HitPredict

Interactor 1: FLNA (P21333)
Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)
Gene: FLNA

Interactor 2: M3K2 (Q9Y2U5)
Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2)
Gene: MAP3K2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	30021884
Identification Methods	proximity labelling technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 2647 Hs			1 619
+	Hs
		598291 FLNA_HUMAN (1-2647): 0: 2776: 100.00		M3K3_HUMAN (1-615): 1.07e-179: 524: 64.59
+	Hs
		598093 FLNA_HUMAN (1-2647): 0: 2776: 100.00		PAK1_HUMAN (96-617): 8.05e-126: 383: 23.83
+	Hs
		598381 FLNA_HUMAN (1-2647): 0: 2776: 100.00		AKT3_HUMAN (292-616): 4.97e-125: 379: 24.47
+	Hs
		598097 FLNA_HUMAN (1-2647): 0: 2776: 100.00		M3K1_HUMAN (351-613): 5.82e-51: 192: 42.13
+	Hs
		261250 FLNB_HUMAN (28-2647): 0: 2710: 69.63		M3K1_HUMAN (351-613): 5.82e-51: 192: 42.13
+	Hs
		261350 FLNB_HUMAN (28-2647): 0: 2710: 69.63		M3K4_HUMAN (356-616): 2.34e-47: 181: 39.10
+	Hs
		211696 ACTN4_HUMAN (23-382): 4.2e-112: 383: 27.01		M3K2_HUMAN (1-619): 0: 590: 100.00
+	Hs
		963402 SPTB2_HUMAN (22-460): 2.2e-118: 423: 24.62		M3K3_HUMAN (1-615): 1.07e-179: 524: 64.59
+	Hs
		211649 ACTN4_HUMAN (23-382): 4.2e-112: 383: 27.01		M3K3_HUMAN (1-615): 1.07e-179: 524: 64.59
+	Hs
		521533 ACTN1_HUMAN (20-459): 1.14e-118: 402: 23.53		M3K1_HUMAN (351-613): 5.82e-51: 192: 42.13