Protein: GARS
Glycine--tRNA ligase (EC 6.1.1.14) (Diadenosine tetraphosphate synthetase) (Ap4A synthetase) (EC 2.7.7.-) (Glycyl-tRNA synthetase) (GlyRS) (Glycyl-tRNA synthetase 1)

Gene: GARS, GARS1
Organism: Homo sapiens
Interactions: 159
UniProt ID: P41250

Gene Ontology (top 5):
GO:0004081 - bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity
GO:0004820 - glycine-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

782864

GARS
Glycine--tRNA ligase

2

1

Small-scale

0.812

High

572882

PRS6A
26S proteasome regulatory subunit 6A

3

2

High-throughput

0.667

High

226748

PRKN
E3 ubiquitin-protein ligase parkin

3

1

High-throughput

0.640

High

346142

MYC
Myc proto-oncogene protein

3

1

High-throughput

0.640

High

388279

HSPB1
Heat shock protein beta-1

2

1

Small-scale

0.614

High

782963

HDAC6
Histone deacetylase 6

2

1

Small-scale

0.601

High

782882

UBC12
NEDD8-conjugating enzyme Ubc12

2

0

Small-scale

0.598

High

322286

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

0

High-throughput

0.559

High

503597

HSP7C
Heat shock cognate 71 kDa protein

2

0

High-throughput

0.559

High

782879

TERA
Transitional endoplasmic reticulum ATPase

2

0

High-throughput

0.559

High

669296

EF1D
Elongation factor 1-delta

1

0

Small-scale

0.549

High

782868

MK08
Mitogen-activated protein kinase 8

1

1

High-throughput

0.541

High

782893

M3K10
Mitogen-activated protein kinase kinase kinase 10

1

1

High-throughput

0.541

High

782899

ULA1
NEDD8-activating enzyme E1 regulatory subunit

1

0

Small-scale

0.537

High

782909

NEDD8
NEDD8

1

0

Small-scale

0.537

High

201255

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

1

High-throughput

0.536

High

434994

SP1
Transcription factor Sp1

1

1

High-throughput

0.536

High

782908

STK11
Serine/threonine-protein kinase STK11

1

1

High-throughput

0.536

High

782967

PACN2
Protein kinase C and casein kinase substrate in neurons protein 2

1

2

High-throughput

0.536

High

726071

BASI
Basigin

1

1

High-throughput

0.515

High

782911

BATF
Basic leucine zipper transcriptional factor ATF-like

1

1

High-throughput

0.515

High

782947

KLF6
Krueppel-like factor 6

1

1

High-throughput

0.515

High

155788

UN13B
Protein unc-13 homolog B

1

0

High-throughput

0.513

High

506809

SPTB1
Spectrin beta chain, erythrocytic

1

0

High-throughput

0.513

High

528715

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.513

High

782871

NEST
Nestin

1

0

High-throughput

0.513

High

782877

PEX5
Peroxisomal targeting signal 1 receptor

1

0

High-throughput

0.513

High

782889

MAP1A
Microtubule-associated protein 1A

1

0

High-throughput

0.513

High

782907

MYLK
Myosin light chain kinase, smooth muscle

1

0

High-throughput

0.513

High

782938

CUL5
Cullin-5

1

0

High-throughput

0.513

High

782939

ZN622
Cytoplasmic 60S subunit biogenesis factor ZNF622

1

0

High-throughput

0.513

High

782946

SCYL1
N-terminal kinase-like protein

1

0

High-throughput

0.513

High

782974

SNX9
Sorting nexin-9

1

0

High-throughput

0.513

High

782910

HSPB2
Heat shock protein beta-2

1

1

High-throughput

0.508

High

782964

DUX4
Double homeobox protein 4

1

0

High-throughput

0.494

High

782949

SPAG8
Sperm-associated antigen 8

1

0

High-throughput

0.493

High

782968

CSN3
COP9 signalosome complex subunit 3

1

0

High-throughput

0.493

High

782865

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

2

Small-scale

0.481

High

294479

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.479

High

379093

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

569330

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

782869

IF2M
Translation initiation factor IF-2, mitochondrial

1

1

High-throughput

0.479

High

782873

EFTU
Elongation factor Tu, mitochondrial

1

1

High-throughput

0.479

High

782876

GSK3B
Glycogen synthase kinase-3 beta

1

1

High-throughput

0.479

High

782878

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

1

High-throughput

0.479

High

782880

HDAC4
Histone deacetylase 4

1

1

High-throughput

0.479

High

782886

1433Z
14-3-3 protein zeta/delta

1

1

High-throughput

0.479

High

782896

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

2

High-throughput

0.479

High

782901

DX39B
Spliceosome RNA helicase DDX39B

1

2

Small-scale

0.479

High

782902

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

1

High-throughput

0.479

High

782912

CRY1
Cryptochrome-1

1

1

High-throughput

0.479

High

782915

TECT1
Tectonic-1

1

1

High-throughput

0.479

High

782917

CRY2
Cryptochrome-2

1

1

High-throughput

0.479

High

782934

LS14A
Protein LSM14 homolog A

1

1

High-throughput

0.479

High

782962

SYLC
Leucine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.479

High

59130

VWA8
von Willebrand factor A domain-containing protein 8

1

0

High-throughput

0.458

High

133915

DDX3X
ATP-dependent RNA helicase DDX3X

1

0

Small-scale

0.458

High

150895

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

0

High-throughput

0.458

High

173561

NPHP1
Nephrocystin-1

1

0

High-throughput

0.458

High

262742

CISY
Citrate synthase, mitochondrial

1

0

High-throughput

0.458

High

272508

OFD1
Centriole and centriolar satellite protein OFD1

1

0

High-throughput

0.458

High

298241

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

302993

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

326489

SNAI1
Zinc finger protein SNAI1

1

0

High-throughput

0.458

High

354340

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.458

High

373829

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

384423

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

386245

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

440390

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.458

High

625196

CDK2
Cyclin-dependent kinase 2

1

0

High-throughput

0.458

High

637800

PSA3
Proteasome subunit alpha type-3

1

0

Small-scale

0.458

High

718577

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

749181

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

750782

LICH
Lysosomal acid lipase/cholesteryl ester hydrolase

1

0

High-throughput

