HitPredict

Interactor 1: PRS37 (A4D1T9)
Probable inactive serine protease 37 (Probable inactive trypsin-X2)
Gene: PRSS37

Interactor 2: LRP6 (O75581)
Low-density lipoprotein receptor-related protein 6 (LRP-6)
Gene: LRP6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	FXa_inhibition~Trypsin, Ldl_recept_a~Trypsin
Common GO terms	GO:0005576 - extracellular region
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 235 Hs			1 1613
+	Hs
		270263 KLK2_HUMAN (12-233): 4.23e-98: 288: 24.79		LRP6_HUMAN (1-1613): 0: 1791: 100.00
+	Hs
		270327 KLK15_HUMAN (19-233): 1.47e-97: 286: 27.83		LRP6_HUMAN (1-1613): 0: 1791: 100.00
+	Hs
		270253 KLK3_HUMAN (14-232): 3.6e-94: 278: 23.40		LRP6_HUMAN (1-1613): 0: 1791: 100.00
+	Hs
		270350 KLK5_HUMAN (13-233): 3.7e-92: 274: 24.12		LRP6_HUMAN (1-1613): 0: 1791: 100.00
+	Hs
		270267 CMA1_HUMAN (15-233): 6.08e-89: 264: 24.23		LRP6_HUMAN (1-1613): 0: 1791: 100.00
+	Hs
		270254 CATG_HUMAN (15-234): 3.54e-87: 260: 25.11		LRP6_HUMAN (1-1613): 0: 1791: 100.00
+	Hs
		59821 PRS37_HUMAN (1-235): 5.5e-111: 319: 100.00		LRP5_HUMAN (15-1613): 0: 1642: 69.70
+	Hs
		258345 KLK15_HUMAN (19-233): 1.47e-97: 286: 27.83		LRP5_HUMAN (15-1613): 0: 1642: 69.70
+	Hs
		258288 KLK3_HUMAN (14-232): 3.6e-94: 278: 23.40		LRP5_HUMAN (15-1613): 0: 1642: 69.70
+	Hs
		258362 KLK5_HUMAN (13-233): 3.7e-92: 274: 24.12		LRP5_HUMAN (15-1613): 0: 1642: 69.70
+	Hs
		351098 TMPSD_HUMAN (8-233): 8.42e-94: 287: 18.78		LDLR_HUMAN (1319-1612): 1.89e-23: 110: 8.70
+	Hs
		351104 KLK15_HUMAN (19-233): 1.47e-97: 286: 27.83		LDLR_HUMAN (1319-1612): 1.89e-23: 110: 8.70
+	Hs
		351117 KLK5_HUMAN (13-233): 3.7e-92: 274: 24.12		LDLR_HUMAN (1319-1612): 1.89e-23: 110: 8.70
+	Hs
		351049 CMA1_HUMAN (15-233): 6.08e-89: 264: 24.23		LDLR_HUMAN (1319-1612): 1.89e-23: 110: 8.70
+	Hs
		351038 CATG_HUMAN (15-234): 3.54e-87: 260: 25.11		LDLR_HUMAN (1319-1612): 1.89e-23: 110: 8.70
+	Hs
		621380 CMA1_HUMAN (15-233): 6.08e-89: 264: 24.23		SORL_HUMAN (1169-1391): 5.2e-22: 106: 19.56
+	Hs
		439352 CATG_HUMAN (15-234): 3.54e-87: 260: 25.11		SORL_HUMAN (1169-1391): 5.2e-22: 106: 19.56
+	Hs
		371465 KLKB1_HUMAN (13-234): 8.59e-95: 291: 21.16		NID2_HUMAN (542-627): 4.1e-10: 67: 21.59
+	Mm
		371501 CFAD_MOUSE (28-230): 6.54e-14: 70.9: 27.52		NID1_MOUSE (1437-1606): 5.28e-12: 73.2: 7.22
+	Mm
		372321 CFAD_MOUSE (28-230): 6.54e-14: 70.9: 27.52		LRP1_MOUSE (1442-1610): 7.22e-09: 63.1: 3.91