Protein: KPRA
Phosphoribosyl pyrophosphate synthase-associated protein 1 (PRPP synthase-associated protein 1) (39 kDa phosphoribosypyrophosphate synthase-associated protein) (PAP39)

Gene: KPRA, PRPSAP1
Organism: Homo sapiens
Interactions: 103
UniProt ID: Q14558

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0004857 - enzyme inhibitor activity
GO:0005737 - cytoplasm
GO:0006015 - 5-phosphoribose 1-diphosphate biosynthetic process
GO:0006139 - nucleobase-containing compound metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

954469

PRPS1
Ribose-phosphate pyrophosphokinase 1

14

17

Small-scale

0.985

High

549586

PRPS2
Ribose-phosphate pyrophosphokinase 2

8

17

Small-scale

0.972

High

240089

KPRB
Phosphoribosyl pyrophosphate synthase-associated protein 2

6

16

High-throughput

0.944

High

1127954

KPRA
Phosphoribosyl pyrophosphate synthase-associated protein 1

4

14

High-throughput

0.904

High

1128001

NS1BP
Influenza virus NS1A-binding protein

3

4

High-throughput

0.667

High

1127967

DAAF8
Dynein axonemal assembly factor 8

2

0

High-throughput

0.602

High

971525

1433E
14-3-3 protein epsilon

2

3

Small-scale

0.601

High

241681

PRKN
E3 ubiquitin-protein ligase parkin

2

7

High-throughput

0.584

High

193272

SOCS1
Suppressor of cytokine signaling 1

2

14

High-throughput

0.571

High

249751

DOK2
Docking protein 2

2

4

High-throughput

0.571

High

277927

SH3L1
Adapter SH3BGRL

2

3

High-throughput

0.571

High

584540

VAV
Proto-oncogene vav

2

3

High-throughput

0.571

High

593998

NCK1
SH2/SH3 adapter protein NCK1

2

14

High-throughput

0.571

High

603270

KPCA
Protein kinase C alpha type

2

10

High-throughput

0.571

High

631220

RAB5A
Ras-related protein Rab-5A

2

3

High-throughput

0.571

High

635718

RASA1
Ras GTPase-activating protein 1

2

3

High-throughput

0.571

High

853679

MK08
Mitogen-activated protein kinase 8

2

5

High-throughput

0.571

High

955167

CDC42
Cell division control protein 42 homolog

2

8

High-throughput

0.571

High

988368

RAC1
Ras-related C3 botulinum toxin substrate 1

2

7

High-throughput

0.571

High

1050793

PTN12
Tyrosine-protein phosphatase non-receptor type 12

2

3

High-throughput

0.571

High

1096436

PAK1
Serine/threonine-protein kinase PAK 1

2

4

High-throughput

0.571

High

1097132

MK07
Mitogen-activated protein kinase 7

2

9

High-throughput

0.571

High

944383

SYJ2B
Synaptojanin-2-binding protein

2

1

High-throughput

0.549

High

1127966

HOME1
Homer protein homolog 1

1

1

High-throughput

0.536

High

1127975

CSN5
COP9 signalosome complex subunit 5

1

7

High-throughput

0.536

High

1127982

TRIM7
E3 ubiquitin-protein ligase TRIM7

1

1

High-throughput

0.536

High

1127999

MB212
Protein mab-21-like 2

1

1

High-throughput

0.536

High

424660

KPCG
Protein kinase C gamma type

2

11

High-throughput

0.521

High

440559

FYN
Tyrosine-protein kinase Fyn

2

11

High-throughput

0.521

High

473418

HCK
Tyrosine-protein kinase HCK

2

11

High-throughput

0.521

High

486693

FGR
Tyrosine-protein kinase Fgr

2

11

High-throughput

0.521

High

702348

ELK4
ETS domain-containing protein Elk-4

2

5

High-throughput

0.521

High

878460

PAXI
Paxillin

2

5

High-throughput

0.521

High

905745

CAV2
Caveolin-2

2

7

High-throughput

0.521

High

1041064

CAV1
Caveolin-1

2

7

High-throughput

0.521

High

1127956

KPCD1
Serine/threonine-protein kinase D1

2

14

High-throughput

0.521

High

1127968

ABI1
Abl interactor 1

2

3

High-throughput

0.521

High

1127971

SH2D3
SH2 domain-containing protein 3C

2

16

High-throughput

0.521

High

244253

NUAK1
NUAK family SNF1-like kinase 1

1

5

High-throughput

0.515

High

277357

TP4A3
Protein tyrosine phosphatase type IVA 3

1

2

High-throughput

0.515

High

445178

S10A6
Protein S100-A6

1

0

High-throughput

0.513

High

1127997

RPGF2
Rap guanine nucleotide exchange factor 2

1

0

High-throughput

0.513

High

1127987

PKHF2
Pleckstrin homology domain-containing family F member 2

1

1

High-throughput

0.494

High

286984

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

0

High-throughput

0.493

High

335838

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2

1

0

High-throughput

0.493

High

1005425

SERB
Phosphoserine phosphatase

1

0

High-throughput

0.493

High

1104397

ILK
Scaffold protein ILK

1

0

High-throughput

0.493

High

177219

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

1

