HitPredict

Interactor 1: SH321 (A4FU49)
SH3 domain-containing protein 21
Gene: SH3D21

Interactor 2: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.53	0.60	0.565

Property	Details
Experiments	unassigned2173, 20029029
Identification Methods	ubiquitin reconstruction
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 640 Hs			1 1210
+	Mm
		964571 ARHG7_MOUSE (26-598): 1.44e-45: 175: 14.50		EGFR_MOUSE (1-1210): 0: 1258: 90.35
+	Hs
		338419 ARHG7_HUMAN (26-604): 1e-49: 187: 13.67		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		338817 SH3K1_HUMAN (5-620): 2.24e-38: 152: 15.12		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		338201 BCAR1_HUMAN (70-608): 3.98e-32: 134: 14.81		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		338903 SH3G2_HUMAN (3-127): 3.5e-29: 121: 26.40		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		338633 SH3R1_HUMAN (1-639): 2.67e-27: 119: 9.93		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		338904 SH3G3_HUMAN (2-129): 3.24e-24: 106: 24.22		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		383923 SH3K1_HUMAN (5-620): 2.24e-38: 152: 15.12		ERBB2_HUMAN (5-1200): 0: 1111: 48.49
+	Hs
		383714 BCAR1_HUMAN (70-608): 3.98e-32: 134: 14.81		ERBB2_HUMAN (5-1200): 0: 1111: 48.49
+	Hs
		665643 SH3K1_HUMAN (5-620): 2.24e-38: 152: 15.12		EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76
+	Hs
		434276 SH3G2_HUMAN (3-127): 3.5e-29: 121: 26.40		RET_HUMAN (420-1058): 5.61e-129: 425: 22.69
+	Hs
		253317 SRGP2_HUMAN (1-439): 1.37e-35: 146: 14.09		EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76
+	Hs
		253355 SRGP2_HUMAN (1-439): 1.37e-35: 146: 14.09		EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23
+	Hs
		983649 SH3K1_HUMAN (5-620): 2.24e-38: 152: 15.12		FAK1_HUMAN (716-991): 1.58e-53: 206: 37.68
+	Mm
		222876 SRGP2_MOUSE (1-439): 3.53e-36: 147: 13.67		ACK1_MOUSE (691-967): 2.4e-53: 206: 38.87
+	Hs
		882261 BCAR1_HUMAN (70-608): 3.98e-32: 134: 14.81		ACK1_HUMAN (691-967): 4.54e-56: 214: 39.58
+	Rn
		192646 BCAR1_RAT (10-608): 1.98e-32: 136: 13.68		FAK1_RAT (716-991): 6.81e-54: 207: 37.68
+	Hs
		882256 BCAR1_HUMAN (70-608): 3.98e-32: 134: 14.81		FAK1_HUMAN (716-991): 1.58e-53: 206: 37.68
+	Mm
		710139 BCAR1_MOUSE (70-608): 2.41e-31: 132: 13.07		FAK1_MOUSE (716-991): 5.99e-54: 207: 37.68
+	Hs
		435682 SH3R1_HUMAN (1-639): 2.67e-27: 119: 9.93		IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47