0.458

High

777487

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

778952

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

782866

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

782867

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

782870

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

782874

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

0

High-throughput

0.458

High

782883

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

0

High-throughput

0.458

High

782885

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

782888

ELF3
ETS-related transcription factor Elf-3

1

0

High-throughput

0.458

High

782890

RHOG
Rho-related GTP-binding protein RhoG

1

0

High-throughput

0.458

High

782891

VIGLN
Vigilin

1

0

High-throughput

0.458

High

782892

KIF23
Kinesin-like protein KIF23

1

0

High-throughput

0.458

High

782894

MPPA
Mitochondrial-processing peptidase subunit alpha

1

0

High-throughput

0.458

High

782895

MERTK
Tyrosine-protein kinase Mer

1

0

High-throughput

0.458

High

782897

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.458

High

782898

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

782900

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.458

High

782904

CUL7
Cullin-7

1

0

High-throughput

0.458

High

782905

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.458

High

782906

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

782913

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.458

High

782914

NDUA9
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

1

0

High-throughput

0.458

High

782919

SYAM
Alanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

782921

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.458

High

782922

FTM
Protein fantom

1

0

High-throughput

0.458

High

782923

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

782924

ANO7
Anoctamin-7

1

0

Small-scale

0.458

High

782926

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

782929

TAXB1
Tax1-binding protein 1

1

0

High-throughput

0.458

High

782930

DCP2
m7GpppN-mRNA hydrolase

1

0

High-throughput

0.458

High

782931

SPICE
Spindle and centriole-associated protein 1

1

0

High-throughput

0.458

High

782932

PLD6
Mitochondrial cardiolipin hydrolase

1

0

High-throughput

0.458

High

782933

POC5
Centrosomal protein POC5

1

0

High-throughput

0.458

High

782935

FBF1
Fas-binding factor 1

1

0

High-throughput

0.458

High

782937

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

782940

FAKD4
FAST kinase domain-containing protein 4

1

0

High-throughput

0.458

High

782941

MCUR1
Mitochondrial calcium uniporter regulator 1

1

0

High-throughput

0.458

High

782942

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.458

High

782943

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.458

High

782945

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

782948

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

0

High-throughput

0.458

High

782951

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

0

High-throughput

0.458

High

782952

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

0

High-throughput

0.458

High

782953

MTG2
Mitochondrial ribosome-associated GTPase 2

1

0

High-throughput

0.458

High

782954

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

782956

ANLN
Anillin

1

0

High-throughput

0.458

High

782957

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

782958

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

782959

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

782960

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

782961

CHD7
Chromodomain-helicase-DNA-binding protein 7

1

0

High-throughput

0.458

High

782965

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

782966

BAG5
BAG family molecular chaperone regulator 5

1

0

High-throughput

0.458

High

782970

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

0

High-throughput

0.458

High

782972

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.458

High

782973

TRAF6
TNF receptor-associated factor 6

1

0

High-throughput

0.458

High

782920

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.445

High

782955

CELR2
Cadherin EGF LAG seven-pass G-type receptor 2

1

0

High-throughput

0.438

High

782925

TECT3
Tectonic-3

1

1

High-throughput

0.437

High

349167

RASH
GTPase HRas

1

0

High-throughput

0.426

High

377972

PRIO
Major prion protein

1

0

High-throughput

0.426

High

496490

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

782881

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

0

High-throughput

0.426

High

782887

YBOX1
Y-box-binding protein 1

1

0

High-throughput

0.426

High

782944

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.426

High

782975

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

0

High-throughput

0.426

High

401573

JUN
Transcription factor Jun

1

1

High-throughput

0.407

High

782875

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.373

High

782916

DB136
Defensin beta 136

1

0

High-throughput

0.279

Low

782936

SOCS4
Suppressor of cytokine signaling 4

1

0

High-throughput

0.268

Low

782950

Q9BR81
Protocadherin gamma subfamily C, 3

1

0

High-throughput

0.268

Low

100560

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

329458

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

552132

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

650564

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

719868

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

782872

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

782884

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.249

Low

782903

RBM39
RNA-binding protein 39

1

0

High-throughput

0.249

Low

782918

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.249

Low

782927

ASXL2
Putative Polycomb group protein ASXL2

1

0

High-throughput

0.249

Low

782928

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.249

Low

782969

TRI33
E3 ubiquitin-protein ligase TRIM33

1

0

High-throughput

0.249

Low

782971

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024