1

High-throughput

0.489

High

487312

PARP1
Poly [ADP-ribose] polymerase 1

1

4

High-throughput

0.489

High

946306

NXPH1
Neurexophilin-1

1

1

High-throughput

0.489

High

1127972

ANR44
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B

1

1

High-throughput

0.489

High

1127974

F174A
Membrane protein FAM174A

1

1

High-throughput

0.489

High

703587

MK01
Mitogen-activated protein kinase 1

1

5

High-throughput

0.481

High

993569

UBC9
SUMO-conjugating enzyme UBC9

1

4

High-throughput

0.481

High

172813

XPO1
Exportin-1

1

3

High-throughput

0.479

High

293687

CD123
Translation initiation factor eIF2 assembly protein

1

3

High-throughput

0.479

High

319763

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.479

High

535059

BIP
Endoplasmic reticulum chaperone BiP

1

2

High-throughput

0.479

High

766552

PHB1
Prohibitin 1

1

1

High-throughput

0.479

High

830733

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

869035

TISD
mRNA decay activator protein ZFP36L2

1

3

High-throughput

0.479

High

1127960

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.479

High

1127964

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

3

High-throughput

0.479

High

1127965

LYRIC
Protein LYRIC

1

1

Small-scale

0.479

High

1127979

CI072
Guanine nucleotide exchange factor C9orf72

1

2

High-throughput

0.479

High

1127981

ANM1
Protein arginine N-methyltransferase 1

1

2

High-throughput

0.479

High

1127983

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

2

High-throughput

0.479

High

1127985

PKHA4
Pleckstrin homology domain-containing family A member 4

1

8

High-throughput

0.479

High

1127989

BRD7
Bromodomain-containing protein 7

1

2

High-throughput

0.479

High

1127991

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

1127993

TNIK
TRAF2 and NCK-interacting protein kinase

1

3

High-throughput

0.479

High

1127996

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

5

Small-scale

0.479

High

1127998

TRAF6
TNF receptor-associated factor 6

1

1

High-throughput

0.479

High

1127988

LFG4
Protein lifeguard 4

1

1

High-throughput

0.470

High

1127963

Q7KZS0
SUMO-conjugating enzyme UBC9

1

4

High-throughput

0.470

High

1127957

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.458

High

1127976

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

1127980

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.458

High

294704

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

1

High-throughput

0.445

High

354699

PAK4
Serine/threonine-protein kinase PAK 4

1

5

High-throughput

0.445

High

1127994

DD19B
ATP-dependent RNA helicase DDX19B

1

0

High-throughput

0.438

High

964948

WDR5
WD repeat-containing protein 5

1

1

High-throughput

0.437

High

970495

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.437

High

1099887

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.437

High

1127955

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

4

High-throughput

0.437

High

1127959

EMC4
ER membrane protein complex subunit 4

1

3

High-throughput

0.437

High

1127961

ASB18
Ankyrin repeat and SOCS box protein 18

1

5

High-throughput

0.437

High

1127962

PAXI1
PAX-interacting protein 1

1

1

High-throughput

0.437

High

1127970

FBXL6
F-box/LRR-repeat protein 6

1

1

High-throughput

0.437

High

1127973

TIP
T-cell immunomodulatory protein

1

1

High-throughput

0.437

High

1127978

ASB9
Ankyrin repeat and SOCS box protein 9

1

6

High-throughput

0.437

High

1127986

SFR19
Splicing factor, arginine/serine-rich 19

1

1

High-throughput

0.437

High

1127990

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

2

High-throughput

0.437

High

1127992

FBW1B
F-box/WD repeat-containing protein 11

1

2

High-throughput

0.437

High

429887

JUN
Transcription factor Jun

1

4

High-throughput

0.407

High

1127977

MGN2
Protein mago nashi homolog 2

2

0

High-throughput

0.316

High

1128000

CAN7
Calpain-7

2

0

High-throughput

0.316

High

608267

EGLN
Endoglin

1

0

High-throughput

0.279

Low

1127984

SMG9
Nonsense-mediated mRNA decay factor SMG9

1

0

High-throughput

0.279

Low

1127995

PP6R1
Serine/threonine-protein phosphatase 6 regulatory subunit 1

1

0

High-throughput

0.279

Low

1127958

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

1127969

PLD6
Mitochondrial cardiolipin hydrolase

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025