
Complement factor D

1

11

High-throughput

0.437

High

237218

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

6

High-throughput

0.437

High

237219

TWST1
Twist-related protein 1

1

3

High-throughput

0.437

High

237220

SSR3
Somatostatin receptor type 3

1

20

High-throughput

0.437

High

237224

TIA1
Cytotoxic granule associated RNA binding protein TIA1

1

1

High-throughput

0.437

High

237226

UBP25
Ubiquitin carboxyl-terminal hydrolase 25

1

7

Small-scale

0.437

High

237237

SPOP
Speckle-type POZ protein

1

2

High-throughput

0.437

High

237240

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

6

High-throughput

0.437

High

237245

PODO
Podocin

1

6

Small-scale

0.437

High

237246

LNX2
Ligand of Numb protein X 2

1

6

High-throughput

0.437

High

237247

EED
Polycomb protein EED

1

5

High-throughput

0.437

High

92704

SELN
Selenoprotein N

1

0

High-throughput

0.426

High

237221

RAB5C
Ras-related protein Rab-5C

1

10

High-throughput

0.407

High

237235

Q6AXH7
Histone-lysine N-methyltransferase EZH2

1

4

High-throughput

0.407

High

237229

RGS14
Regulator of G-protein signaling 14

1

0

High-throughput

0.249

Low

237242

MT21E
Protein-lysine methyltransferase METTL21E

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025