Interactor 1: RIR1 (P21524)
Ribonucleoside-diphosphate reductase large chain 1 (EC 1.17.4.1) (Ribonucleotide reductase R1 subunit 1) (Ribonucleotide reductase large subunit 1)
Gene: RNR1

Interactor 2: RIR4 (P49723)
Ribonucleoside-diphosphate reductase small chain 2 (EC 1.17.4.1) (Ribonucleotide reductase R2 subunit 2) (Ribonucleotide reductase small subunit 2)
Gene: RNR4

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.60 1.00 0.777

The method score is based on:

Property Details
Experiments 16537480, 37968396
Identification Methods x-ray crystallography, affinity chromatography technology
Interaction Type direct interaction, association, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains ATP-cone~Ribonuc_red_sm, Ribonuc_red_lgC~Ribonuc_red_sm
Common GO terms GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005971 - ribonucleoside-diphosphate reductase complex
GO:0009263 - deoxyribonucleotide biosynthetic process
Homologous interactions 13

Homologous interactions

Color coding for hit scores

1 888
Sc

1 345
+ Sc
+ Sc
+ Sp
+ Mm
+ Hs
+ Hs
+ Vv
+ Ec
+ Hh
+ Hh
+ Hh
+ Ha
+ Mp

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Last updated: 15 Jul 2024